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Multistability: Perception is Inspired by Noise (MUSPIN-B)

Primary Purpose

No Conditions

Status

Recruiting

Phase

Not Applicable

Locations

France

Study Type

Interventional

Intervention

EEG and occulometry

About this trial

This is an interventional basic science trial for No Conditions focused on measuring Multistable Perception, Micro eye movement, Electroencephalography

Eligibility Criteria

18 Years - 55 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

Signed informed consent
Medical examination carried out before the participation in the research
Age between 18 and 55 years
Minimum level of studies
Obligation to join the social security system
normal or corrected vision normal

Exclusion Criteria:

Subject included in another clinical and / or therapeutic experimentation in progress
Major vision disorder
Past or current neurological or neuropsychiatric pathologies
History of cranial trauma with loss of consciousness.
Medication treatments likely to modulate brain activity: benzodiazepine, antidepressants, neuroleptics, lithium, etc.
Diabetes, cardiac pathology, immunodeficiency.
Medication treatments likely to modulate the activity of the cardiovascular system.
History of abuse or recent ingestion of alcohol, hard drugs or doping products.
Consumption of more than 15 cigarettes per day
Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)
Major subject subject to a legal protection measure or unable to express their consent (L1121-8 CSP)
Pregnant, parturient and nursing mothers (L1121-5)

Sites / Locations

CHU Grenoble-AlpesRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

healthy volunteers

Arm Description

Outcomes

Primary Outcome Measures

Micro-eye movement

Eye movements will be recorded with an eye-tracker : the continuous gaze position at each sampling period (1ms)

Electroencephalography

EEG will be recorded with 64 scalp electrodes (sampling rate 1kHz) with alpha and gamma waveform to found synchronuous neural correlates with the peceptive changes.

Secondary Outcome Measures

Full Information

NCT ID

NCT03723044

First Posted

October 22, 2018

Last Updated

January 6, 2023

Sponsor

University Hospital, Grenoble

Collaborators

GIPSA-LAB

1. Study Identification

Unique Protocol Identification Number

NCT03723044

Brief Title

Multistability: Perception is Inspired by Noise

Acronym

MUSPIN-B

Official Title

Multistability: Perception is Inspired by Noise

Study Type

Interventional

2. Study Status

Record Verification Date

January 2023

Overall Recruitment Status

Recruiting

Study Start Date

June 5, 2020 (Actual)

Primary Completion Date

May 2025 (Anticipated)

Study Completion Date

May 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

University Hospital, Grenoble

Collaborators

GIPSA-LAB

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

Some stimuli, such as sinusoidal networks in motion, or the best known, Necker's cube, are simple visual stimulations generating interpretations of unstable and oscillatory shapes or movements, mutually exclusive. Currently, the explanatory models of these perception phenomena are based on adaptation and learning mechanisms as well as the importance of noise in the perceptual and decision-making system. Often noise is a harmful component, but it can also be a facilitator in perceptual systems: the investigator's eye is always in motion, it is the micro-movements during eye fixation (phase of eye stability). In particular, the role of micro-eye movements has been identified in perceptual systems, and it will be necessary here to relate these micro-movements to the perceptive tilts facing multisable stimuli. However, how to access the perceptive states is a real question, since it has been shown that the participant's transfer of his perceptual state by means of a motor response can alter the very state of the percept. This is why the EEG activity will be analyzed to learn to discriminate the different percepts over time, without disruption of the participant's perceptual exploration endogenous activity.

Detailed Description

Each participant will benefit from a medical interview before inclusion to eliminate the contraindications to this study. The maximum duration of the individual participation of each subject in this study is 5 hours in two sessions. Each session lasts 2h30. Both sessions are spaced a maximum of 14 days apart. Each session includes EEG headset placement and oculometer calibration (20 min), followed by recording EEG and eye tracking activity during a visual cognitive task where the participant will be presented with multi-stable visual stimuli to watch. for one or two minutes after the tests. By repeating the essays and the conditions of presentation, each session will be organized in six blocks of 20 minutes each, interspersed with a break.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

No Conditions

Keywords

Multistable Perception, Micro eye movement, Electroencephalography

7. Study Design

Primary Purpose

Basic Science

Study Phase

Not Applicable

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

80 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

healthy volunteers

Arm Type

Experimental

Intervention Type

Other

Intervention Name(s)

EEG and occulometry

Intervention Description

Each participants will spend two sessions of EEG and occulometry during a visual cognitive task where she/her will be presented with multi-stable visual stimuli to gaze at for one or two minutes. Depending on the experimental conditions, the participant will provide or not her/his perceptual state (i.e. which stimulus has been perceived ).

Primary Outcome Measure Information:

Title

Micro-eye movement

Description

Eye movements will be recorded with an eye-tracker : the continuous gaze position at each sampling period (1ms)

Time Frame

along the complete experiment (2 hours) per session and per participant.

Title

Electroencephalography

Description

EEG will be recorded with 64 scalp electrodes (sampling rate 1kHz) with alpha and gamma waveform to found synchronuous neural correlates with the peceptive changes.

Time Frame

along the complete experiment (2 hours) per session and per participant.

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

55 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Signed informed consent Medical examination carried out before the participation in the research Age between 18 and 55 years Minimum level of studies Obligation to join the social security system normal or corrected vision normal Exclusion Criteria: Subject included in another clinical and / or therapeutic experimentation in progress Major vision disorder Past or current neurological or neuropsychiatric pathologies History of cranial trauma with loss of consciousness. Medication treatments likely to modulate brain activity: benzodiazepine, antidepressants, neuroleptics, lithium, etc. Diabetes, cardiac pathology, immunodeficiency. Medication treatments likely to modulate the activity of the cardiovascular system. History of abuse or recent ingestion of alcohol, hard drugs or doping products. Consumption of more than 15 cigarettes per day Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP) Major subject subject to a legal protection measure or unable to express their consent (L1121-8 CSP) Pregnant, parturient and nursing mothers (L1121-5)

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Anne Guerin, PhD

Phone

4 76 57 43 73

Ext

0033

anne.guerin@gipsa-lab.grenoble-inp.fr

First Name & Middle Initial & Last Name or Official Title & Degree

Tiphaine Montagnon

tmontagnon@chu-grenoble.fr

Facility Information:

Facility Name

CHU Grenoble-Alpes

City

Grenoble

ZIP/Postal Code

38043

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Anne GUERIN

First Name & Middle Initial & Last Name & Degree

Laurent VERCUEIL

12. IPD Sharing Statement

Plan to Share IPD

Learn more about this trial

Multistability: Perception is Inspired by Noise

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