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Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy. (SOLSTICE)

Primary Purpose

Metastatic Colorectal Cancer

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Trifluridine/tipiracil hydrochloride (S95005)
Capecitabine
Bevacizumab experimental
Bevacizumab control
Sponsored by
Institut de Recherches Internationales Servier
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Metastatic Colorectal Cancer focused on measuring Metastatic, Cancer, Colorectal, Colorectal Cancer, Colon, Rectum, Metastasis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Has definitive histologically confirmed adenocarcinoma of the colon or rectum (all other histological types are excluded). Primary tumour localisation must be known.
  2. RAS status based on local biological assessment of tumour biopsy must be available. If RAS status is not available at the time of randomisation, tumour biopsy must be available for RAS status determination (based on local biological assessment).
  3. Patient is not a candidate for standard full dose combination chemotherapy with irinotecan or oxaliplatin
  4. Patient is not a candidate for curative resection of metastatic lesions.
  5. No previous systemic anticancer therapy for unresectable metastatic colorectal cancer.
  6. ECOG (Eastern Cooperative Oncology Group) performance status ≤2.

  7. Adequate organ function (renal, haematological, hepatic, coagulation) as described in the study protocol'

    Exclusion Criteria:

  8. Pregnancy, breastfeeding or possibility of becoming pregnant during the study.
  9. Participation in another interventional study within 4 weeks prior to the randomisation .
  10. Patients who have not recovered from clinically relevant non-hematologic CTCAE grade ≥ 3 toxicity of previous anticancer therapy prior to the randomisation.
  11. Symptomatic central nervous system metastases.

  12. Major surgery within 4 weeks prior to the randomisation.

    Exclusion criteria related to S 95005 administration:

  13. History of allergic reactions attributed to compounds of similar composition to S 95005 or any of its excipients.

  14. Any contraindication present in the SmPC of trifluridine/tipiracil

    Exclusion criteria related to bevacizumab administration:

  15. Any contraindication present in the SmPC of bevacizumab

    Exclusion criteria related to capecitabine administration:

