search
Back to results

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy (COSMIC-312)

Primary Purpose

Hepatocellular Carcinoma

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Cabozantinib
Cabozantinib
Sorafenib
Atezolizumab
Sponsored by
Exelixis
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Hepatocellular Carcinoma focused on measuring liver, cancer, hepatocellular, carcinoma

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Histological or cytological diagnosis of HCC or clinical diagnosis of HCC in cirrhotic patients by CT or MRI per the AASLD 2018 or EASL 2018 guidelines.
  • The subject has disease that is not amenable to a curative treatment approach (eg, transplant, surgery, ablation therapy) or locoregional therapy (eg, TACE).
  • Measurable disease per RECIST 1.1 as determined by the Investigator.
  • Barcelona Clinic Liver Cancer (BCLC) stage Category B or C.
  • Child-Pugh Score of A.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion Criteria:

  • Known fibrolamellar carcinoma, sarcomatoid HCC or mixed hepatocellular cholangiocarcinoma.
  • Prior systemic anticancer therapy for advanced HCC including but not limited to chemotherapy, small molecule kinase inhibitors, and immune checkpoint inhibitors (ICIs). Subjects who have received local intratumoral or arterial chemotherapy are eligible; local anticancer therapy must be completed ≥ 28 days before randomization
  • Radiation therapy for bone metastasis within 2 weeks, any other radiation therapy within 8 weeks prior to randomization.
  • Known brain metastases or cranial epidural disease unless adequately treated with radiotherapy and/or surgery (including radiosurgery) and stable for at least 8 weeks prior to randomization.
  • Concomitant anticoagulation with oral anticoagulants

