Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
Calcium Oxalate Urolithiasis
About this trial
This is an interventional basic science trial for Calcium Oxalate Urolithiasis focused on measuring Oxalobacter formigenes, oxalate, kidney stones
Eligibility Criteria
Inclusion Criteria:
- Good health as judged from a medical history and reported medications
- Not colonized with O. formigenes
Exclusion Criteria:
- History of any hepatic, renal, bowel or endocrine disease or any other condition that may influence the absorption, transport or urinary excretion of ions, which will compromise the interpretation of results
- colonized with O. formigenes
- abnormal urine chemistries or blood metabolic profiles
Sites / Locations
- University of Alabama at Birmingham
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Low Oxalate Diet
Moderately high oxalate/low calcium diet
Oxalobacter formigenes
Subjects not colonized with Oxalobacter formigenes will be equilibrated to a low oxalate diet to determine baseline oxalate values in urine . Subjects will be colonized with Oxalobacter formigenes (Intervention). Following colonization with Oxalobacter formigenes, urinary oxalate will be measured to determine the impact of colonization.
Subjects not colonized with Oxalobacter formigenes will be equilibrated to a moderately high oxalate/ low calcium oxalate diet to enhance dietary oxalate absorption. Subjects will be colonized with Oxalobacter formigenes(Intervention). Following colonization with Oxalobacter formigenes, urinary oxalate will be measured to determine the impact of colonization.
Subjects will ingest a live preparation of O.formigenes