  16. Any contraindication present in the SmPC of capecitabine

Sites / Locations

  • Centro de Oncología e Investigación de Buenos Aires COIBA
  • Fundación Favaloro Oncology Unit
  • Instituto Alexander Fleming
  • Hospital Universitario CEMIC Servicio de Oncología, Unidad de tumores gastrointestinales
  • Hospital de Gastroenterología Dr. Carlos Borino Udaondo Oncology Unit
  • Centro Oncológico Riojano Integral CORI Fundación CORI para la Investigación y Prevención del Cáncer
  • Fundación COIR Centro Oncológico de Interación Regional
  • Instituto de Oncología de Rosario
  • ISIS Centro especializado
  • Centro Médico San Roque
  • Blacktown Hospital Cancer and Haematology Centre
  • Frankston Private Peninsula and Southeast Oncology Group
  • Lake Macquarie Private Hospital
  • St George Hospital St George Hospital Cancer Care Centre
  • Adventist HealthCare Integrated Cancer Centre
  • Southern Medical Day Care Centre
  • Med. Universität Graz Klinische Abteilung für Onkologie
  • Medizinische Universität Innsbruck Univ.-Klinik für Innere Medizin V
  • Ordensklinikum Linz Barmherzige Schwestern Interne I
  • Landeskrankenhaus (SALK) Universitätsklinik für Innere Medizin III (SALK)
  • Universitätsklinikum St. Pölten Klinische Abteilung für Innere Medizin I
  • Allgemeines Krankenhaus - Universitätskliniken Klinische Abteilung für Onkologie
  • Hospital do Câncer de Barretos - Fundação Pio XII Unidade de Pesquisa Clínica
  • Cenantron - Clinica
  • Sirio Libanes DF - Centro de Oncologia de Braslia do Sirio- Centro Intergrado de Pesquisa
  • Centro de Pesquisa Hospital de Caridade de Ijuí Unidade de Pesquisa Clínica
  • Hospital Mae de Deus Oncologia
  • Hospital São Rafael Centro Intergrado de Pesquisa
  • CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncol Centro Intergrado de Pesquisa
  • Hospital de Base Centro Integrado de Pesquisa
  • ICESP - Instituto do Câncer do Estado de São Paulo Centro Integrado de Pesquisa
  • Hospital A C Camargo Unidade de Pesquisa Clinica
  • "Complex oncology center - Burgas" EOOD Department of medical oncology
  • "Multiprofile hosp. for active treatmen Dr. Tota Venkova" AD Department of medical oncology
  • "Complex oncology center - Plovdiv" EOOD, IInd base Dpt. of Med. oncology and onc. diseases in gastroenterology
  • "Spec. hospital for active treatment of oncology dis." EOOD Department of medical oncology and palliative care
  • "Medical Center Nadezhda Clinical" EOOD Medical Oncology Department
  • "UMHAT Sv. Ivan Rilski" EAD Clinic of clinical hematology, Dpt. of medical oncology
  • MHAT Serdika EOOD Department of Medical Oncology
  • Spec. hospital for active treatment of oncology dis. EOOD Department of medical oncology and palliative car
  • SHAT of oncology diseases Dr. Marko Antonov Markov" EOOD Department of medical oncology and palliative therapy
  • "Complex Ongology Center - Vratsa" EOOD Department of Medical oncology
  • Masarykuv onkologicky ustav Klinika komplexni onkologicke pece
  • Fakultni nemocnice Ostrava Klinika onkologicka
  • Vseobecna fakultni nemocnice Onkologicka klinika VFN a 1. LF UK
  • Thomayerova nemocnice Onkologicka klinika 1. LF UK a TN
  • Fakultni nemocnice Olomouc Onkologicka klinika
  • Aalborg Universitetshospital, Syd Onkologisk Afdelin
  • Regionshospitalet Herning, Hospitalsenheden Vest Onkologisk Afdeling
  • Rigshospitalet Onkologisk Klinik
  • Odense Universitetshospital Onkologisk Afdeling R
  • East Tallinn Central Hospital Center of Oncology
  • North Estonia Medical Centre Foundation Oncology and Haematology clinic
  • Tartu University Hospital, Hematology - Oncology clinic, Radiotherapy and oncological therapy
  • Institut Sainte Catherine
  • CHU Jean Minjoz Service d'oncologie médicale
  • CHU Morvan Institut de Cancérologie et d'Hématologie
  • Hopital Privé Jean Mermoz Service de Gastro entérologie et d'Oncologie médicale
  • Hôpital Nord Franche-Comté - Site du Mittan Service d'oncologie médicale
  • Centre Antoine Lacassagne Dpt d'Oncologie Médicale
  • Hôpital Saint-Antoine Service d'Oncologie Médicale