Sites / Locations

  • Exelixis Clinical Site #208
  • Exelixis Clinical Site #159
  • Exelixis Clinical Site #44
  • Exelixis Clinical Site #112
  • Exelixis Clinical Site #200
  • Exelixis Clinical Site #2
  • Exelixis Clinical Site #207
  • Exelixis Clinical Site #109
  • Exelixis Clinical Site #54
  • Exelixis Clinical Site #58
  • Exelixis Clinical Site #191
  • Exelixis Clinical Site #4
  • Exelixis Clinical Site #195
  • Exelixis Clinical Site #120
  • Exelixis Clinical Site #6
  • Exelixis Clinical Site #7
  • Exelixis Clinical Site #11
  • Exelixis Clinical Site #5
  • Exelixis Clinical Site #8
  • Exelixis Clinical Site #1
  • Exelixis Clinical Site #14
  • Exelixis Clinical Site #76
  • Exelixis Clinical Site #12
  • Exelixis Clinical Site #39
  • Exelixis Clinical Site #176
  • Exelixis Clinical Site #88
  • Exelixis Clinical Site #144
  • Exelixis Clinical Site #199
  • Exelixis Clinical Site #154
  • Exelixis Clinical Site #19
  • Exelixis Clinical Site #13
  • Exelixis Clinical Site #46
  • Exelixis Clinical Site #3
  • Exelixis Clinical Site #217
  • Exelixis Clinical Site #213
  • Exelixis Clinical Site #216
  • Exelixis Clinical Site #219
  • Exelixis Clinical Site #220
  • Exelixis Clinical Site #201
  • Exelixis Clinical Site #78
  • Exelixis Clinical Site #165
  • Exelixis Clinical Site #171
  • Exelixis Clinical Site #126
  • Exelixis Clinical Site #155
  • Exelixis Clinical Site #142
  • Exelixis Clinical Site #17
  • Exelixis Clinical Site #107
  • Exelixis Clinical Site #166
  • Exelixis Clinical Site #72
  • Exelixis Clinical Site #190
  • Exelixis Clinical Site #150
  • Exelixis Clinical Site #137
  • Exelixis Clinical Site #64
  • Exelixis Clinical Site #198
  • Exelixis Clinical Site #174
  • Exelixis Clinical Site #50
  • Exelixis Clinical Site #65
  • Exelixis Clinical Site #169
  • Exelixis Clinical Site #148
  • Exelixis Clinical Site #57
  • Exelixis Clinical Site #188
  • Exelixis Clinical Site #102
  • Exelixis Clinical Site #184
  • Exelixis Clinical Site #89
  • Exelixis Clinical Site #98
  • Exelixis Clinical Site #113
  • Exelixis Clinical Site #203
  • Exelixis Clinical Site #175
  • Exelixis Clinical Site #121
  • Exelixis Clinical Site #186
  • Exelixis Clinical Site #156
  • Exelixis Clinical Site #187
  • Exelixis Clinical Site #181
  • Exelixis Clinical Site #91
  • Exelixis Clinical Site #71
  • Exelixis Clinical Site #205
  • Exelixis Clinical Site #34
  • Exelixis Clinical Site #222
  • Exelixis Clinical Site #194
  • Exelixis Clinical Site #212
  • Exelixis Clinical Site #85
  • Exelixis Clinical Site #233
  • Exelixis Clinical Site #228
  • Exelixis Clinical Site #225
  • Exelixis Clinical Site #242
  • Exelixis Clinical Site #227
  • Exelixis Clinical Site #230
  • Exelixis Clinical Site #231
  • Exelixis Clinical Site #224
  • Exelixis Site #241
  • Exelixis Clinical Site #185
  • Exelixis Clinical Site #221
  • Exelixis Clinical Site #238
  • Exelixis Clinical Site #234
  • Exelixis Clinical Site #246
  • Exelixis Clinical Site #229
  • Exelixis Clinical Site #236
  • Exelixis Clinical Site #226
  • Exelixis Clinical Site #235
  • Exelixis Clinical Site #218
  • Exelixis Clinical Site #223
  • Exelixis Site #239
  • Exelixis Clinical Site #237
  • Exelixis Site #240
  • Exelixis Clinical Site #232
  • Exelixis Clinical Site #130
  • Exelixis Clinical Site #18
  • Exelixis Clinical Site #37
  • Exelixis Clinical Site #10
  • Exelixis Clinical Site #38
  • Exelixis Clinical Site #43
  • Exelixis Clinical Site #27
  • Exelixis Clinical Site #56
  • Exelixis Clinical Site #29
  • Exelixis Clinical Site #48
  • Exelixis Clinical Site #23
  • Exelixis Clinical Site #55
  • Exelixis Clinical Site #16
  • Exelixis Clinical Site #31
  • Exelixis Clinical Site #49
  • Exelixis Clinical Site #47
  • Exelixis Clinical Site #51
  • Exelixis Clinical Site #20
  • Exelixis Clinical Site #32
  • Exelixis Clinical Site #69
  • Exelixis Clinical Site #66
  • Exelixis Clinical Site #68
  • Exelixis Clinical Site #67
  • Exelixis Clinical Site #70
  • Exelixis Clinical Site #244
  • Exelixis Clinical Site #210
  • Exelixis Clinical Site #214
  • Exelixis Clinical Site #215
  • Exelixis Clinical Site #146
  • Exelixis Clinical Site #42
  • Exelixis Clinical Site #9
  • Exelixis Clinical Site #140
  • Exelixis Clinical Site #25
  • Exelixis Clinical Site #26
  • Exelixis Clinical Site #170
  • Exelixis Clinical Site #30
  • Exelixis Clinical Site #33
  • Exelixis Clinical Site #40
  • Exelixis Clinical Site #35
  • Exelixis Clinical Site #163
  • Exelixis Clinical Site #53
  • Exelixis Clinical Site #158
  • Exelixis Clinical Site #152
  • Exelixis Clinical Site #147
  • Exelixis Clinical Site #149
  • Exelixis Clinical Site #131
  • Exelixis Clinical Site #167
  • Exelixis Clinical Site #177
  • Exelixis Clinical Site #182
  • Exelixis Clinical Site #243
  • Exelixis Clinical Site #157
  • Exelixis Clinical Site #127
  • Exelixis Clinical Site #77
  • Exelixis Clinical Site #86
  • Exelixis Clinical Site #114
  • Exelixis Clinical Site #75
  • Exelixis Clinical Site #104
  • Exelixis Clinical Site #105
  • Exelixis Clinical Site #99
  • Exelixis Clinical Site #79
  • Exelixis Clinical Site #93
  • Exelixis Clinical Site #141
  • Exelixis Clinical Site #135
  • Exelixis Clinical Site #132
  • Exelixis Clinical Site #133
  • Exelixis Clinical Site #160
  • Exelixis Clinical Site #134
  • Exelixis Clinical Site #153
  • Exelixis Clinical Site #92
  • Exelixis Clinical Site #52
  • Exelixis Clinical Site #84
  • Exelixis Clinical Site #36
  • Exelixis Clinical Site #60
  • Exelixis Clinical Site #62
  • Exelixis Clinical Site #118
  • Exelixis Clinical Site #117
  • Exelixis Clinical Site #136
  • Exelixis Clinical Site #41
  • Exelixis Clinical Site #24
  • Exelixis Clinical Site #15
  • Exelixis Clinical Site #204
  • Exelixis Clinical Site #211
  • Exelixis Clinical Site #202
  • Exelixis Clinical Site #206
  • Exelixis Clinical Site #209
  • Exelixis Clinical Site #74
  • Exelixis Clinical Site #81
  • Exelixis Clinical Site #95
  • Exelixis Clinical Site #108
  • Exelixis Clinical Site #101
  • Exelixis Clinical Site #80
  • Exelixis Clinical Site #111
  • Exelixis Clinical Site #90
  • Exelixis Clinical Site #73
  • Exelixis Clinical Site #106
  • Exelixis Clinical Site #97
  • Exelixis Clinical Site #116
  • Exelixis Clinical Site #28
  • Exelixis Clinical Site #21
  • Exelixis Clinical Site #22
  • Exelixis Clinical Site #59
  • Exelixis Clinical Site #103
  • Exelixis Clinical Site #164
  • Exelixis Clinical Site #63
  • Exelixis Clinical Site #168
  • Exelixis Clinical Site #45
  • Exelixis Clinical Site #115
  • Exelixis Clinical Site #172
  • Exelixis Clinical Site #110
  • Exelixis Clinical Site #61
  • Exelixis Clinical Site #119
  • Exelixis Clinical Site #162
  • Exelixis Clinical Site #161
  • Exelixis Clinical Site #197
  • Exelixis Clinical Site #145
  • Exelixis Clinical Site #82
  • Exelixis Clinical Site #128
  • Exelixisi Clinical Site #100
  • Exelixis Clinical Site #94
  • Exelixis Clinical Site #96
  • Exelixis Clinical Site #183
  • Exelixis Clinical Site #139
  • Exelixis Clinical Site #143
  • Exelixis Clinical Site #189
  • Exelixis Clinical Site #193
  • Exelixis Clinical Site #178
  • Exelixis Clinical Site #173
  • Exelixis Clinical Site #179
  • Exelixis Clinical Site #180
  • Exelixis Clinical Site #125
  • Exelixis Clinical Site #122
  • Exelixis Clinical Site #123
  • Exelixis Clinical Site #124
  • Exelixis Clinical Site #138
  • Exelixis Clinical Site #83
  • Exelixis Clinical Site #87
  • Exelixis Clinical Site #151
  • Exelixis Clinical Site #129
  • Exelixis Clinical Site #192
  • Exelixis Clinical Site #196

