Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair
Postoperative Analgesia
About this trial
This is an interventional treatment trial for Postoperative Analgesia
Eligibility Criteria
Inclusion Criteria:
- Age 3-10 years
- ASA I and II
- Undergoing hypospadias repair surgery
Exclusion Criteria:
- Coagulopathy
- Aspirin or any other analgesic ingestion in the preceding week
- Preexisting neurological or spinal disease
- Hepatic, renal disease and malnutrition
- Severe hypovolemia
- Uncontrolled convulsions
- Refusal of the parents
- Local Skin infection at the puncture site
- Allergy to local anesthetics
- Patient previously involved in other studies
Sites / Locations
- Aga Khan University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Intravenous paracetamol with Caudal Ropivacaine
Placebo
Paracetamol is widely accepted and most commonly used as an adjuvant for postoperative analgesia. It also improves the quality of recovery by attenuating the pain associated with the surgical position. Adverse effects associated with the paracetamol are rare <1/10000, which includes malaise, increased level of hepatic transaminases and hypersensitivity reaction. It has been studied in combination with caudal analgesia with bupivacaine through the rectal route 7,8 with variable results. Caudal anaesthesia is effective in alleviating pain below the umbilicus. Also if the caudal block is administered at the beginning of surgery, the effect will start wearing off 2 to 3 hours post surgery. Administration of paracetamol towards end of surgery may help with both these issues. In this study we aim to investigate the effect of adding intravenous paracetamol in combination with caudal analgesia with ropivacaine, hoping that it may improve quality of postoperative analgesia and recovery.
Intravenous Normal Saline with Caudal Ropivacaine