Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i) (COFLEX-i)
Chronic Pain, Knee Pain Chronic, Hip Pain Chronic
About this trial
This is an interventional diagnostic trial for Chronic Pain
Eligibility Criteria
Inclusion Criteria:
- Adults between 18 to 70 years old with chronic hip, knee or back pain for >3 months
- Documented moderate to severe chronic pain
- English fluency
- Access to a computer at home and an email account
Exclusion Criteria:
- Lack of email/lack of basic computer skills
- Diagnosed Alzheimer's or documented severe cognitive impairment
- Severely impaired vision or color blindness
- Unable to complete cognitive testing
- An interventional pain procedure within one week prior to enrollment testing
- Scheduled to undergo a pain procedure during the five weeks of cognitive training
- Self-reported claustrophobia
- Contraindication to an MRI scan (i.e. presence of metallic foreign body such as an artificial joint or aneurism clip, implanted pacemaker or spinal cord stimulator)
Sites / Locations
- Washington University in Saint Louis
Arms of the Study
Arm 1
Experimental
Cognitive Training + fMRI
Participants will complete Trail Making Test (TMT) A & B (both electronic and paper-pencil), the paper-pencil Color-Word Matching Stroop Test (CWMST), and its electronic version called "Color Match", and a computer-based subset of NCPT (Neurocognitive Performance Test). In addition, participants will also complete Brief Pain Inventory (BPI), Hospital Anxiety and Depression Scale (HADS), Pain Catastrophizing Scale (PCS), and the Resilience Scale questionnaires at baseline. Participants will be provided with the cognitive training module and participants will be required to complete a targeted 36-minute daily training for 35 days. Participants will be asked to undergo 2 functional magnetic resonance imaging (fMRI) sessions. One prior to, and one after the 5-week cognitive training period.