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Other

Arm Label

Experimental arm

Control arm

Single-Agent Cabozantinib arm

Arm Description

Subjects with advanced HCC will receive cabozantinib 40 mg oral, qd + atezolizumab 1200 mg infusion, q3w

Subjects with advanced HCC will receive sorafenib 400 mg bid (twice a day)

Subjects with advanced HCC will receive cabozantinib 60 mg qd

Outcomes

Primary Outcome Measures

Duration of Progression Free Survival (PFS) for the experimental arm vs. the control arm
Duration of PFS per Response Evaluable Criteria in Solid Tumors version 1.1 (RECIST 1.1)
Duration of Overall Survival (OS) for the experimental arm vs. the control arm

Secondary Outcome Measures

Duration of Progression Free Survival (PFS) for the single-agent arm vs. the control arm
Duration of PFS per RECIST 1.1 by BIRC

Full Information

First Posted
November 26, 2018
Last Updated
July 7, 2023
Sponsor
Exelixis
search

1. Study Identification

Unique Protocol Identification Number
NCT03755791
Brief Title
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy
Acronym
COSMIC-312
Official Title
A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy
Study Type
Interventional

2. Study Status

Record Verification Date
June 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
June 10, 2018 (Actual)
Primary Completion Date
March 8, 2021 (Actual)
Study Completion Date
December 1, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Exelixis

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This Phase 3 study evaluates the safety and efficacy of cabozantinib in combination with atezolizumab versus the standard of care sorafenib in adults with advanced hepatocellular carcinoma (HCC) who have not received previous systemic anticancer therapy. A single-agent cabozantinib arm will be enrolled in which subjects receive single agent cabozantinib in order to determine its contribution to the overall safety and efficacy of the combination with atezolizumab.
Detailed Description
This is a multicenter, randomized, open-label, controlled Phase 3 trial of cabozantinib in combination with atezolizumab versus sorafenib in adults with advanced HCC who have not received previous systemic anticancer therapy in the advanced HCC setting. The primary objective of this study is to evaluate the effect of cabozantinib in combination with atezolizumab on the duration of progression-free survival (PFS) and duration of overall survival (OS) versus sorafenib. The secondary objective is to evaluate the activity of single-agent cabozantinib compared with sorafenib in this patient population.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hepatocellular Carcinoma
Keywords
liver, cancer, hepatocellular, carcinoma

