Methylsulfonylmethane on Knee Laxity
Ligament Injury, Ligament; Laxity, Tendon Rupture
About this trial
This is an interventional supportive care trial for Ligament Injury
Eligibility Criteria
Inclusion Criteria:
• Regular menstrual cycle (~1 x month)
- Not using oral contraceptive
- No history of serious knee injury (e.g. ACL rupture)
- Not currently pregnant (known)
- Not routinely taking medication or supplements that would interact with study measures or be contraindicated (e.g. steroid injections)
Exclusion Criteria:
• Irregular menstrual cycling (1 x month)
- Using oral contraceptive
- History of serious knee injury (e.g. ACL rupture)
- Currently pregnant or potential of being pregnant
- Routinely taking medication or supplements that would interact with study measures or be contraindicated (e.g. steroid injections)
Sites / Locations
- Neurobiology, Physiology & Behaviour
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
methylsulfonylmethane
Placebo
Subjects will be given 2 g/day of methylsulfonylmethane (MSM). Salivary estrogen will be measured around ovulation and menstruation each month for 3 months. Knee laxity will be measures 2 times per month at the same time points (ovulation, menstruation).
Subjects will be given 2 g/day placebo (rice flour). Salivary estrogen will be measured around ovulation and menstruation each month for 3 months. Knee laxity will be measures 2 times per month at the same time points as the intervention arm (ovulation, menstruation).