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Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Primary Purpose

Obesity, Abdominal

Status
Terminated
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Resistance Training
Aerobic Training
Sponsored by
Southern Illinois University Edwardsville
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Obesity, Abdominal focused on measuring Abdominal Fat, Visceral Adipose Tissue, Subcutaneous Adipose Tissue, Exercise, Intervention

Eligibility Criteria

18 Years - 35 Years (Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • 30 - 39.9 kg/m2 BMI
  • White/Caucasian
  • Female
  • Sedentary

Exclusion Criteria:

  • Known cardiovascular, pulmonary, metabolic disease
  • Pregnant females
  • Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
  • Diabetic
  • Hypertension
  • Cigarette smoking
  • MRI related contraindications (metal, no removable devices, etc.)

Sites / Locations

  • Southern Illinois University of Edwardsville

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

No Intervention

Arm Label

Resistance Training Group

Aerobic Training Group

Control Group

Arm Description

Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.

Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.

The control group must attend sessions but will not exercise.

Outcomes

Primary Outcome Measures

Changes in Visceral Abdominal Tissue (VAT)
Changes in VAT will be measured using Magnetic Resonance Imaging

Secondary Outcome Measures

Changes in Subcutaneous Abdominal Tissue (SAT)
Changes in SAT will be measured using Magnetic Resonance Imaging
Changes in Muscular Strength
Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press
Changes in Cardiorespiratory Function
Changes in cardiorespiratory will measured on a treadmill with a metabolic cart
Changes in fat mass (kg)
Changes in fat mass will be measured using dual-energy x-ray absorptiometry
Changes in relative body fat (%BF)
Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry
Changes in relative lean body mass (kg)
Changes in lean body mass will be measured using dual-energy x-ray absorptiometry
Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)
Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis
Changes in concentration of Troponin
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of Fibrinogen
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of C-reactive protein (CRP)
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of IL-6
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of IL-10
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of TNF-alpha
Will be performed using a Luminex MAGPIX System with xPONENT 4.2

Full Information

First Posted
September 5, 2018
Last Updated
September 27, 2021
Sponsor
Southern Illinois University Edwardsville
Collaborators
Washington University School of Medicine
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1. Study Identification

Unique Protocol Identification Number
NCT03700827
Brief Title
Effects of Aerobic and Resistance Training on Abdominal Fat Loss
Official Title
Effects of Aerobic and Resistance Training on Abdominal Fat Loss
Study Type
Interventional

2. Study Status

Record Verification Date
March 2021
Overall Recruitment Status
Terminated
Why Stopped
COVID-19
Study Start Date
October 1, 2017 (Actual)
Primary Completion Date
April 1, 2020 (Actual)
Study Completion Date
May 1, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Southern Illinois University Edwardsville
Collaborators
Washington University School of Medicine

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Obesity, Abdominal
Keywords
Abdominal Fat, Visceral Adipose Tissue, Subcutaneous Adipose Tissue, Exercise, Intervention

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
18 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Resistance Training Group
Arm Type
Experimental
Arm Description
Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.
Arm Title
Aerobic Training Group
Arm Type
Experimental
Arm Description
Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.
Arm Title
Control Group
Arm Type
No Intervention
Arm Description
The control group must attend sessions but will not exercise.
Intervention Type
Other
Intervention Name(s)
Resistance Training
Intervention Description
High-intensity Resistance Training Group
Intervention Type
Other
Intervention Name(s)
Aerobic Training
Intervention Description
Aerobic Interval Training Group
Primary Outcome Measure Information:
Title
Changes in Visceral Abdominal Tissue (VAT)
Description
Changes in VAT will be measured using Magnetic Resonance Imaging
Time Frame
2 assessment periods: at baseline and week 4
Secondary Outcome Measure Information:
Title
Changes in Subcutaneous Abdominal Tissue (SAT)
Description
Changes in SAT will be measured using Magnetic Resonance Imaging
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in Muscular Strength
Description
Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in Cardiorespiratory Function
Description
Changes in cardiorespiratory will measured on a treadmill with a metabolic cart
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in fat mass (kg)
Description
Changes in fat mass will be measured using dual-energy x-ray absorptiometry
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in relative body fat (%BF)
Description
Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in relative lean body mass (kg)
Description
Changes in lean body mass will be measured using dual-energy x-ray absorptiometry
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)
Description
Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of Troponin
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of Fibrinogen
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of C-reactive protein (CRP)
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of IL-6
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of IL-10
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4
Title
Changes in concentration of TNF-alpha
Description
Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Time Frame
2 assessment periods: at baseline and week 4

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: 30 - 39.9 kg/m2 BMI White/Caucasian Female Sedentary Exclusion Criteria: Known cardiovascular, pulmonary, metabolic disease Pregnant females Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos) Diabetic Hypertension Cigarette smoking MRI related contraindications (metal, no removable devices, etc.)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Maria Fernandez del Valle, PhD
Organizational Affiliation
Southern Illinois University of Edwardsville
Official's Role
Principal Investigator
Facility Information:
Facility Name
Southern Illinois University of Edwardsville
City
Edwardsville
State/Province
Illinois
ZIP/Postal Code
62026
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
Undecided

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Effects of Aerobic and Resistance Training on Abdominal Fat Loss

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