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Model Description
Approximately 740 eligible subjects with advanced HCC will be randomized in a 2:1:1 ratio. Experimental arm (approximately 370 subjects) will receive cabozantinib plus atezolizumab. Control arm (approximately 185 subjects) will receive sorafenib. Single-agent cabozantinib arm (approximately 185 subjects) will receive single-agent cabozantinib
Masking
None (Open Label)
Allocation
Randomized
Enrollment
837 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Experimental arm
Arm Type
Experimental
Arm Description
Subjects with advanced HCC will receive cabozantinib 40 mg oral, qd + atezolizumab 1200 mg infusion, q3w
Arm Title
Control arm
Arm Type
Active Comparator
Arm Description
Subjects with advanced HCC will receive sorafenib 400 mg bid (twice a day)
Arm Title
Single-Agent Cabozantinib arm
Arm Type
Other
Arm Description
Subjects with advanced HCC will receive cabozantinib 60 mg qd
Intervention Type
Drug
Intervention Name(s)
Cabozantinib
Other Intervention Name(s)
XL184, Cabometyx®
Intervention Description
Supplied as 20-mg tablets; administered orally daily at 40 mg
Intervention Type
Drug
Intervention Name(s)
Cabozantinib
Other Intervention Name(s)
XL184, Cabometyx®
Intervention Description
Supplied as 60-mg tablets; administered orally once daily at 60 mg
Intervention Type
Drug
Intervention Name(s)
Sorafenib
Other Intervention Name(s)
Nexavar®
Intervention Description
Supplied as 200-mg tablets; administered orally twice daily at 400 mg
Intervention Type
Drug
Intervention Name(s)
Atezolizumab
Other Intervention Name(s)
Tecentriq®
Intervention Description
Supplied as 1200-mg vials; administered as an IV infusion once every 3 weeks (q3w).
Primary Outcome Measure Information:
Title
Duration of Progression Free Survival (PFS) for the experimental arm vs. the control arm
Description
Duration of PFS per Response Evaluable Criteria in Solid Tumors version 1.1 (RECIST 1.1)
Time Frame
Up to 25 months after the first subject is randomized. Defined as time from randomization to the earlier of progressive disease (PD) per RECIST 1.1 as determined by the Blinded Independent Radiology Committee (BIRC) or death from any cause.
Title
Duration of Overall Survival (OS) for the experimental arm vs. the control arm
Time Frame
Up to 38 months after the first subject is randomized. Defined as time from randomization to date of death from any cause.
Secondary Outcome Measure Information:
Title
Duration of Progression Free Survival (PFS) for the single-agent arm vs. the control arm
Description
Duration of PFS per RECIST 1.1 by BIRC
Time Frame
Up to 20 months after the first subject is randomized.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Histological or cytological diagnosis of HCC or clinical diagnosis of HCC in cirrhotic patients by CT or MRI per the AASLD 2018 or EASL 2018 guidelines. The subject has disease that is not amenable to a curative treatment approach (eg, transplant, surgery, ablation therapy) or locoregional therapy (eg, TACE). Measurable disease per RECIST 1.1 as determined by the Investigator. Barcelona Clinic Liver Cancer (BCLC) stage Category B or C. Child-Pugh Score of A. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria: Known fibrolamellar carcinoma, sarcomatoid HCC or mixed hepatocellular cholangiocarcinoma. Prior systemic anticancer therapy for advanced HCC including but not limited to chemotherapy, small molecule kinase inhibitors, and immune checkpoint inhibitors (ICIs). Subjects who have received local intratumoral or arterial chemotherapy are eligible; local anticancer therapy must be completed ≥ 28 days before randomization Radiation therapy for bone metastasis within 2 weeks, any other radiation therapy within 8 weeks prior to randomization. Known brain metastases or cranial epidural disease unless adequately treated with radiotherapy and/or surgery (including radiosurgery) and stable for at least 8 weeks prior to randomization. Concomitant anticoagulation with oral anticoagulants
Facility Information:
Facility Name
Exelixis Clinical Site #208
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85004
Country
United States
Facility Name
Exelixis Clinical Site #159
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85719
Country
United States
Facility Name
Exelixis Clinical Site #44
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Exelixis Clinical Site #112
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Exelixis Clinical Site #200
City
Orange
State/Province
California
ZIP/Postal Code
92868-3201
Country
United States
Facility Name
Exelixis Clinical Site #2
City
Rialto
State/Province
California
ZIP/Postal Code
92377
Country
United States
Facility Name
Exelixis Clinical Site #207
City
San Diego
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
Exelixis Clinical Site #109
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Exelixis Clinical Site #54
City
San Francisco
State/Province
California
ZIP/Postal Code
94158
Country
United States
Facility Name
Exelixis Clinical Site #58
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Facility Name
Exelixis Clinical Site #191
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
Facility Name
Exelixis Clinical Site #4
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30318
Country
United States
Facility Name
Exelixis Clinical Site #195
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Exelixis Clinical Site #120
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Exelixis Clinical Site #6
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Facility Name
Exelixis Clinical Site #7
City
Burlington
State/Province
Massachusetts
ZIP/Postal Code
01805
Country
United States
Facility Name
Exelixis Clinical Site #11
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64128
Country
United States
Facility Name
