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Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS). (CILICA-HS)

Primary Purpose

Cardiac Arrest, Cardiopulmonary Resuscitation

Status
Recruiting
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Guidance of the External Chest Compression
Rhythm of a relay 4 minutes
Sponsored by
University Hospital, Caen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Cardiac Arrest focused on measuring No-Flow, Chest Compression Fraction, Out Hospital, External Chest Compression Relay, External Chest Compression Guidance, External Chest Compression Quality, Correct Compression Score

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Major person
  • Victim of a cardiorespiratory arrest
  • Eligible for inclusion procedure in immediate life emergency
  • Affiliated to the social security system

Exclusion Criteria:

  • Minor person.
  • Pregnant woman over 6 months old or breastfeeding.
  • Known incurable disease.
  • Palliative care in progress.
  • Decision not to resuscitate from the patient (anticipated directives) or from the medical team.
  • Traumatic cardiac arrest.
  • Impossibility or contraindication to the use of the External Chest Compression guidance system.

Sites / Locations

  • University Hospital of CaenRecruiting
  • University Hospital of Amiens
  • Hospital of Cherbourg - Louis Pasteur
  • Hospital of Elbeuf Louviers Val de ReuilRecruiting
  • Hospital of Le Havre -
  • University Hospital of Lille
  • Hospital of Lisieux - Robert Bisson
  • University Hospital of Lyon
  • University Hospital of Rouen
  • Hospital of Valenciennes
  • Hospital Eure-Seine EvreuxRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

No Intervention

Experimental

Experimental

Experimental

Arm Label

Unguided 2 minutes (U2)

Unguided 4 minutes (U4)

Guided 2 minutes (G2)

Guided 4 minutes (G4)

Arm Description

The External Chest Compression are performed without guidance of the CPRmeter device (according to the current guidelines). The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 2 minutes according to the current guidelines.

The External Chest Compression are performed without guidance of the CPRmeter device (according to the current guidelines). The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 4 minutes. (Rhythm of a relay 4 minutes)

The External Chest Compression are performed with guidance of the CPRmeter device. (Guidance of the External Chest Compression) The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 2 minutes according to the current guidelines.

The External Chest Compression are performed with guidance of the CPRmeter device. (Guidance of the External Chest Compression) The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 4 minutes. (Rhythm of a relay 4 minutes)

Outcomes

Primary Outcome Measures

Chest Compression Fraction
The Chest Compression Fraction (in percentage) corresponds to the resuscitation time during which a External Chest Compression is performed (Low Flow) related to the patient's management time by the prehospital rescue team.
Correct Compression Score
The correct compression score (in percentage) corresponds to a External Chest Compression for which simultaneously the depth is correct (50 to 60 mm), the frequency is correct (100 to 120 / min) and the relaxation is correct (<2500 g) .

Secondary Outcome Measures

Depth of External Chest Compression
The depth of External Chest Compression (in millimeters) continuously recorded by the guidance system (average and percentage correct).
Frequency of External Chest Compression
The frequency of External Chest Compression (in number of compression per minute) recorded continuously by the guidance system (average and percentage correct)....
Relaxation of External Chest Compression
The relaxation of External Chest Compression corresponds to the residual force (in grams) recorded continuously by the guidance system (average and percentage correct)
Subjective rescuers' fatigue
The subjective fatigue assessed by rescuers who performed External Chest Compression using the Borg scale (average of the Borg Scale values of rescuers)
The delays and durations of care
The delays and durations of care (in minutes and seconds) based on the following events: cardiac arrest time, start time of the External Chest Compression, start time of resuscitation by the prehospital rescue team, end time of resuscitation (ROSC or death of the patient).
No-Flow and Low-Flow times
The times (in minutes and seconds) of No-Flow (time during which no External Chest Compression is performed) and Low-Flow (time during which External Chest Compression is performed, generating a minimum flow rate of organs).
Recuperation of Spontaneous Circulation
The rate of Recuperation of Spontaneous Circulation (percentage).
survival at hospital arrival
The rate of survival at hospital arrival
Neuron Specific Enolase
The serum Neuron Specific Enolase level (ng/mL)
Survival
The survival rate.
Cerebral Performance Category Score
Cerebral Performance Category Score as discribe in Wijdicks EFM et al. Neurology 2006;67:203-10.

