NGF, TrKA,p75NTR in Men With ED and Diabetes With or Without MS (ED)
Erectile Dysfunction
About this trial
This is an interventional basic science trial for Erectile Dysfunction focused on measuring Erectile Dysfunction, NGF, TrKA, p75NTR
Eligibility Criteria
Inclusion Criteria:
- men with DE and metabolic syndrome
Exclusion Criteria:
- men with DE without metabolic syndrome
Sites / Locations
- Elisabetta CostantiniRecruiting
Arms of the Study
Arm 1
Experimental
Men with ED and diabetes
A peripheral blood sample from the cubital vein A collection of peripheral blood from the routinary cubital vein for hormone dosage and metabolic evaluation An introverted cavernous infiltration of Prostaglandin E1 to achieve erection (Aprostadil); A blood sample from both the corpus cavernosum and the cubital vein, once the erection is achieved Baseline interaction of prostaglandin E1 on the concentration of NGF released in the medium and on the expression of its receptors Evaluation of NGF and Cytokine levels Expression analysis of TrKA and p75NTR receptors and intracellular cytokines in PBMCs