Exelixis Clinical Site #5
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64131
Country
United States
Facility Name
Exelixis Clinical Site #8
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Exelixis Clinical Site #1
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89169
Country
United States
Facility Name
Exelixis Clinical Site #14
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08903
Country
United States
Facility Name
Exelixis Clinical Site #76
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131
Country
United States
Facility Name
Exelixis Clinical Site #12
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599-7600
Country
United States
Facility Name
Exelixis Clinical Site #39
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43614
Country
United States
Facility Name
Exelixis Clinical Site #176
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Exelixis Clinical Site #88
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Exelixis Clinical Site #144
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Exelixis Clinical Site #199
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Exelixis Clinical Site #154
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Exelixis Clinical Site #19
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Facility Name
Exelixis Clinical Site #13
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
Exelixis Clinical Site #46
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Facility Name
Exelixis Clinical Site #3
City
Spokane
State/Province
Washington
ZIP/Postal Code
99208
Country
United States
Facility Name
Exelixis Clinical Site #217
City
City of Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1118AAT
Country
Argentina
Facility Name
Exelixis Clinical Site #213
City
City of Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1199ABB
Country
Argentina
Facility Name
Exelixis Clinical Site #216
City
City of Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1264AAA
Country
Argentina
Facility Name
Exelixis Clinical Site #219
City
Pilar
State/Province
Buenos Aires
ZIP/Postal Code
B1629ODT
Country
Argentina
Facility Name
Exelixis Clinical Site #220
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Exelixis Clinical Site #201
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000CVB
Country
Argentina
Facility Name
Exelixis Clinical Site #78
City
Camperdown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Facility Name
Exelixis Clinical Site #165
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Exelixis Clinical Site #171
City
Kingswood
State/Province
New South Wales
ZIP/Postal Code
2747
Country
Australia
Facility Name
Exelixis Clinical Site #126
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Facility Name
Exelixis Clinical Site #155
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Exelixis Clinical Site #142
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Facility Name
Exelixis Clinical Site #17
City
Kurralta Park
State/Province
South Australia
Country
Australia
Facility Name
Exelixis Clinical Site #107
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Exelixis Clinical Site #166
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Exelixis Clinical Site #72
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Exelixis Clinical Site #190
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Exelixis Clinical Site #150
City
Klagenfurt
State/Province
Kärnten
ZIP/Postal Code
9020
Country
Austria
Facility Name
Exelixis Clinical Site #137
City
St. Pölten
State/Province
Lower Austria
ZIP/Postal Code
3100
Country
Austria
Facility Name
Exelixis Clinical Site #64
City
Linz
State/Province
Oberosterreich
ZIP/Postal Code
4010
Country
Austria
Facility Name
Exelixis Clinical Site #198
City
Graz
State/Province
Steiermark
ZIP/Postal Code
8036
Country
Austria
Facility Name
Exelixis Clinical Site #174
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Exelixis Clinical Site #50
City
Brussels
State/Province
California
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Exelixis Clinical Site #65
City
Brussels
ZIP/Postal Code
1200
Country
Belgium
Facility Name
Exelixis Clinical Site #169
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Facility Name
Exelixis Clinical Site #148
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Exelixis Clinical Site #57
City
Haine-Saint-Paul
ZIP/Postal Code
7100
Country
Belgium
Facility Name
Exelixis Clinical Site #188
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Exelixis Clinical Site #102
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Exelixis Clinical Site #184
City
Salvador
State/Province
BA
ZIP/Postal Code
40110-060
Country
Brazil
Facility Name
Exelixis Clinical Site #89
City
Belo Horizonte
State/Province
MG
ZIP/Postal Code
30110-022
Country
Brazil
Facility Name
Exelixis Clinical Site #98
City
Belo Horizonte
State/Province
MG
ZIP/Postal Code
30130-090
Country
Brazil
Facility Name
Exelixis Clinical Site #113
City
Curitiba
State/Province
PR
ZIP/Postal Code
81520-060
Country
Brazil
Facility Name
Exelixis Clinical Site #203
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90050-170
Country
Brazil
Facility Name
Exelixis Clinical Site #175
City
Barretos
State/Province
SP
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Exelixis Clinical Site #121
City
Jaú
State/Province
SP
ZIP/Postal Code
17210-120
Country
Brazil
Facility Name
Exelixis Clinical Site #186
City
São Paulo
State/Province
SP
ZIP/Postal Code
01246-900
Country
Brazil
Facility Name
Exelixis Clinical Site #156
City
São Paulo
State/Province
SP
ZIP/Postal Code
01321-001
Country
Brazil
Facility Name
Exelixis Clinical Site #187
City
São Paulo
State/Province
SP
ZIP/Postal Code
01509-010
Country
Brazil
Facility Name
Exelixis Clinical Site #181
City
São Paulo
State/Province
SP
ZIP/Postal Code
04538-132
Country
Brazil
Facility Name
Exelixis Clinical Site #91
City
São Paulo