Full Information

First Posted
January 24, 2019
Last Updated
March 21, 2022
Sponsor
University Hospital, Caen
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1. Study Identification

Unique Protocol Identification Number
NCT03817892
Brief Title
Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
Acronym
CILICA-HS
Official Title
Assessment of the Impact of Relay Timing and CPRmeter Guidance on the Quality of External Chest Compression: Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
Study Type
Interventional

2. Study Status

Record Verification Date
March 2022
Overall Recruitment Status
Recruiting
Study Start Date
December 1, 2019 (Actual)
Primary Completion Date
November 30, 2024 (Anticipated)
Study Completion Date
January 1, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Caen

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The management of out-of-hospital cardiac arrest is complex and multifactorial. With an incidence between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, the room for improvement remains significant even today and is based on fast and optimal care. Thus French and international recommendations insist on the central element of external chest compression (ECC) and especially its quality (Monsieurs KG and Al. Resuscitation 2015; 95: 1-80). Improving the chest compression fraction (CCF) by limiting time without cardiac massage (No-Flow) is a second major point of the recommendations (Vaillancourt C and Al. Resuscitation 2011; 82: 1501-7). The survival of cardiac arrest victims is closely related on this No-Flow time. The principle of the chain of survival (early warning - ECC - defibrillation - resuscitation) implies that the deterioration of a single link threaten the whole of the care. To meet these qualitative needs, ECC guidance devices have been developed. They make possible to improve the quality of the ECC achieved (Hostler D and Al. BMJ 2011; 342d512). Their use is one of the areas of improvement mentioned in the recommendations. Our team studied in simulation the prolonged effects of guidance on the quality of the ECC during a prolonged resuscitation, with encouraging results (Buléon C and Al. Am J Emerg Med 2016; 34: 1754-60). The investigators propose a study evaluating the efficiency of the guidance of the ECC and the impact of the time of relay on the CCF. The investigators formulate two hypotheses that they wish to test simultaneously using a 2x2 factorial design, in a multicenter randomized trial. The first assumption is that a 4-minute relay rate improves the CCF (by reducing the No-Flow time) compared to the currently recommended 2-minute relay rate. The second hypothesis is that a guiding device improves the quality of the ECC. This study should, over a period of 2 years, include 500 patients with cardiac arrest for whom specialized resuscitation is undertaken. The investigators hope by this study to improve the knowledge on the optimal rhythm of the ECC and to validate "in vivo" the interest for the guidance found on manikin. This study should make it possible to clarify the recommendations with a high level of evidence in this field and thus contribute to improving the prognosis of the victims of an out-of-hospital cardiac arrest.
Detailed Description
The management of out-of-hospital cardiac arrest is complex and multifactorial. With an incidence between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, the room for improvement remains significant even today and is based on fast and optimal care. Thus French and international recommendations insist on the central element of external chest compression (ECC) and especially its quality (Monsieurs KG and Al. Resuscitation 2015; 95: 1-80). Improving the chest compression fraction (CCF) by limiting time without cardiac massage (No-Flow) is a second major point of the recommendations (Vaillancourt C and Al. Resuscitation 2011; 82: 1501-7). The survival of cardiac arrest victims is closely related on this No-Flow time. The principle of the chain of survival (early warning - ECC - defibrillation - resuscitation) implies that the deterioration of a single link threaten the whole of the care. To meet these qualitative needs, ECC guidance devices have been developed. They make possible to improve the quality of the ECC achieved (Hostler D and Al. BMJ 2011; 342d512). Their use is one of the areas of improvement mentioned in the recommendations. Our team studied in simulation the prolonged effects of guidance on the quality of the ECC during a prolonged resuscitation, with encouraging results (Buléon C and Al. Am J Emerg Med 2016; 34: 1754-60). The investigators propose a study evaluating the efficiency of the guidance of the ECC and the impact of the time of relay on the CCF. The investigators formulate two hypotheses that they wish to test simultaneously using a 2x2 factorial design, in a multicenter randomized trial. The first assumption is that a 4-minute relay rate improves the CCF (by reducing the No-Flow time) compared to the currently recommended 2-minute relay rate. The second hypothesis is that a guiding device improves the quality of the ECC. This study should, over a period of 2 years, include 500 patients with cardiac arrest for whom specialized resuscitation is undertaken. The investigators hope by this study to improve the knowledge on the optimal rhythm of the ECC and to validate "in vivo" the interest for the guidance found on manikin. This study should make it possible to clarify the recommendations with a high level of evidence in this field and thus contribute to improving the prognosis of the victims of an out-of-hospital cardiac arrest. Cardiac