Closed-loop tDCS in Patients in Minimally Conscious State
Minimally Conscious State
About this trial
This is an interventional treatment trial for Minimally Conscious State focused on measuring transcranial direct current stimulation, minimally conscious state, disorders of consciousness, non invasive brain stimulation, neuromodulation
Eligibility Criteria
Inclusion Criteria:
- CNS medication stable for at least a week,
- Stable diagnosis of MCS (no diagnosis change based on 2 CRS-R performed within 1 week).
- Adult (16 years old - 65 years old)
- > 28 days post injury
Exclusion Criteria:
- open craniotomies,
- VPS under the stimulated area (prefrontal cortex),
- pacemaker,
- metallic cerebral implant, according to safety criteria for transcranial electric stimulation,
- severe medical conditions that might influence clinical diagnosis and EEG activity (e.g., severe hepatic insufficiency or renal failure, or sub-continuous or abundant epileptiform discharges on standard EEG recordings).
Sites / Locations
- University Hospital of LiegeRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
Anodal tDCS High Vigilance
Anodal tDCS Low Vigilance
Anodal tDCS Random Vigilance
Patients will undergo continuous 20 channels EEG and receive anodal tDCS (bilateral prefrontal stimulation) at a pre-determined high level of EEG-derived spectral entropy during 20 minutes followed by a clinical assessment (Coma Recovery Scale-Revised)
Patients will undergo continuous 20 channels EEG and receive anodal tDCS (bilateral prefrontal stimulation) at a pre-determined low level of EEG-derived spectral entropy during 20 minutes followed by a clinical assessment (Coma Recovery Scale-Revised)
Patients will undergo continuous 20 channels EEG and receive tDCS (bilateral prefrontal stimulation) at a random level of EEG-derived spectral entropy during 20 minutes followed by a clinical assessment (Coma Recovery Scale-Revised)