ZIP/Postal Code
04543-000
Country
Brazil
Facility Name
Exelixis Clinical Site #71
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Exelixis Clinical Site #205
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Facility Name
Exelixis Clinical Site #34
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3E 0V9
Country
Canada
Facility Name
Exelixis Clinical Site #222
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Facility Name
Exelixis Clinical Site #194
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8V 5C2
Country
Canada
Facility Name
Exelixis Clinical Site #212
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
Exelixis Clinical Site #85
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Exelixis Clinical Site #233
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230036
Country
China
Facility Name
Exelixis Clinical Site #228
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350014
Country
China
Facility Name
Exelixis Clinical Site #225
City
Xiamen
State/Province
Fujian
ZIP/Postal Code
361004
Country
China
Facility Name
Exelixis Clinical Site #242
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510280
Country
China
Facility Name
Exelixis Clinical Site #227
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150081
Country
China
Facility Name
Exelixis Clinical Site #230
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450008
Country
China
Facility Name
Exelixis Clinical Site #231
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410008
Country
China
Facility Name
Exelixis Clinical Site #224
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410013
Country
China
Facility Name
Exelixis Site #241
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410013
Country
China
Facility Name
Exelixis Clinical Site #185
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210002
Country
China
Facility Name
Exelixis Clinical Site #221
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
Exelixis Clinical Site #238
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
Exelixis Clinical Site #234
City
Jiangyin
State/Province
Jiansu
ZIP/Postal Code
214400
Country
China
Facility Name
Exelixis Clinical Site #246
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130012
Country
China
Facility Name
Exelixis Clinical Site #229
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
Exelixis Clinical Site #236
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110006
Country
China
Facility Name
Exelixis Clinical Site #226
City
Linyi
State/Province
Shandong
ZIP/Postal Code
276000
Country
China
Facility Name
Exelixis Clinical Site #235
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
Exelixis Clinical Site #218
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310016
Country
China
Facility Name
Exelixis Clinical Site #223
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310022
Country
China
Facility Name
Exelixis Site #239
City
Beijing
ZIP/Postal Code
100034
Country
China
Facility Name
Exelixis Clinical Site #237
City
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
Exelixis Site #240
City
Shanghai
ZIP/Postal Code
200001
Country
China
Facility Name
Exelixis Clinical Site #232
City
Shanghai
ZIP/Postal Code
201305
Country
China
Facility Name
Exelixis Clinical Site #130
City
Montería
State/Province
Cordoba
ZIP/Postal Code
230002
Country
Colombia
Facility Name
Exelixis Clinical Site #18
City
Hradec Králové
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Exelixis Clinical Site #37
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Exelixis Clinical Site #10
City
Praha 4
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Exelixis Clinical Site #38
City
Praha 5
ZIP/Postal Code
150 06
Country
Czechia
Facility Name
Exelixis Clinical Site #43
City
Amiens
ZIP/Postal Code
80054
Country
France
Facility Name
Exelixis Clinical Site #27
City
Besancon
ZIP/Postal Code
25030
Country
France
Facility Name
Exelixis Clinical Site #56
City
Bondy Cedex
ZIP/Postal Code
93140
Country
France
Facility Name
Exelixis Clinical Site #29
City
Caen Cedex 09
ZIP/Postal Code
14033
Country
France
Facility Name
Exelixis Clinical Site #48
City
Clichy
ZIP/Postal Code
92110
Country
France
Facility Name
Exelixis Clinical Site #23
City
Grenoble
ZIP/Postal Code
38043
Country
France
Facility Name
Exelixis Clinical Site #55
City
Lille Cedex
ZIP/Postal Code
59037
Country
France
Facility Name
Exelixis Clinical Site #16
City
Lyon Cedex 4
ZIP/Postal Code
69317
Country
France
Facility Name
Exelixis Clinical Site #31
City
Montbeliard
ZIP/Postal Code
25250
Country
France
Facility Name
Exelixis Clinical Site #49
City
Montpellier
ZIP/Postal Code
34295
Country
France
Facility Name
Exelixis Clinical Site #47
City
Nantes
ZIP/Postal Code
44093
Country
France
Facility Name
Exelixis Clinical Site #51
City
Nice
ZIP/Postal Code
06202
Country
France
Facility Name
Exelixis Clinical Site #20
City
Pessac
ZIP/Postal Code
33604
Country
France
Facility Name
Exelixis Clinical Site #32
City
Vandœuvre-lès-Nancy
ZIP/Postal Code
54511
Country
France
Facility Name
Exelixis Clinical Site #69
City
Batumi
ZIP/Postal Code
6000
Country
Georgia
Facility Name
Exelixis Clinical Site #66
City
Tbilisi
ZIP/Postal Code
0112
Country
Georgia
Facility Name
Exelixis Clinical Site #68
City
Tbilisi
ZIP/Postal Code
0114
Country
Georgia
Facility Name
Exelixis Clinical Site #67
City
Tbilisi
ZIP/Postal Code
0144
Country
Georgia
Facility Name
Exelixis Clinical Site #70
City
Tbilisi
ZIP/Postal Code
0186
Country
Georgia
Facility Name
Exelixis Clinical Site #244
City
Frankfurt
State/Province
Hessen
ZIP/Postal Code
60590
Country
Germany
Facility Name
Exelixis Clinical Site #210
City
Kassel
State/Province
Hessen
ZIP/Postal Code
34125
Country
Germany
Facility Name
Exelixis Clinical Site #214
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
Exelixis Clinical Site #215