arrest (CA) remains a challenge for pre-hospital care. With an incidence of between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, there is yet room for improvement in treatment to reduce morbi-mortality of these patients. The quality of cardiopulmonary resuscitation (CPR) is at the heart of the last three five-year recommendations. (1-3) The latest recommendations emphasize the importance for professionals to work at the highest quality of CPR and External Chest Compression (ECC) possible. (3) The ratio of the time during which the ECC is performed (Low-Flow) to the total time of the resuscitation is referred to as the Chest Compression Fraction (CCF). During CPR, it is essential for the patient's survival to minimize ECC disruption times and therefore to increase the CCF, as this is an independent element in CA survival's improvement. (4,5) ECC interruptions are deleterious to at least two titles. First, they are a source of direct stop in cerebral and coronary perfusions potentially altering the neurological prognosis and the probability of Return of Spontaneous Circulation. (6) Secondly, the quality of the cardiac output generated by the ECC at the time of resuming of the ECC after an interruption is less good for more than 30 seconds: time need for that several chest compressions can restore the best flow possible. (6,7) Reducing these interruptions and improving the ECC is therefore a major goal of improving CPR. The guidelines are that CCF must be greater than 60% and some experts estimate that a CCF of 80% is possible. (8,9) The outcome of patients with pre-hospital CA is significantly, positively and independently correlated with the consistency to different CCF targets, ECC frequency, ECC depth, and brief pre-external electric shock pause (<10 seconds). (10) There is evidence that ECC's guidance improves adequacy to guidelines and allows to be closer with the ECC frequency, depth and release objectives. (11) The investigators have proved in simulation that the guidance of the ECC delays the deterioration of the overall quality of the ECC and its components (frequency, depth and relaxation) related to fatigue during a prolonged ECC beyond the 2 ECC relay minutes currently recommended. (12) Strategies to get closer with the guidelines regarding the quality of the ECC associated with an improvement in CCF should add or even enhance their beneficial effects for the management of CA victims. Achieving high quality CPR requires the measurement of quality of CPR (ECC and CCF). (13,14) This idea of a support strategy enhanced by "bundles" of concepts is developing in the literature. Thus Cheskes S et al. Describe a "high quality CPR" such as the association of a CCF greater than 70% and achievement of the objectives of the recommendations for the frequency and depth of the ECC. (15) The place of devices for guiding the quality of the ECC needs to be specified. Indeed, studies of their use in real-life situations are criticized for their methodological qualities and their size. (16) The use of a real-time guidance device is proposed as a possibility in the latest guidelines without being an indispensable element due to the lack of current evidence. (3) Its use or non-use does not imply any obvious loss of chance for patients. Evidence as to its usefulness therefore remains to be sought. For this reason, the investigators wish, through an original, randomized, multi-center study, to provide some answers to the questions about the possibility of an improvement in CCF by the lengthening of the time between two ECC relays and the effect of guidance on the quality of the ECC. The design of the study will also allow to approach a possible combined effect of ECC relays rhythm and guidance. The currently recommended duration of a two-minute ECC cycle between two relays does not have a consistent evidence based and corresponds to a duration for which the ECC effort can be maintained in principle with efficiency. (3) Objective measures have shown that the quality of the ECC can be maintained beyond 2 minutes. Extending the duration of an ECC cycle could reduce the number of ECC interruptions and thus improve the CCF. The investigators therefore formulate two hypotheses that they wish to test simultaneously using a 2x2 factorial design, in a multicenter randomized trial. The first assumption is that a 4-minutes relay rhythm improves the CCF (by reducing the No-Flow time) compared to the currently recommended 2-minutes relay rhythm. The second hypothesis is that a guiding device improves the quality of the ECC. The CPRmeter® (guidance device used in this study) will record data on the ECC and its quality (depth, frequency, relaxation, CPRmeter® use time, No-Flow time and Low-Flow time) as well as ECC guidance for the group which will benefit from it (the other group will have the screen masked by a screen cap). This study should, over a period of 2 years, include 500 major patients presenting a non-traumatic CA for whom a specialized CPR is undertaken. The investigators hope by this study to improve the knowledge on the optimal rhythm of the CEE and to validate "in vivo" the interest for the guidance found on manikin. This study should clarify the guidelines with a high level of evidence in this area and thus contribute to improving the prognosis of victims of out-hospital CA.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cardiac Arrest, Cardiopulmonary Resuscitation
Keywords
No-Flow, Chest Compression Fraction, Out Hospital, External Chest Compression Relay, External Chest Compression Guidance, External Chest Compression Quality, Correct Compression Score