  • Hôpital Européen Georges Pompidou Oncologie Hépatogastroenterologie-oncologie digestive
  • Hopital Haut-Leveque Hepato-gastroenterologie et oncologie digestive
  • CHU Toulouse Rangueil Oncologie médicale digestive
  • Onkologische Schwerpunktpraxis Kurfuerstendamm
  • Lübecker Onkologische Schwerpunktpraxis im Hochschulstadttei
  • Klinikum der Universität München Campus Großhadern, Medizinische Klinik und Poliklinik III
  • Magyar Honvedseg Egeszsegugyi Kozpont Onkologiai Osztaly
  • Semmelweis University Radiology and Oncotherapy Clinic
  • Del-Pesti Centrumkh-Orsz. Hematologiai es Infektologiai Int. Szent Laszlo Telephely
  • Szent Imre Egyetem Oktatokorhaz Klinikai Onkologia
  • Orszagos Onkologiai Intezet "B" Belgyogyaszati-Onkologiai O. Es Klin. Farmakologiai O.
  • Uzsoki Utcai Korhaz Onkoradiologiai Osztaly
  • Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum Onkologiai Intezet
  • Bekes Megyei Kozponti Korhaz
  • Petz Aladar Megyei Oktato Korhaz Onkoradiologiai Osztaly
  • Bacs-Kiskun Megyei Korhaz Onkoradiologiai Kozpont
  • Szabolcs-Szatmar-Bereg Megyei Korhazak Onkoradiologiai Osztaly
  • Pecsi Tudomanyegyetem, Klinikai Kozpont Onkoterapias Intezet
  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kp. Onkoterápiás Klinika
  • JNSZ Megyei Hetenyi Geza Korhaz es Rendelointezet Megyei Onkologiai Centrum
  • Markusovsky Egyetemi Oktatokorhaz Onkoradiologiai Osztaly
  • Zala Megyei Korhaz Onkologiai osztaly
  • Bon Secours Hospital
  • Cork University Hospital Department of Medical Oncology
  • The Adelaide and Meath Hospital
  • Azienda Policlinico Universitaria - Presidio Monserrato Oncologia Medica
  • Azienda Socio Sanitaria Territoriale di Cremona ONCOLOGIA
  • Istituto Nazionale Tumori I.R.C.C.S "Fondazione G. Pascale" Struttura Complessa di Oncologia Medica Addominale
  • Istituto Oncologico Veneto IOV - IRCCS Unità Operativa Complessa Oncologia Medica 1
  • A.O.U. Pisana-Ospedale Santa Chiara U.O. di Oncologia Medica 2
  • Ospedale San Carlo U.O. Oncologia Medica
  • Arcispedale Santa Maria Nuova Unità di Oncologia
  • Policlinico Universitario Campus Biomedico UOC di Oncologia Medica
  • Istituto Clinico Humanitas I.R.C.C.S Dipartimento di Oncologia Medica ed Ematologia
  • IRCSS Casa Sollievo della Sofferenza Dipartimento Onco-Ematologia
  • Ospedale S. Bortolo -ULSS8 Berica Distretto Est U.O. ONCOLOGIA
  • P. Stradins Clinical University Hospital
  • Riga East Univerity Hospital Oncology Centre of Latvia
  • Oncology Hospital, Branch of Hospital of Lithuanian Uni. of Health Sciences Kauno klinikos
  • Hospital of Lithuania Univ of Health Sciences Kauno klinikos Oncology Institute
  • Klaipeda University hospital
  • National Cancer Institute
  • Rijnstate Oncologie
  • Albert Schweitzer Ziekenhuis Interne Geneeskunde
  • Catharina Ziekenhuis Interne Gesneeskunde/Oncologie
  • Ikazia Ziekenhuis Oncologie
  • ETZ Elisabeth Interne Geneeskunde
  • Bernhoven Interne Geneeskunde
  • Bialostockie Centrum Onkologii im Marii Curie-Sklodowskiej Oddzial Onkologii Klinicznej im Dr Ewy Pileckiej z pododdzialem Chemioterapii Dziennej
  • Uniwersyteckie Centrum Kliniczne Klinika Onkologii i Radioterapii
  • Przychodnia Lekarska "KOMED"
  • SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii Oddzial Kliniczny Onkologii i Immunoonkologii
  • Opolskie Centrum Onkologii im. Tadeusza Koszarowskiego Oddzial Onkologii Klinicznej
  • Wielkopolskie Centrum Onkologii im Marii Sklodowskiej-Curie Oddzial Chemioterapii
  • NU-MED Centrum Diagnostyki i Terapii Onkologicznej Tomaszów Mazowiecki II Sp. z o.o., Pododdzial Chemioterapi
  • M. Kopernika Provincial Hospital Oddzial Chemioterapii Nowotworow
  • Hospital Garcia de Orta Serviço de Oncologia Médica
  • Centro Hospitalar e Universitário de Coimbra - CHUC Unidade de Inovação e Desenvolvimento (UID)
  • Centro Hospitalar Lisboa Norte, Hospital de Santa Maria Serviço de Oncologia Médica
  • Hospital Beatriz Ângelo Serviço de oncologia medic
  • Instituto Português de Oncologia do Porto FG, EPE -IPO Porto Medical Oncology Dept.
  • Institutul Oncologic "Prof Alexandru Trestioreanu" Busuresti Sectia Oncologie Medicala I