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Exelixis Clinical Site #146
City
Hong Kong
Country
Hong Kong
Facility Name
Exelixis Clinical Site #42
City
Hong Kong
Country
Hong Kong
Facility Name
Exelixis Clinical Site #9
City
Hong Kong
Country
Hong Kong
Facility Name
Exelixis Clinical Site #140
City
Budapest
ZIP/Postal Code
1083
Country
Hungary
Facility Name
Exelixis Clinical Site #25
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Exelixis Clinical Site #26
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Exelixis Clinical Site #170
City
Dublin
ZIP/Postal Code
8
Country
Ireland
Facility Name
Exelixis Clinical Site #30
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Facility Name
Exelixis Clinical Site #33
City
Petah Tikva
ZIP/Postal Code
4941492
Country
Israel
Facility Name
Exelixis Clinical Site #40
City
Ramat-Gan
ZIP/Postal Code
5262101
Country
Israel
Facility Name
Exelixis Clinical Site #35
City
Rehovot
ZIP/Postal Code
7661041
Country
Israel
Facility Name
Exelixis Clinical Site #163
City
Tricase
State/Province
Lecce
ZIP/Postal Code
73039
Country
Italy
Facility Name
Exelixis Clinical Site #53
City
Rozzano
State/Province
Milano
ZIP/Postal Code
20089
Country
Italy
Facility Name
Exelixis Clinical Site #158
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Exelixis Clinical Site #152
City
Brescia
ZIP/Postal Code
25124
Country
Italy
Facility Name
Exelixis Clinical Site #147
City
Milan
ZIP/Postal Code
20122
Country
Italy
Facility Name
Exelixis Clinical Site #149
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Exelixis Clinical Site #131
City
Novara
ZIP/Postal Code
28100
Country
Italy
Facility Name
Exelixis Clinical Site #167
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Exelixis Clinical Site #177
City
Torino
ZIP/Postal Code
10126
Country
Italy
Facility Name
Exelixis Clinical Site #182
City
Torino
ZIP/Postal Code
10128
Country
Italy
Facility Name
Exelixis Clinical Site #243
City
Udine
ZIP/Postal Code
33100
Country
Italy
Facility Name
Exelixis Clinical Site #157
City
Goyang-si
State/Province
Gyeonggi-do
ZIP/Postal Code
10408
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #127
City
Suwon
State/Province
Gyeonggi-do
ZIP/Postal Code
16499
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #77
City
Busan
ZIP/Postal Code
47392
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #86
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #114
City
Busan
ZIP/Postal Code
49241
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #75
City
Incheon
ZIP/Postal Code
22332
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #104
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #105
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #99
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #79
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #93
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Exelixis Clinical Site #141
City
Tuxtla Gutiérrez
State/Province
Chiapas
ZIP/Postal Code
29038
Country
Mexico
Facility Name
Exelixis Clinical Site #135
City
León
State/Province
Guanajuato
ZIP/Postal Code
37000
Country
Mexico
Facility Name
Exelixis Clinical Site #132
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64000
Country
Mexico
Facility Name
Exelixis Clinical Site #133
City
Ciudad De México
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Exelixis Clinical Site #160
City
Mexico City
ZIP/Postal Code
06760
Country
Mexico
Facility Name
Exelixis Clinical Site #134
City
San Luis Potosí
ZIP/Postal Code
78250
Country
Mexico
Facility Name
Exelixis Clinical Site #153
City
Veracruz
ZIP/Postal Code
94300
Country
Mexico
Facility Name
Exelixis Clinical Site #92
City
Maastricht
State/Province
Limburg
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Exelixis Clinical Site #52
City
Amsterdam
State/Province
Noord-Holland
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Exelixis Clinical Site #84
City
Rotterdam
State/Province
Zuid-Holland
ZIP/Postal Code
3015 GD
Country
Netherlands
Facility Name
Exelixis Clinical Site #36
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Exelixis Clinical Site #60
City
Grafton
State/Province
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Facility Name
Exelixis Clinical Site #62
City
Newton
State/Province
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Facility Name
Exelixis Clinical Site #118
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
Exelixis Clinical Site #117
City
Pasig City
ZIP/Postal Code
1605
Country
Philippines
Facility Name
Exelixis Clinical Site #136
City
Quezon City
ZIP/Postal Code
1102
Country
Philippines
Facility Name
Exelixis Clinical Site #41
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
02-507
Country
Poland
Facility Name
Exelixis Clinical Site #24
City
Gdansk
State/Province
Pomorskie
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Exelixis Clinical Site #15
City
Mysłowice
State/Province
Slaskie
ZIP/Postal Code
41-400
Country
Poland
Facility Name
Exelixis Clinical Site #204
City
Cluj-Napoca
State/Province
Cluj
ZIP/Postal Code
400015
Country
Romania
Facility Name
Exelixis Clinical Site #211
City
Cluj-Napoca
State/Province
Cluj
ZIP/Postal Code
400015
Country
Romania
Facility Name
Exelixis Clinical Site #202
City
Cluj-Napoca
State/Province
Cluj
ZIP/Postal Code
400641
Country
Romania
Facility Name
Exelixis Clinical Site #206
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Exelixis Clinical Site #209
City
Iaşi
ZIP/Postal Code
700483
Country
Romania
Facility Name
Exelixis Clinical Site #74
City
Kislino
State/Province
Kursk Region
ZIP/Postal Code
305524
Country
Russian Federation
Facility Name
Exelixis Clinical Site #81
City
Kaluga
ZIP/Postal Code
248007
Country
Russian Federation
Facility Name
Exelixis Clinical Site #95
City
Krasnodar
ZIP/Postal Code
350040
Country
Russian Federation
Facility Name
Exelixis Clinical Site #108
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Exelixis Clinical Site #101