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Factorial Assignment
Model Description
This is a randomized, multicenter, open-label study using a 2x2 factorial design comparing (i) the rhythm of External Chest Compression relays every 4 minutes versus every 2 minutes on the Chest Compression Fraction; (ii) the use of real-time guidance of the External Chest Compression via a feedback device (CPRmeter®) versus no guidance on the quality of the External Chest Compression (correct compression score).
Masking
None (Open Label)
Masking Description
The participants being in cardiac arrest at the time of the performance of the study, they are not aware of the arm of randomization in which they are initialy and they are inform as soon as their clinical status allow it.
Allocation
Randomized
Enrollment
500 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Unguided 2 minutes (U2)
Arm Type
No Intervention
Arm Description
The External Chest Compression are performed without guidance of the CPRmeter device (according to the current guidelines). The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 2 minutes according to the current guidelines.
Arm Title
Unguided 4 minutes (U4)
Arm Type
Experimental
Arm Description
The External Chest Compression are performed without guidance of the CPRmeter device (according to the current guidelines). The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 4 minutes. (Rhythm of a relay 4 minutes)
Arm Title
Guided 2 minutes (G2)
Arm Type
Experimental
Arm Description
The External Chest Compression are performed with guidance of the CPRmeter device. (Guidance of the External Chest Compression) The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 2 minutes according to the current guidelines.
Arm Title
Guided 4 minutes (G4)
Arm Type
Experimental
Arm Description
The External Chest Compression are performed with guidance of the CPRmeter device. (Guidance of the External Chest Compression) The duration or rhythm of a relay during which a rescuer performs External Chest Compression before being relayed by another rescuer is 4 minutes. (Rhythm of a relay 4 minutes)
Intervention Type
Other
Intervention Name(s)
Guidance of the External Chest Compression
Other Intervention Name(s)
CPRmeter's feedback
Intervention Description
The CPRmeter® device is positioned on the patient's chest with a disposable adhesive. In the situation of guidance of the External Chest Compression the rescuers have access in real time on the screen to visual feedback on the quality of the External Chest Compression performed and indications of possible corrections to improve the quality of the External Chest Compression . In the case of non-guidance of the External Chest Compression , a mask is position on the screen in order to hide the feedback information.
Intervention Type
Other
Intervention Name(s)
Rhythm of a relay 4 minutes
Intervention Description
The duration or rhythm of a relay is the time during which a rescuer performs External Chest Compression before being relayed by another rescuer. This time is 2 minutes in non intervention group according to the current guidelines and 4 minutes in experimental group.
Primary Outcome Measure Information:
Title
Chest Compression Fraction
Description
The Chest Compression Fraction (in percentage) corresponds to the resuscitation time during which a External Chest Compression is performed (Low Flow) related to the patient's management time by the prehospital rescue team.
Time Frame
1 day
Title
Correct Compression Score
Description
The correct compression score (in percentage) corresponds to a External Chest Compression for which simultaneously the depth is correct (50 to 60 mm), the frequency is correct (100 to 120 / min) and the relaxation is correct (<2500 g) .
Time Frame
1 day
Secondary Outcome Measure Information:
Title
Depth of External Chest Compression
Description
The depth of External Chest Compression (in millimeters) continuously recorded by the guidance system (average and percentage correct).
Time Frame
1 day
Title
Frequency of External Chest Compression
Description
The frequency of External Chest Compression (in number of compression per minute) recorded continuously by the guidance system (average and percentage correct)....
Time Frame
1 day
Title
Relaxation of External Chest Compression
Description
The relaxation of External Chest Compression corresponds to the residual force (in grams) recorded continuously by the guidance system (average and percentage correct)
Time Frame
1 day
Title
Subjective rescuers' fatigue
Description
The subjective fatigue assessed by rescuers who performed External Chest Compression using the Borg scale (average of the Borg Scale values of rescuers)
Time Frame
1 day
Title
The delays and durations of care
Description
The delays and durations of care (in minutes and seconds) based on the following events: cardiac arrest time, start time of the External Chest Compression, start time of resuscitation by the prehospital rescue team, end time of resuscitation (ROSC or death of the patient).
Time Frame
1 day
Title
No-Flow and Low-Flow times
Description
The times (in minutes and seconds) of No-Flow (time during which no External Chest Compression is performed) and Low-Flow (time during which External Chest Compression is performed, generating a minimum flow rate of organs).
Time Frame
1 day
Title
Recuperation of Spontaneous Circulation
Description
The rate of Recuperation of Spontaneous Circulation (percentage).
Time Frame
1 day
Title
survival at hospital arrival
Description
The rate of survival at hospital arrival
Time Frame
1 day
Title
Neuron Specific Enolase
Description
The serum Neuron Specific Enolase level (ng/mL)
Time Frame
Day 1 and day 3
Title
Survival
Description
The survival rate.
Time Frame
Day 2 and one month.
Title
Cerebral Performance Category Score
Description
Cerebral Performance Category Score as discribe in Wijdicks EFM et al. Neurology 2006;67:203-10.
Time Frame
up to one month.
Other Pre-specified Outcome Measures:
Title
Demographic data
Description
Demographic data of the population (sexe, age, suspect cause of cardiac arrest, etc)
Time Frame
Day 1

