Multistability: Perception is Inspired by Noise (MUSPIN-B)
Primary Purpose
No Conditions
Status
Recruiting
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
EEG and occulometry
Sponsored by
![University Hospital, Grenoble](https://trials-media.s3.amazonaws.com/orgs/university-hospital-grenoble.jpeg)
About this trial
This is an interventional basic science trial for No Conditions focused on measuring Multistable Perception, Micro eye movement, Electroencephalography
Eligibility Criteria
Inclusion Criteria:
- Signed informed consent
- Medical examination carried out before the participation in the research
- Age between 18 and 55 years
- Minimum level of studies
- Obligation to join the social security system
- normal or corrected vision normal
Exclusion Criteria:
- Subject included in another clinical and / or therapeutic experimentation in progress
- Major vision disorder
- Past or current neurological or neuropsychiatric pathologies
- History of cranial trauma with loss of consciousness.
- Medication treatments likely to modulate brain activity: benzodiazepine, antidepressants, neuroleptics, lithium, etc.
- Diabetes, cardiac pathology, immunodeficiency.
- Medication treatments likely to modulate the activity of the cardiovascular system.
- History of abuse or recent ingestion of alcohol, hard drugs or doping products.
- Consumption of more than 15 cigarettes per day
- Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)
- Major subject subject to a legal protection measure or unable to express their consent (L1121-8 CSP)
- Pregnant, parturient and nursing mothers (L1121-5)
Sites / Locations
- CHU Grenoble-AlpesRecruiting
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
healthy volunteers
Arm Description
Outcomes
Primary Outcome Measures
Micro-eye movement
Eye movements will be recorded with an eye-tracker : the continuous gaze position at each sampling period (1ms)
Electroencephalography
EEG will be recorded with 64 scalp electrodes (sampling rate 1kHz) with alpha and gamma waveform to found synchronuous neural correlates with the peceptive changes.
Secondary Outcome Measures
Full Information
NCT ID
NCT03723044
First Posted
October 22, 2018
Last Updated
January 6, 2023
Sponsor
University Hospital, Grenoble
Collaborators
GIPSA-LAB
1. Study Identification
Unique Protocol Identification Number
NCT03723044
Brief Title
Multistability: Perception is Inspired by Noise
Acronym
MUSPIN-B
Official Title
Multistability: Perception is Inspired by Noise
Study Type
Interventional
2. Study Status
Record Verification Date
January 2023
Overall Recruitment Status
Recruiting
Study Start Date
June 5, 2020 (Actual)
Primary Completion Date
May 2025 (Anticipated)
Study Completion Date
May 2025 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Grenoble
Collaborators
GIPSA-LAB
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Some stimuli, such as sinusoidal networks in motion, or the best known, Necker's cube, are simple visual stimulations generating interpretations of unstable and oscillatory shapes or movements, mutually exclusive. Currently, the explanatory models of these perception phenomena are based on adaptation and learning mechanisms as well as the importance of noise in the perceptual and decision-making system. Often noise is a harmful component, but it can also be a facilitator in perceptual systems: the investigator's eye is always in motion, it is the micro-movements during eye fixation (phase of eye stability). In particular, the role of micro-eye movements has been identified in perceptual systems, and it will be necessary here to relate these micro-movements to the perceptive tilts facing multisable stimuli. However, how to access the perceptive states is a real question, since it has been shown that the participant's transfer of his perceptual state by means of a motor response can alter the very state of the percept. This is why the EEG activity will be analyzed to learn to discriminate the different percepts over time, without disruption of the participant's perceptual exploration endogenous activity.
Detailed Description
Each participant will benefit from a medical interview before inclusion to eliminate the contraindications to this study. The maximum duration of the individual participation of each subject in this study is 5 hours in two sessions. Each session lasts 2h30. Both sessions are spaced a maximum of 14 days apart. Each session includes EEG headset placement and oculometer calibration (20 min), followed by recording EEG and eye tracking activity during a visual cognitive task where the participant will be presented with multi-stable visual stimuli to watch. for one or two minutes after the tests. By repeating the essays and the conditions of presentation, each session will be organized in six blocks of 20 minutes each, interspersed with a break.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
No Conditions
Keywords
Multistable Perception, Micro eye movement, Electroencephalography
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
80 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
healthy volunteers
Arm Type
Experimental
Intervention Type
Other
Intervention Name(s)
EEG and occulometry
Intervention Description
Each participants will spend two sessions of EEG and occulometry during a visual cognitive task where she/her will be presented with multi-stable visual stimuli to gaze at for one or two minutes. Depending on the experimental conditions, the participant will provide or not her/his perceptual state (i.e. which stimulus has been perceived ).
Primary Outcome Measure Information:
Title
Micro-eye movement
Description
Eye movements will be recorded with an eye-tracker : the continuous gaze position at each sampling period (1ms)
Time Frame
along the complete experiment (2 hours) per session and per participant.
Title
Electroencephalography
Description
EEG will be recorded with 64 scalp electrodes (sampling rate 1kHz) with alpha and gamma waveform to found synchronuous neural correlates with the peceptive changes.
Time Frame
along the complete experiment (2 hours) per session and per participant.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Signed informed consent
Medical examination carried out before the participation in the research
Age between 18 and 55 years
Minimum level of studies
Obligation to join the social security system
normal or corrected vision normal
Exclusion Criteria:
Subject included in another clinical and / or therapeutic experimentation in progress
Major vision disorder
Past or current neurological or neuropsychiatric pathologies
History of cranial trauma with loss of consciousness.
Medication treatments likely to modulate brain activity: benzodiazepine, antidepressants, neuroleptics, lithium, etc.
Diabetes, cardiac pathology, immunodeficiency.
Medication treatments likely to modulate the activity of the cardiovascular system.
History of abuse or recent ingestion of alcohol, hard drugs or doping products.
Consumption of more than 15 cigarettes per day
Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)
Major subject subject to a legal protection measure or unable to express their consent (L1121-8 CSP)
Pregnant, parturient and nursing mothers (L1121-5)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Anne Guerin, PhD
Phone
4 76 57 43 73
Ext
0033
Email
anne.guerin@gipsa-lab.grenoble-inp.fr
First Name & Middle Initial & Last Name or Official Title & Degree
Tiphaine Montagnon
Email
tmontagnon@chu-grenoble.fr
Facility Information:
Facility Name
CHU Grenoble-Alpes
City
Grenoble
ZIP/Postal Code
38043
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne GUERIN
First Name & Middle Initial & Last Name & Degree
Laurent VERCUEIL
12. IPD Sharing Statement
Plan to Share IPD
No
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Multistability: Perception is Inspired by Noise
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