Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Vegetative State, Minimally Conscious State, Spasticity, Muscle
About this trial
This is an interventional treatment trial for Vegetative State focused on measuring transcranial direct current stimulation, disorder of consciousness, muscle hypertonia, spasticity, vegetative state, minimally conscious state
Eligibility Criteria
Inclusion Criteria:
- post comatose patients
- patients in minimally conscious state
- patients with stable condition
- patients free of sedative drugs and Na+ or Ca++ blockers (e.g., carbamazepine) or NMDA receptor antagonist (e.g., dextromethorphan)
Exclusion Criteria:
- premorbid neurology antecedent
- patients in coma
- patients < 28 days after the acute brain injury
- patients with a metallic cerebral implant
- cranioplasty
- shunt
Sites / Locations
- University of Liege
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
active tDCS
sham tDCS
Patients will receive tDCS (bilateral fronto-central stimulation) during 20 minutes preceded and followed by a clinical assessment (Modified Ashworth Scale and Coma Recovery Scale-Revised) and neurophysiological assessment (8 channels EEG).
Patients will receive sham tDCS (5 seconds of stimulation) during 20 minutes preceded and followed by a clinical assessment (Modified Ashworth Scale and Coma Recovery Scale-Revised) and neurophysiological assessment (8 channels EEG).