Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry Trial (BLENDER)
Cardiac Failure, Critical Illness
About this trial
This is an interventional treatment trial for Cardiac Failure focused on measuring ECMO, V-A ECMO, Oxygen, Hyperoxia
Eligibility Criteria
Inclusion Criteria:
• Patients ≥18 years who are commenced on V-A ECMO for severe cardiac and/or respiratory failure or following refractory cardiac arrest.
Exclusion Criteria:
- Greater than 6 hours have elapsed from the time of initiation of ECMO to randomisation
- Patients who are suspected or confirmed to be pregnant
- Where an indication exists for a specific oxygen target as part of clinical care (e.g. carbon monoxide poisoning)
- Patients who are already enrolled in another oxygen titration study
- Patients not willing to receive blood products (e.g. Jehovah's Witness)
- Where the treating physician deems the study is not in the patient's best interest
Sites / Locations
- Alfred HealthRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Conservative Oxygen Management Strategy
Liberal Oxygen Management Strategy
Patients allocated to the conservative strategy will have the ECMO blender oxygen fraction (FbO2) will be titrated to achieve a post-oxygenator saturations of 92-96% (the FbO2 cannot be reduced to lower than 0.5). Post-oxygenator arterial blood gases (ABG's) will be taken to ensure safety and to allow for adjustments to be made. The ventilator FiO2 will be titrated to patient oxygen saturations (SpO2) of 92-96%.
Patients allocated to the liberal strategy will have the FbO2 set at 1.0 at all times. The ventilator FiO2 will be titrated to achieve a patient oxygen saturations (SpO2) of 97-100% (but not lower than 0.5).