  • Spitalul Clinic "Coltea" Sectia Oncologie Medicala
  • Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj Napoca Oncologie Medicala
  • Centrul de Oncologie Sf Nectarie Oncology Department
  • S.C Oncolab S.R.L Sectia Oncologie Medicala
  • Institutul Regional de Oncologie Iasi Clinica de Oncologie Medicala
  • Spitalul Clinic Judetean de Urgenta Sibiu Sectia Oncologie Medicala
  • S.C ONCOMED S.R.L Departament Oncologie Medicala
  • Arkhangelsk Clinical Oncology Dispensary chemotherapy department
  • Clinical Oncology Dispensary No.1 Chemotherapy Department
  • Kursk Regional Clinical Oncology Dispensary Oncology Department
  • Russian Cancer Research Center n.a. NN Blokhin Clinical Pharmacology and Chemotherapy
  • University Headache Clinic Outpatient oncology clinic
  • Moscow City Oncology Hospital # 62 chemotherapy department
  • Omsk Clinical Oncologic Dispensary Chemotherapy
  • Pyatigorsk Interdistrict Oncology Dispensary Chemotherapy department
  • Rostov Research Institute of Oncology Chemotherapy department
  • Regional Clinical Oncology Dispensary
  • Scientific Centre for Specialized Medical Care (oncological) Chemotherapy
  • National Medical Research Center of Oncology N.N. Petrova
  • Saint Petersburg City Oncology Clilnic
  • Multidisciplinary clinic "Reaviz"
  • Oncology Dispensary No.2
  • State Research Institution of Oncology of Tomsk Chemotherapy
  • SBIH of YR "Clinical oncology hospital" chemotherapy department
  • Narodny onkologicky ustav Oddelenie klinickej onkologie
  • Vychodoslovensky onkologicky ustav Oddelenie klinickej onkologie
  • Hospital General Universitario Alicante Servicio de Oncología
  • Hospital Germans Trias i Pujol Unidad de Investigación clínica (UIC) ICO-Oncología medica
  • H. Valle de Hebrón Servicio de Oncología - (VHIR)
  • Hospital de la Santa Creu I Sant Pau Oncología Medica
  • Hospital Uni. Reina Sofía - Hospital Provincial Departamento de Oncología Médica
  • INSTITUTO CATALAN DE ONCOLOGÍA - ICO Oncología Médica
  • Hospital Unviersitario Gregorio Marañon Servicio de Oncología Médica
  • Hospital Universitario Ramón y Cajal, Servicio de Oncologia Médica
  • H. Clínico San Carlos Servicio de Oncología Médica
  • HOSPITAL 12 DE OCTUBRE Servicio Oncología Médica
  • H. Universitario La Paz Oncología Médica
  • Hospital Universitario Marqués de Valdecilla Oncología médica
  • H.Virgen Del Rocio
  • Hospital Quirónsalud Valencia Servicio de Oncología Médica
  • Hospital Universitario Miguel Servet Servicio de Oncología
  • Falu Lasarett Onkologmottagningen
  • Lanssjukhuset Ryhov Onkologiska kliniken
  • Karolinska University Hospital, Solna Studiebehandlingsenheten, B8:09
  • Norrlands Universitetssjukhus Cancercentrum Umea
  • Universitetssjukhuset Orebro
  • Cherkasy Regional Oncological Dispensary Regional Clinical Oncological Centre
  • Dnipro Regional Oncology Dispensary
  • MI "Dnipropetrovsk City Multi-field Clinical Hospital #4" Department of Oncology
  • Institute of Medical Radiology of S.P. Grygoryev of AMS UKR
  • National Institute of Cancer Abdominal Oncology Department
  • Kyiv City Clinical Oncology Centre Chemotherapy Department #2
  • Municipal Institution of Kyiv Regional Council "Kyiv Regional Clinical Hospital", proctology department
  • Lviv Regional Oncology Center Chemotherapy department
  • Odesa Regional Oncology Dispensary Day patient Department
  • Podillia Regional Oncology Centre Chemotherapy Department
  • Regional Clinical Oncological Dispensary Department of Oncology
  • Aberdeen Royal Infirmary Oncology Department
  • University Hospitals Bristol Bristol Haematology & Oncology Centre
  • St James's University Hospital
  • Leicester Royal Infirmary The HOPE Clinical Trials Unit
  • Royal Marsden Hospital Department of Medicine
  • Hammersmith Hospital Gary Weston Centre
  • Sarah Cannon Research Institute UK Clinical Trials
  • Imperial Healthcare NHS Trust Charing Cross Hospital
  • Christie Hospital NHS Foundation Trust GI & Endocrine
  • Glan Clwyd Hospital North Wales Cancer Treatment Centre
  • Royal Marsden Hospital Department of Medicine

