Targeted vs Standard Fortification of Breast Milk
BPD - Bronchopulmonary Dysplasia, NEC - Necrotizing Enterocolitis, Weight Gain
About this trial
This is an interventional treatment trial for BPD - Bronchopulmonary Dysplasia focused on measuring enteral nutrition, fortification, tailored enteral nutrition
Eligibility Criteria
Inclusion Criteria:
Patients eligible for the trial must comply with all of the following at randomization:
- Gestational age at birth ≤ 32 weeks
- Enteral feeding of at least 80ml/kg/day
- Donor or maternal milk based enteral feeding (at least 50%)
- Parenteral/legal guardian consent
Exclusion Criteria:
- >50% formula based enteral feeding
- Small for gestational age (birth weight < 3rd percentile)
- Congenital abnormalities which increase the risk of NEC
- NEC
- Withdrawal of feeding > 7 days
- Sepsis
- Death
Sites / Locations
- Department of Neonatology and Neonatal Intensive Care Warsaw Medical UniversityRecruiting
- Division of Neonatology and Neonatal Intensive Care, 1st Department of Obstetrics and Gynaecology, The Medical University of Warsaw
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
tailored enteral nutrition
standard enteral nutrition
Tailored Human milk fortification procedure Tailored milk fortification will be done twice a day (8 am and 8 pm) for each following 12 hour nursing shift. Standard fortification will be added first. The remainder amount of protein, lipids and carbohydrates required to meet the recommended by ESPGHAN doses will be acheived by adding single ingrediant nutrients.
Standard fortification will be added according to the unit protocol.