Effect of Angiotensin-Neprilysin Inhibition (ARNI) on Prognosis of Chronic Heart Failure
Chronic Heart Failure
About this trial
This is an interventional treatment trial for Chronic Heart Failure focused on measuring Shakurba valsartan, Heart failure, ACEI/ARB
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18
- HFrEF, defined as LVEF≤40% and New York Heart Association (NYHA) class ≥ II.
- Plasma NT-proBNP ≥ 600 pg/ml, or NT-proBNP ≥ 400 pg/ml if patients have been hospitalized for heart failure in 12 months.
- If patients have been taking ACEI/ARB at recruitment, a stable dose equivalent to at least 10mg/day of enalapril will be required.
- Volunteer for the study and sign the informed consent.
Exclusion Criteria:
- Symptomatic hypotension, systolic blood pressure < 95 mmHg at baseline.
- eGFR < 30 ml(/min*1.73m2) at baseline.
- Serum potassium > 5.4 mmol/L at baseline.
- Contraindication of ACEI or ARB.
Sites / Locations
- First Affiliated Hospital of Xi'an Jiaotong UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Experimental
Active Comparator
Newly diagnosed HFrEF ARNI
Newly diagnosed HFrEF ACEI/ARB
Prior diagnosed HFrEF ARNI
Prior diagnosed HFrEF ACEI/ARB
Newly diagnosed HFrEF patients will be administered ARNI Entresto according to the clinical condition among the whole study.
Newly diagnosed HFrEF patients will be administered ACEI/ARB according to the clinical condition among the whole study.
Prior diagnosed HFrEF patients will be administered ARNI Entresto according to the clinical condition among the whole study.
Prior diagnosed HFrEF patients will be administered ACEI/ARB according to the clinical condition among the whole study.