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

S95005 + Bevacizumab

Capecitabine + Bevacizumab

Arm Description

Outcomes

Primary Outcome Measures

Progression-free Survival (PFS)
Time elapsed between the randomization and the date of radiological tumour progression (according to RECIST 1.1) or death from any cause.

Secondary Outcome Measures

Overall Survival (OS)
Time elapsed between the date of randomization and the date of death due to any cause.
Overall response rate (ORR)
The proportion of patients with objective evidence of complete response (CR) or partial response (PR) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Disease control rate (DCR)
The proportion of patients with objective evidence of CR or PR or stable disease (SD) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Duration of response (DoR)
The time from the first documentation of response (CR or PR) to the first documentation of objective tumour progression or death due to any cause, whichever occurs first.
Time to treatment failure (TTF)
The time from randomization to treatment discontinuation for any reason, including disease progression, treatment toxicity, patient preference, or death.

Full Information

First Posted
February 23, 2018
Last Updated
October 10, 2023
Sponsor
Institut de Recherches Internationales Servier
Collaborators
ADIR, a Servier Group company
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1. Study Identification

Unique Protocol Identification Number
NCT03869892
Brief Title
Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
Acronym
SOLSTICE
Official Title
An Open-label, Randomised, Phase III Study cOmparing trifLuridine/Tipiracil (S 95005) in Combination With Bevacizumab to Capecitabine in Combination With Bevacizumab in firST-line Treatment of Patients With metastatIC Colorectal Cancer Who Are Not candidatE for Intensive Therapy (SOLSTICE Study)
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
March 21, 2019 (Actual)
Primary Completion Date
June 29, 2021 (Actual)
Study Completion Date
June 30, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Institut de Recherches Internationales Servier
Collaborators
ADIR, a Servier Group company

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The main purpose of this study is to demonstrate the superiority of S 95005 in combination with bevacizumab over capecitabine in combination with bevacizumab.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Metastatic Colorectal Cancer
Keywords
Metastatic, Cancer, Colorectal, Colorectal Cancer, Colon, Rectum, Metastasis

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
856 (Actual)