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Major person Victim of a cardiorespiratory arrest Eligible for inclusion procedure in immediate life emergency Affiliated to the social security system Exclusion Criteria: Minor person. Pregnant woman over 6 months old or breastfeeding. Known incurable disease. Palliative care in progress. Decision not to resuscitate from the patient (anticipated directives) or from the medical team. Traumatic cardiac arrest. Impossibility or contraindication to the use of the External Chest Compression guidance system.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Clément BULEON, MD
Phone
+33(0)231064736
Email
buleon-c@chu-caen.fr
First Name & Middle Initial & Last Name or Official Title & Degree
Laurent HALBOUT, MD
Phone
+33(0)231063400
Email
halbout-l@chu-caen.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clément BULEON, MD
Organizational Affiliation
University Hospital of Caen
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Pierre-Yves GUEUGNIAUD, MD, PhD
Organizational Affiliation
University Hospital of Lyon
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Eric ROUPIE, MD, PhD
Organizational Affiliation
University Hospital of Caen
Official's Role
Study Chair
Facility Information:
Facility Name
University Hospital of Caen
City
Caen
State/Province
Normandy
ZIP/Postal Code
14033
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clement BULEON, MD
Phone
+(33)231064736
Email
buleon-c@chu-caen.fr
First Name & Middle Initial & Last Name & Degree
Laurent HALBOUT, MD
First Name & Middle Initial & Last Name & Degree
Xavier ARROT, MD
Facility Name
University Hospital of Amiens
City
Amiens
ZIP/Postal Code
80080
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christophe BOYER, MD
Email
boyer.christophe@chu-amiens.fr
Facility Name
Hospital of Cherbourg - Louis Pasteur
City
Cherbourg
ZIP/Postal Code
50100
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catalin MUNTEAN, MD
Email
c.muntean@ch-cotentin.fr
Facility Name
Hospital of Elbeuf Louviers Val de Reuil
City
Elbeuf
ZIP/Postal Code
76503
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emmanuel MOREL-MARECHAL, MD
Email
emmanuel.morelmarechal@chi-elbeuf-louviers.fr
Facility Name
Hospital of Le Havre -
City
Le Havre
ZIP/Postal Code
76290
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xavier BENET, MD
Email
xav.benet@gmail.com
Facility Name
University Hospital of Lille
City
Lille
ZIP/Postal Code
59000
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kevin HUSSON, MD
Email
husson.k@gmail.com
Facility Name
Hospital of Lisieux - Robert Bisson
City
Lisieux
ZIP/Postal Code
14100
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antoine AUBRION, MD
Email
aubrion.antoine@gmail.com
Facility Name
University Hospital of Lyon
City
Lyon
ZIP/Postal Code
69003
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eric CESAREO, MD
Email
eric.cesareo@chu-lyon.fr
Facility Name
University Hospital of Rouen
City
Rouen
ZIP/Postal Code
76000
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Benoit JARDEL, MD
Email
benoit.jardel@chu-rouen.fr
Facility Name
Hospital of Valenciennes
City
Valenciennes
ZIP/Postal Code
59300
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carine VANDERSTRAETEN, MD
Email
vanderstraeten-c@ch-valenciennes.fr
Facility Name
Hospital Eure-Seine Evreux
City
Évreux
ZIP/Postal Code
27015
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Florian ANDRIRAMIRADO, MD
Email
florian.andriamirado@chi-eureseine.fr

