Does Hyaluronic Acid Affect Periodontal Treatment?
Periodontitis

About this trial
This is an interventional treatment trial for Periodontitis focused on measuring periodontitis, hyaluronic acid, scaling and root planning, adenosione deaminase, catalase, glutathione
Eligibility Criteria
Inclusion Criteria:
- Systemically healthy
- moderate-to-severe periodontitis
- at least five sites with ≥5mm probing depth (PD)
- at least ≥20 teeth
- Stage II-III periodontitis according to the 2017 World Workshop
- Age between18-55
Exclusion Criteria:
- receiving systemic or local antibiotics within the past six months
- prior surgical or non-surgical periodontal treatment within the past six months
- smoking
- pregnancy
- lactation
- age ≤18 years or ≥55 years
- hypertension
- known chronic systemic diseases (i.e., diabetes mellitus, rheumatoid arthritis), - - known hypersensitivity to one of the ingredients of the HA preparation.
Sites / Locations
- Van Yuzuncu Yil University Faculty of Dentistry
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Experimental
Experimental
Experimental
Scaling and root planning (SRP)
Hyaluronic acid gel (HA) and SRP
HA mouthrinse and SRP
HA mouthrinse+gel and SRP
Under local anesthesia, full-mouth SRP was performed within 24 h in a single or two sessions using ultrasonic and hand instruments (Gracey, Hu-Friedy, Chicago, IL, USA) by a single investigator (DA). Immediately after the SRP, HA gel (Gengigel, Hyaluronic acid, gingival gel, Ricefarma S.R.L, Italy) or mouthrinse was performed according to the groups' procedure. In Group 1, the periodontal sulcus was irrigated with saline solution after SRP.
Group 2, after SRP was performed and irrigated with saline the area was dried with a soft air and, then, a gel containing HA was applied intrasulcular.
In Group 3, HA hydrogel mouthrinse (Gengigel, Hyaluronic acid, Hydrogel moutrinse for gums, Ricefarma S.R.L, Italy) were used as an irrigator after SRP.
In Group 4, after SRP was performed, the sulcus was irrigated with HA hydrogel mouthrinse and, then, intrasulculary HA gingival gel was applied.