Chronic Cough and Small Fiber Neuropathy (CHROCOS)
Chronic Cough, Type 2 Diabetes
About this trial
This is an interventional other trial for Chronic Cough focused on measuring cough, diabetes, small fiber neuropathy
Eligibility Criteria
Inclusion Criteria:
In diabetic patients with chronic cough:
- Chronic cough defined by cough for more than 8 weeks.
- Normal chest X-ray
- history of type 2 diabetes
- Age of diabetes onset> 40 years
- Affiliated or beneficiary person of social security
- Free, informed and written consent
In diabetic patients without chronic cough
- History of type 2 diabetes
- Age of discovery of diabetes> 40 years
- Affiliated or beneficiary person of social security
- Free, informed and written consent
Exclusion Criteria:
- Presence of physical signs of peripheral neuropathy
- Active smoking or smoking cessation within the last 12 months
- Pregnant or lactating woman
- History of non-type 2 diabetes (type I, secondary diabetes, monogenic ...)
- Cancer within the last 5 years (except cutaneous squamous cell carcinoma)
- History of anti-cancer chemotherapy
- Suspicion of autoimmune pathology
- Active neurological pathology
- Electromyography in favor of large fiber neuropathy
- Chronic pathology that may interfere with the neurophysiological assessment
- Patient who were given anticoagulation drug therapy, anti-cholinergic drugs, beta-blocker and impossibility to withdraw the treatment before neurophysiological tests
In diabetic patients without chronic cough, another non-inclusion criteria is acute or chronic cough
Sites / Locations
- Hôpital LarreyRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Diabetic patients with chronic cough
Diabetic patients without chronic cough
Diabetic patients with chronic cough defined by cough lasting for more than 8 weeks. Cough assessment, neurological tests and cardiovascular tests and skin biopsy.
Diabetic patients without chronic cough defined by cough lasting for more than 8 weeks. Cough assessment, neurological tests and cardiovascular tests and skin biopsy.