12. IPD Sharing Statement

Plan to Share IPD
Undecided
Citations:
PubMed Identifier
16324990
Citation
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Results Reference
background
PubMed Identifier
20956052
Citation
Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert LL, Deakin C, Koster RW, Wyllie J, Bottiger B; ERC Guidelines Writing Group. European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary. Resuscitation. 2010 Oct;81(10):1219-76. doi: 10.1016/j.resuscitation.2010.08.021. No abstract available.
Results Reference
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PubMed Identifier
26477410
Citation
Monsieurs KG, Nolan JP, Bossaert LL, Greif R, Maconochie IK, Nikolaou NI, Perkins GD, Soar J, Truhlar A, Wyllie J, Zideman DA; ERC Guidelines 2015 Writing Group. European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary. Resuscitation. 2015 Oct;95:1-80. doi: 10.1016/j.resuscitation.2015.07.038. Epub 2015 Oct 15. No abstract available.
Results Reference
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PubMed Identifier
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Citation
Christenson J, Andrusiek D, Everson-Stewart S, Kudenchuk P, Hostler D, Powell J, Callaway CW, Bishop D, Vaillancourt C, Davis D, Aufderheide TP, Idris A, Stouffer JA, Stiell I, Berg R; Resuscitation Outcomes Consortium Investigators. Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation. Circulation. 2009 Sep 29;120(13):1241-7. doi: 10.1161/CIRCULATIONAHA.109.852202. Epub 2009 Sep 14.
Results Reference
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PubMed Identifier
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Citation
Wik L, Olsen JA, Persse D, Sterz F, Lozano M Jr, Brouwer MA, Westfall M, Souders CM, Travis DT, Herken UR, Lerner EB. Why do some studies find that CPR fraction is not a predictor of survival? Resuscitation. 2016 Jul;104:59-62. doi: 10.1016/j.resuscitation.2016.04.013. Epub 2016 May 4.
Results Reference
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PubMed Identifier
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Citation
Berg RA, Sanders AB, Kern KB, Hilwig RW, Heidenreich JW, Porter ME, Ewy GA. Adverse hemodynamic effects of interrupting chest compressions for rescue breathing during cardiopulmonary resuscitation for ventricular fibrillation cardiac arrest. Circulation. 2001 Nov 13;104(20):2465-70. doi: 10.1161/hc4501.098926.
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PubMed Identifier
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Citation
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Citation
Kleinman ME, Brennan EE, Goldberger ZD, Swor RA, Terry M, Bobrow BJ, Gazmuri RJ, Travers AH, Rea T. Part 5: Adult Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S414-35. doi: 10.1161/CIR.0000000000000259. No abstract available.
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Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).

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