Awareness Detection and Communication in Disorders of Consciousness
Disorder of Consciousness, Paralysis, Motor Neuron Disease
About this trial
This is an interventional basic science trial for Disorder of Consciousness
Eligibility Criteria
Study 1 - Initial assessment/screening
Inclusion Criteria:
- Disorder of consciousness or low awareness state diagnosis ranging from unclear diagnosis in low awareness states, vegetative state and minimally conscious diagnosis. Those with locked in syndrome / completed locked in syndrome resulting from injury or disease e.g., motor neuron disease who do not have health problems that would preclude them from participating may be assessed but considered as a separate cohort to those with low awareness states.
- acute, post-acute patients where appropriate
Exclusion Criteria:
- Participants with brain related diseases or illnesses (e.g., progressive neurological condition or uncontrolled epilepsy) or suffer from pain (these may adversely affect the brain data produced) and are deemed to be unsuitable for the trials by clinical teams.
- Current consumption of medications that cause excessive fatigue or adversely affect cognitive functioning
- Where English is not the individual's first language
- Participant with excessive uncontrollable arm or head movement or teeth grinding as EEG signal quality will be degraded significantly.
Study 2 - BCI training
Inclusion Criteria:
- Those identified in study 1 to have a level of awareness based on observed appropriate brain activations and/or those who have known awareness but are target groups for movement independent assistive devices and technologies controlled using a brain-computer interface.
Exclusion Criteria:
- Participants who have shown no active brain responses in study 1 where the difference between baseline
Sites / Locations
- National Rehabilitation Hospital of Ireland
- Castel Froma Neuro CareRecruiting
- Northern Health and Social Care TrustRecruiting
- Barnsley Hospital NHS Foundation TrustRecruiting
- Belfast Health and Social Care TrustRecruiting
- Frenchay Brain Injury Rehabilitation CentreRecruiting
- NHS LothianRecruiting
- Hull University Teaching Hospitals NHS TrustRecruiting
- The Walton Centre NHS Foundation TrustRecruiting
- Western Health and Social Care TrustRecruiting
- The Huntercombe GroupRecruiting
- Royal Hospital for Neuro-DisabilityRecruiting
- Imperial College Healthcare NHS TrustRecruiting
- Oxford University Hospitals NHS Foundation TrustRecruiting
- Southern Health and Social Care TrustRecruiting
- Sheffield Teaching Hospitals NHS Foundation TrustRecruiting
- South Warwickshire NHS Foundation TrustRecruiting
- Inspire Neurocare WorcesterRecruiting
Arms of the Study
Arm 1
Experimental
Motor imagery based Brain computer interfacing
Brief assessment of motor imagery in response to command, auditory feedback training and responding to binary yes-no closed questions through Electroencephalography based Brain-computer interfacing.