High Intensity Interval Training in Prediabetes
Prediabetic State
About this trial
This is an interventional basic science trial for Prediabetic State
Eligibility Criteria
Inclusion Criteria:
- prediabetic (insulin-insensitive) patients
- either fasting plasma glucose 100- 125 mg/dl or HbA1c 5.7 - 6.4
- < 3kg bodyweight change within the last 6 months
Exclusion Criteria:
- Any contraindications for exercise
- resulting from anamnesis ( e.g. history of angina pectoris, peripheral arterial disease), ECG at rest or during graded exercise test, echocardiogram, echocardiography or lung function test
- chronical joint pain that makes exercise training on bicycle ergometers impossible
- any conditions that make the successful participation in the study unlikely
- islet cell autoantibodies
- Medication: insulin, thiazolidindiones, statins, antidepressants
- Secondary diseases: History of end-stage liver or kidney disease; pronounced neuropathy or retinopathy
- drug or alcohol abuse
Sites / Locations
- MUViennaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
High intensity interval training
Moderate intensity continuous training
3x/week the following 45 min training protocol on bicycle ergometer for 12 weeks: 5 minutes warm-up phase with a power output of 40% of the maximal power output achieved in an incremental exercise test 30 minutes: intensive cycling bouts of 60s interspersed with 60s of recovery intervals. Power output will be 90% (week 1-6) or 95% (week 7-12) of the maximal power output of the exercise test during the intensive cycling bouts. During recovery intervals, subjects will pedal with a power output of 30% (week 1-6) or 35% (week 7-12) of the maximal power output of the exercise test. 10 minutes with 30% of maximal power output.
3x/week the following 45 min training protocol on bicycle ergometer for 12 weeks: 5 minutes warm-up phase with a power output of 40% of the maximal power output achieved in an incremental exercise test 30 minutes: Continuous training with 60% (week 1-6) or 65% (week 7-12) of maximal power output 10 minutes with 30% of maximal power output.