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An Examination of Visual Perceptual Training

Primary Purpose

Age-Related Memory Disorders

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Perceptual Cognitive Training (PCT)
Sponsored by
University of Victoria
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Age-Related Memory Disorders focused on measuring memory, visual spatial training, multiple object tracking, Elderly

Eligibility Criteria

60 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Age 60 and over;
  • Have subjective cognitive complaints;
  • The results of the screening test Mini Mental State Examination (MMSE) should be ≥ 24 (this test is used only at baseline visit to verify if the participant might be included in the sample or not).

Exclusion Criteria:

  • Presence of medical diagnosis of a Major Neurocognitive Disorder (e.g. Alzheimer's disease, front temporal lobe dementia, Lewy Body dementia, vascular dementia),
  • Presence of sensory deficits (e.g. colour blindness, monocular/binocular blindness, macular degeneration),
  • Presence of psychiatric disorders (i.e. depression, anxiety),
  • The participants with scores under 24 at MMSE screening test will be excluded and sent to the family doctor (i.e. to minimize the risk of including people with pre-clinical dementia).

Sites / Locations

  • University of Victoria

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Cohort C

Cohort D

Arm Description

Older adults over the age of 60 years old with subjective memory complaints that underwent: the first cognitive assessment (Baseline), intervention is fourteen sessions of Perceptual Cognitive Training (PCT) for seven weeks, a post-treatment cognitive assessment (Week 7), and a follow up cognitive assessment (Week 11)

Older adults over the age of 60 years old with subjective memory complaints that underwent: the first cognitive assessment (baseline), seven weeks of no intervention, a post-treatment cognitive assessment (week 7), and a follow up cognitive assessment (week 11)

Outcomes

Primary Outcome Measures

Change in memory performance in older adults with SMCs
Assessed by CALIFORNIA VERBAL LEARNING TEST

Secondary Outcome Measures

Change in processing speed in older adults with SMCs
Assessed by Delis-Kaplan Executive Function System™ (D-KEFS™).
Change in cognitive flexibility in older adults with SMCs
Assessed by Delis-Kaplan Executive Function System™ (D-KEFS™)
Change in cognitive flexibility in older adults with SMCs
Assessed by Stroop Test
Change in working memory in in older adults with SMCs
Assessed by Digit Span Test

Full Information

First Posted
October 22, 2018
Last Updated
September 27, 2021
Sponsor
University of Victoria
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1. Study Identification

Unique Protocol Identification Number
NCT03763344
Brief Title
An Examination of Visual Perceptual Training
Official Title
An Examination of Visual Perceptual Training in Older Adults With Subjective Memory Complaints
Study Type
Interventional

2. Study Status

Record Verification Date
September 2021
Overall Recruitment Status
Completed
Study Start Date
June 28, 2017 (Actual)
Primary Completion Date
June 30, 2018 (Actual)
Study Completion Date
July 15, 2018 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Victoria

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Perceptual-cognitive training (PCT) is a computerized software game has been shown to improve sport performance in young elite athletes and even to aid in recovery speeds post-concussion. PCT may represent a unique type of training that could ultimately enhance cognitive performance or quality of life in all populations. What is not clear is whether PCT is beneficial to older adults with subjective memory complaints (SMCs). SMCs in older adults are an early risk indicator for Alzheimer's disease, making older adults with SMCs a target population for proactive interventions. The aim of this study was to determine if PCT can serve as a proactive intervention and enhance cognitive abilities in older adults with SMCs. The results of this research protocol introduce a new way of prevention from cognitive decline in healthy older adults and may introduce a new training programs for age-related memory disorder.
Detailed Description
This study was approved by the University of Victoria Human Research Ethics Board (Protocol Number 17-167) and all participants provided their informed written consent prior to participating in this study. In order to reduce the placebo effect, the participants were randomly divided into the experimental and control groups. Participants from both the experimental and control groups received a total of three neuropsychological assessments over a three month period (i.e. baseline, 7 weeks, 11 weeks). Considering that an essential methodological component of the training studies is the use of standardized neuropsychological tests, validated and reliable measures such as STROOP TEST, DIGIT SPAN TEST, TRAIL MAKING TEST, VERBAL FLUENCY TESTS, CALIFORNIA VERBAL LEARNING TEST Second Edition (i.e., standard and alternate forms), were used at different time points. Each assessment was 50-60 minutes in duration and was administered by an expert neuropsychology resident. The first assessment was administered at baseline . Then, the experimental group underwent seven weeks of perceptual cognitive training, while the control group completed seven weeks without formal training. The treatment for the PCT group consisted of 14 sessions of training each lasting 25-30 min, twice per week for seven weeks. After the seven-week time period, a second neuropsychological assessment was performed on both groups. After eleven weeks, a follow-up assessment was conducted to verify whether the benefits of cognitive training endure over time.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Age-Related Memory Disorders
Keywords
memory, visual spatial training, multiple object tracking, Elderly

