Using Preoperative Anxiety Score to Determine the Total Dose of Butorphanol for Sedation
Preoperative Anxiety Score, Total Dose of Butorphanol
About this trial
This is an interventional treatment trial for Preoperative Anxiety Score focused on measuring Butorphanol, preoperative anxiety, sedation, recommend dose
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ
- 18-75 years
- Scheduled for elective low limb orthopaedic procedures under spinal anesthesia
Exclusion Criteria:
- central system disease
- cardiovascular disease
- autonomic nervous system disease
- long term use of analgesic, sedative, and anti-anxiety drugs
- psychosis
- a patient with a language communication disorder not willing to cooperate with the experimenter
Sites / Locations
- shengjing hospital of China medical university
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Placebo Comparator
preoperative anxiety and butorphanol
preoperative anxiety and saline
non-preoperative anxiety and butorphanol
non-preoperative anxiety and saline
preoperative anxiety scores of patients in Group A were >11 and received an intravenous loading dose of 15ug/kg butorphanol 5 min before starting the surgery, then followed by infusion of 7.5ug/kg/h butorphanol and stopped infusion until the Ramsay sedation score reached 4 points
preoperative anxiety scores of patients in Group B were >11 and received an infusion of the same volume of physiological saline
preoperative anxiety scores of patients in Group C were ≤ 11 and received an intravenous loading dose of 15ug/kg butorphanol 5 min before starting the surgery, then followed by infusion of 7.5ug/kg/h butorphanol and stopped infusion until the Ramsay sedation score reached 4 points
preoperative anxiety scores of patients in Group D were ≤11 and received an infusion of the same volume of physiological saline