Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology
Opioid-use Disorder
About this trial
This is an interventional treatment trial for Opioid-use Disorder focused on measuring opioid use disorder, Buprenorphine/naloxone, Buprenorphine
Eligibility Criteria
Inclusion Criteria:
- 18 years of age and older
- With a confirmed viable intrauterine pregnancy
- Opioid Use Disorder
- Care in a Stony Brook Medicine OBGYN clinical office sites
- Medication-assisted treatment through Stony Brook Medicine OBGYN office sites
Exclusion Criteria:
- Known or suspected allergy to buprenorphine or buprenorphine/naloxone
- Carrying a fetus with known aneuploidy or anomaly
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
buprenorphine
buprenorphine/naloxone
Buprenorphine 2 mg to 8 mg daily: Light to moderate history of opioid use (heroin, oxycodone, etc.) and/or Clinical Opioid Withdraw Scale (COWS) scores 5-24 Buprenorphine 8 mg to 16 mg daily: Heavy history of opioid use (heroin, oxycodone, etc.) and/or Clinical Opioid Withdraw Scale (COWS) scores 25-36+
Buprenorphine/naloxone 4 mg/1 mg daily once daily or twice daily (BID): Light to moderate history of opioid use (heroin, oxycodone, etc.) and/or Clinical Opioid Withdraw Scale (COWS) scores 5-24 Buprenorphine/naloxone 8 mg/2 mg daily once daily or twice daily (BID): Heavy history of opioid use (heroin, oxycodone, etc.) and/or Clinical Opioid Withdraw Scale (COWS) scores 25-36+