City
Murmansk
ZIP/Postal Code
183047
Country
Russian Federation
Facility Name
Exelixis Clinical Site #80
City
Nizhny Novgorod
ZIP/Postal Code
603137
Country
Russian Federation
Facility Name
Exelixis Clinical Site #111
City
Saint Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Exelixis Clinical Site #90
City
Saint-Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Exelixis Clinical Site #73
City
Sochi
ZIP/Postal Code
354057
Country
Russian Federation
Facility Name
Exelixis Clinical Site #106
City
Singapore
ZIP/Postal Code
169610
Country
Singapore
Facility Name
Exelixis Clinical Site #97
City
Singapore
ZIP/Postal Code
217562
Country
Singapore
Facility Name
Exelixis Clinical Site #116
City
Singapore
ZIP/Postal Code
308433
Country
Singapore
Facility Name
Exelixis Clinical Site #28
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Facility Name
Exelixis Clinical Site #21
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Exelixis Clinical Site #22
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Exelixis Clinical Site #59
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Exelixis Clinical Site #103
City
Barcelona
ZIP/Postal Code
08908
Country
Spain
Facility Name
Exelixis Clinical Site #164
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Exelixis Clinical Site #63
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Exelixis Clinical Site #168
City
Valencia
ZIP/Postal Code
46009
Country
Spain
Facility Name
Exelixis Clinical Site #45
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Exelixis Clinical Site #115
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Exelixis Clinical Site #172
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Exelixis Clinical Site #110
City
Saint Gallen
ZIP/Postal Code
9007
Country
Switzerland
Facility Name
Exelixis Clinical Site #61
City
Zurich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
Exelixis Clinical Site #119
City
Changhua
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Exelixis Clinical Site #162
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Exelixis Clinical Site #161
City
Taichung
ZIP/Postal Code
407
Country
Taiwan
Facility Name
Exelixis Clinical Site #197
City
Tainan City
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Exelixis Clinical Site #145
City
Tainan
ZIP/Postal Code
736
Country
Taiwan
Facility Name
Exelixis Clinical Site #82
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Exelixis Clinical Site #128
City
Taipei
ZIP/Postal Code
10491
Country
Taiwan
Facility Name
Exelixisi Clinical Site #100
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Exelixis Clinical Site #94
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Exelixis Clinical Site #96
City
Pathum Wan
State/Province
Bangkok
ZIP/Postal Code
10330
Country
Thailand
Facility Name
Exelixis Clinical Site #183
City
Muang
State/Province
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Exelixis Clinical Site #139
City
Hat Yai
State/Province
Songkla
ZIP/Postal Code
90110
Country
Thailand
Facility Name
Exelixis Clinical Site #143
City
Chiang Mai
ZIP/Postal Code
50200
Country
Thailand
Facility Name
Exelixis Clinical Site #189
City
Istanbul
State/Province
Instanbul
ZIP/Postal Code
34098
Country
Turkey
Facility Name
Exelixis Clinical Site #193
City
Ankara
ZIP/Postal Code
06010
Country
Turkey
Facility Name
Exelixis Clinical Site #178
City
Ankara
ZIP/Postal Code
06230
Country
Turkey
Facility Name
Exelixis Clinical Site #173
City
Edirne
ZIP/Postal Code
22030
Country
Turkey
Facility Name
Exelixis Clinical Site #179
City
Istanbul
ZIP/Postal Code
34214
Country
Turkey
Facility Name
Exelixis Clinical Site #180
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Facility Name
Exelixis Clinical Site #125
City
Chernivtsi
ZIP/Postal Code
58013
Country
Ukraine
Facility Name
Exelixis Clinical Site #122
City
Dnipro
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Exelixis Clinical Site #123
City
Kharkiv
ZIP/Postal Code
61070
Country
Ukraine
Facility Name
Exelixis Clinical Site #124
City
Odesa
ZIP/Postal Code
65055
Country
Ukraine
Facility Name
Exelixis Clinical Site #138
City
Uzhhorod
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
Exelixis Clinical Site #83
City
Bristol
State/Province
England
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
Exelixis Clinical Site #87
City
Cambridge
State/Province
England
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Facility Name
Exelixis Clinical Site #151
City
London
State/Province
England
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Facility Name
Exelixis Clinical Site #129
City
London
State/Province
England
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Facility Name
Exelixis Clinical Site #192
City
Manchester
State/Province
England
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Exelixis Clinical Site #196
City
Belfast
State/Province
Northern Ireland
ZIP/Postal Code
BT9 7AB
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
35798016
Citation
Kelley RK, Rimassa L, Cheng AL, Kaseb A, Qin S, Zhu AX, Chan SL, Melkadze T, Sukeepaisarnjaroen W, Breder V, Verset G, Gane E, Borbath I, Rangel JDG, Ryoo BY, Makharadze T, Merle P, Benzaghou F, Banerjee K, Hazra S, Fawcett J, Yau T. Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2022 Aug;23(8):995-1008. doi: 10.1016/S1470-2045(22)00326-6. Epub 2022 Jul 4.
Results Reference
derived
PubMed Identifier
32491932
Citation
Kelley RK, W Oliver J, Hazra S, Benzaghou F, Yau T, Cheng AL, Rimassa L. Cabozantinib in combination with atezolizumab versus sorafenib in treatment-naive advanced hepatocellular carcinoma: COSMIC-312 Phase III study design. Future Oncol. 2020 Jul;16(21):1525-1536. doi: 10.2217/fon-2020-0283. Epub 2020 Jun 3.
Results Reference
derived

Learn more about this trial

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy

We'll reach out to this number within 24 hrs