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Factorial Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
73 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Cohort C
Arm Type
Experimental
Arm Description
Older adults over the age of 60 years old with subjective memory complaints that underwent: the first cognitive assessment (Baseline), intervention is fourteen sessions of Perceptual Cognitive Training (PCT) for seven weeks, a post-treatment cognitive assessment (Week 7), and a follow up cognitive assessment (Week 11)
Arm Title
Cohort D
Arm Type
No Intervention
Arm Description
Older adults over the age of 60 years old with subjective memory complaints that underwent: the first cognitive assessment (baseline), seven weeks of no intervention, a post-treatment cognitive assessment (week 7), and a follow up cognitive assessment (week 11)
Intervention Type
Behavioral
Intervention Name(s)
Perceptual Cognitive Training (PCT)
Intervention Description
Perceptual Cognitive Training (PCT) will be performed by having individuals work with a visual perceptual training software program called NeuroTracker. This device uses Multiple Object Tracking at increasing difficulties to develop high-level brain functions critical to recovery & cognitive health. By increasing in difficulty with each correct response and decreasing in difficulty when mistakes are made, brain function is constantly challenged. Each session (6 mins) delivers a series of mini-tests where the patient needs to remember key targets, then track them moving among distractors for several seconds and then identify them. Simple to do, but always challenging, NeuroTracker adaptively optimizes difficulty to each patient's level, maximizing cognitive stimulation every step of the way.
Primary Outcome Measure Information:
Title
Change in memory performance in older adults with SMCs
Description
Assessed by CALIFORNIA VERBAL LEARNING TEST
Time Frame
First neuropsychological assessment (Baseline). After seven week period both groups underwent the second neuropsychological assessment (Week 7). After eleven weeks a follow-up assessment was conducted (Week 11).
Secondary Outcome Measure Information:
Title
Change in processing speed in older adults with SMCs
Description
Assessed by Delis-Kaplan Executive Function System™ (D-KEFS™).
Time Frame
First neuropsychological assessment (Baseline). After seven week period both groups underwent the second neuropsychological assessment (Week 7). After eleven weeks a follow-up assessment was conducted (Week 11).
Title
Change in cognitive flexibility in older adults with SMCs
Description
Assessed by Delis-Kaplan Executive Function System™ (D-KEFS™)
Time Frame
First neuropsychological assessment (Baseline). After seven week period both groups underwent the second neuropsychological assessment (Week 7). After eleven weeks a follow-up assessment was conducted (Week 11).
Title
Change in cognitive flexibility in older adults with SMCs
Description
Assessed by Stroop Test
Time Frame
First neuropsychological assessment (Baseline). After seven week period both groups underwent the second neuropsychological assessment (Week 7). After eleven weeks a follow-up assessment was conducted (Week 11).
Title
Change in working memory in in older adults with SMCs
Description
Assessed by Digit Span Test
Time Frame
First neuropsychological assessment (Baseline). After seven week period both groups underwent the second neuropsychological assessment (Week 7). After eleven weeks a follow-up assessment was conducted (Week 11).

10. Eligibility

Sex
All
Minimum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Age 60 and over; Have subjective cognitive complaints; The results of the screening test Mini Mental State Examination (MMSE) should be ≥ 24 (this test is used only at baseline visit to verify if the participant might be included in the sample or not). Exclusion Criteria: Presence of medical diagnosis of a Major Neurocognitive Disorder (e.g. Alzheimer's disease, front temporal lobe dementia, Lewy Body dementia, vascular dementia), Presence of sensory deficits (e.g. colour blindness, monocular/binocular blindness, macular degeneration), Presence of psychiatric disorders (i.e. depression, anxiety), The participants with scores under 24 at MMSE screening test will be excluded and sent to the family doctor (i.e. to minimize the risk of including people with pre-clinical dementia).
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Brian R. Christie, Ph.D
Organizational Affiliation
University of Victoria
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Victoria
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8P5C2
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
20644719
Citation
Berry AS, Zanto TP, Clapp WC, Hardy JL, Delahunt PB, Mahncke HW, Gazzaley A. The influence of perceptual training on working memory in older adults. PLoS One. 2010 Jul 14;5(7):e11537. doi: 10.1371/journal.pone.0011537.
Results Reference
background
PubMed Identifier
24005416
Citation
Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A. Video game training enhances cognitive control in older adults. Nature. 2013 Sep 5;501(7465):97-101. doi: 10.1038/nature12486.
Results Reference
background
PubMed Identifier
15953754
Citation
Cavanagh P, Alvarez GA. Tracking multiple targets with multifocal attention. Trends Cogn Sci. 2005 Jul;9(7):349-54. doi: 10.1016/j.tics.2005.05.009.
Results Reference
background
PubMed Identifier
25550444
Citation
Parsons B, Magill T, Boucher A, Zhang M, Zogbo K, Berube S, Scheffer O, Beauregard M, Faubert J. Enhancing Cognitive Function Using Perceptual-Cognitive Training. Clin EEG Neurosci. 2016 Jan;47(1):37-47. doi: 10.1177/1550059414563746. Epub 2014 Dec 30.
Results Reference
background
PubMed Identifier
29707864
Citation
Tullo D, Guy J, Faubert J, Bertone A. Training with a three-dimensional multiple object-tracking (3D-MOT) paradigm improves attention in students with a neurodevelopmental condition: a randomized controlled trial. Dev Sci. 2018 Nov;21(6):e12670. doi: 10.1111/desc.12670. Epub 2018 Apr 30.
Results Reference
background
PubMed Identifier
12271747
Citation
Faubert J. Visual perception and aging. Can J Exp Psychol. 2002 Sep;56(3):164-76. doi: 10.1037/h0087394.
Results Reference
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An Examination of Visual Perceptual Training

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