A Study to Evaluate the Safety and Effectiveness of ILIxadencel Administered Into Tumors in Combination With Checkpoint Inhibitor (CPI) in Patients With ADvanced Cancer (ILIAD)
Carcinoma, Squamous Cell of Head and Neck, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
About this trial
This is an interventional treatment trial for Carcinoma, Squamous Cell of Head and Neck focused on measuring immunotherapy, ilixadencel, checkpoint inhibitor, allogeneic, somatic cell therapy, dendritic cell, intratumoral, in situ
Eligibility Criteria
Inclusion Criteria:
- Must provide written informed consent.
- Must have histologically confirmed and specific (Human Papilloma Virus) HPV-positive or HPV-negative squamous cell carcinoma of the head and neck (SCCHN), non-small-cell lung cancer (NSCLC) or gastric or gastroesophageal junction (GEJ) adenocarcinoma. Patients with other tumor types who are candidates for pembrolizumab therapy (according to the FDA-approved prescribing information at the time of inclusion) can also be enrolled in Phase 1b. Tumor histology and most recent pathology report must be in subject's medical record. Tumor samples and/or biopsies will not be collected as part of this study.
- Eligible for pembrolizumab treatment per country-specific label and per physician's decision.
- ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1.
- Adequate organ function.
- Women of childbearing potential must follow contraceptive requirements; must have a negative pregnancy blood test at screening, and a negative blood or urine pregnancy test within 24 hours before each dose of ilixadencel; and must not be breastfeeding.
- Male subjects must agree to use condoms from screening until 90 days after the last dose of ilixadencel, or must have a female partner using a highly effective method of contraception as described above.
Exclusion Criteria:
- Prior history of invasive malignancy, unless complete remission has been achieved for at least 3 years and no additional therapy is required except for hormonal therapy or bisphosphonates.
- Active or previously untreated brain and/or leptomeningeal metastasis.
- Active autoimmune disease, pneumonitis or interstitial lung disease.
- Certain heart conditions including, but not limited to: Congestive heart failure; uncontrolled hypertension; unstable angina pectoris; pericarditis; myocarditis; mycardial infarction 6 months prior to study.
- Systemic immunosuppression except for replacement therapy.
- Life expectancy of less than 3 months.
- Any prior treatment with ilixadencel or prior treatment with anticancer agents (except pembrolizumab or other CPI for subjects in Phase 1b) within 4 weeks of starting study medication.
- Major surgery or significant traumatic injury within 4 weeks before study start.
- Known infection with human immunodeficiency virus (HIV).
- Active tuberculosis; active infection requiring anti-infective therapy (hepatitis with a negative viral load on maintenance will not be excluded).
Other protocol-defined inclusion/exclusion criteria could apply.
Sites / Locations
- Site 1010
- Site 1006
- Site 1011
- Site 1004
- Site 1009
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Active Comparator
Phase 1b: Cohort 1, ilixadencel + pembrolizumab
Phase 1b: Cohort 2, ilixadencel + pembrolizumab
Phase 1b: Cohort 3, ilixadencel + pembrolizumab
Phase 1b: Cohort 4, ilixadencel + pembrolizumab
Phase 2 exp. cohorts HNSCC/NSCLC/Gastric/GEJ
Phase 2 comparator cohorts HNSCC/NSCLC/Gastric/GEJ
3 x 10⁶ DCs (Dendritic Cells) of ilixadencel, 2x over 4 weeks (w). Pembrolizumab I.V. q3w
10 x 10⁶ DCs of ilixadencel, 2x over 4 weeks. Pembrolizumab I.V. q3w
10 x 10⁶ DCs of ilixadencel, 3x over 10 weeks. Pembrolizumab I.V. q3w
Ilixadencel 3 times over 10 weeks: 1st dose 20 x 10⁶ DCs ilixadencel; 2nd dose 10 x 10⁶ DCs; 3rd dose 10 x 10⁶ DCs. Pembrolizumab I.V. q3w
Subjects with HNSCC, NSCLC, gastric or gastroesophageal junction (GEJ) adenocarcinoma. ilixadencel administered intra-tumorally up to 3 times over 10 weeks; dose determined after Phase 1b. Pembrolizumab I.V. q3w according to currently approved doses and indications.
Subjects with HNSCC, NSCLC, gastric/GEJ adenocarcinoma receiving active treatment with pembrolizumab I.V. q3w according to currently approved doses and indications.