8. Arms, Groups, and Interventions

Arm Title
S95005 + Bevacizumab
Arm Type
Experimental
Arm Title
Capecitabine + Bevacizumab
Arm Type
Active Comparator
Intervention Type
Drug
Intervention Name(s)
Trifluridine/tipiracil hydrochloride (S95005)
Intervention Description
Film-coated tablets of S 95005 (35 mg/m²/dose) will be administered orally twice a day (BID), within 1 hour after completion of morning and evening meals, 5 days on/2 days off, over 2 weeks, followed by a 14-day rest; This treatment cycle will be repeated every 4 weeks.
Intervention Type
Drug
Intervention Name(s)
Capecitabine
Intervention Description
Film-coated tablets, Capecitabine (1250 mg/m²/dose) will be administered orally BID on Days 1-14 of each cycle. This treatment cycle will be repeated every 3 weeks.
Intervention Type
Biological
Intervention Name(s)
Bevacizumab experimental
Intervention Description
Concentrate for solution for infusion, Bevacizumab (5 mg/kg, IV) administered every 2 weeks (Day 1 and Day 15). This treatment cycle will be repeated every 4 weeks.
Intervention Type
Biological
Intervention Name(s)
Bevacizumab control
Intervention Description
Concentrate for solution for infusion, Bevacizumab (7.5 mg/kg, IV) will be administered on Day 1 of each cycle.This treatment cycle will be repeated every 3 weeks.
Primary Outcome Measure Information:
Title
Progression-free Survival (PFS)
Description
Time elapsed between the randomization and the date of radiological tumour progression (according to RECIST 1.1) or death from any cause.
Time Frame
Up to 24 months
Secondary Outcome Measure Information:
Title
Overall Survival (OS)
Description
Time elapsed between the date of randomization and the date of death due to any cause.
Time Frame
Up to 24 months
Title
Overall response rate (ORR)
Description
The proportion of patients with objective evidence of complete response (CR) or partial response (PR) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Time Frame
Up to 24 months
Title
Disease control rate (DCR)
Description
The proportion of patients with objective evidence of CR or PR or stable disease (SD) according to RECIST 1.1 criteria and using investigator's tumour assessment.
Time Frame
Up to 24 months
Title
Duration of response (DoR)
Description
The time from the first documentation of response (CR or PR) to the first documentation of objective tumour progression or death due to any cause, whichever occurs first.
Time Frame
Up to 24 months
Title
Time to treatment failure (TTF)
Description
The time from randomization to treatment discontinuation for any reason, including disease progression, treatment toxicity, patient preference, or death.
Time Frame
Up to 24 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Has definitive histologically confirmed adenocarcinoma of the colon or rectum (all other histological types are excluded). Primary tumour localisation must be known. RAS status based on local biological assessment of tumour biopsy must be available. If RAS status is not available at the time of randomisation, tumour biopsy must be available for RAS status determination (based on local biological assessment). Patient is not a candidate for standard full dose combination chemotherapy with irinotecan or oxaliplatin Patient is not a candidate for curative resection of metastatic lesions. No previous systemic anticancer therapy for unresectable metastatic colorectal cancer. ECOG (Eastern Cooperative Oncology Group) performance status ≤2. Adequate organ function (renal, haematological, hepatic, coagulation) as described in the study protocol' Exclusion Criteria: Pregnancy, breastfeeding or possibility of becoming pregnant during the study. Participation in another interventional study within 4 weeks prior to the randomisation . Patients who have not recovered from clinically relevant non-hematologic CTCAE grade ≥ 3 toxicity of previous anticancer therapy prior to the randomisation. Symptomatic central nervous system metastases. Major surgery within 4 weeks prior to the randomisation. Exclusion criteria related to S 95005 administration: History of allergic reactions attributed to compounds of similar composition to S 95005 or any of its excipients. Any contraindication present in the SmPC of trifluridine/tipiracil Exclusion criteria related to bevacizumab administration: Any contraindication present in the SmPC of bevacizumab Exclusion criteria related to capecitabine administration: Any contraindication present in the SmPC of capecitabine
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Thierry ANDRE, PhD
Organizational Affiliation
Medical Oncology departement Saint-Antoine hospital (Paris France 75012)
Official's Role
Principal Investigator
Facility Information:
Facility Name
Centro de Oncología e Investigación de Buenos Aires COIBA
City
Berazategui
ZIP/Postal Code
B1884BBF
Country
Argentina
Facility Name
Fundación Favaloro Oncology Unit
City
Buenos Aires
ZIP/Postal Code
C1093AAS
Country
Argentina
Facility Name
Instituto Alexander Fleming
City
Ciudad Autonoma de Buenos aires
ZIP/Postal Code
C1426ANZ
Country
Argentina
Facility Name
Hospital Universitario CEMIC Servicio de Oncología, Unidad de tumores gastrointestinales
City
Ciudad Autonoma de Buenos aires
ZIP/Postal Code
C1431FWO
Country
Argentina
Facility Name
Hospital de Gastroenterología Dr. Carlos Borino Udaondo Oncology Unit
City
Ciudad Autónoma de Buenos Aires
ZIP/Postal Code
1264
Country
Argentina
Facility Name
Centro Oncológico Riojano Integral CORI Fundación CORI para la Investigación y Prevención del Cáncer
City
La Rioja
ZIP/Postal Code
F5300COE
Country
Argentina
Facility Name
Fundación COIR Centro Oncológico de Interación Regional
City
Mendoza
ZIP/Postal Code
5500
Country
Argentina
Facility Name
Instituto de Oncología de Rosario
City
Santa Fe
ZIP/Postal Code
S2000KZE
Country
Argentina
Facility Name
ISIS Centro especializado
City
Santa Fe
ZIP/Postal Code
S3000FFU
Country
Argentina
Facility Name
Centro Médico San Roque
City
Tucumán
ZIP/Postal Code
T4000IAK
Country
Argentina
Facility Name
Blacktown Hospital Cancer and Haematology Centre
City
Blacktown
ZIP/Postal Code
2148
Country
Australia
Facility Name
Frankston Private Peninsula and Southeast Oncology Group
City
Frankston
ZIP/Postal Code
3199
Country
Australia
Facility Name
Lake Macquarie Private Hospital
City
Gateshead
ZIP/Postal Code
2290
Country
Australia
Facility Name
St George Hospital St George Hospital Cancer Care Centre
City
Kogarah
ZIP/Postal Code
2217
Country
Australia
Facility Name
Adventist HealthCare Integrated Cancer Centre
City
Wahroonga
ZIP/Postal Code
2076
Country
Australia
Facility Name
Southern Medical Day Care Centre
City
Wollongong
ZIP/Postal Code
2500
Country
Australia
Facility Name
Med. Universität Graz Klinische Abteilung für Onkologie
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Medizinische Universität Innsbruck Univ.-Klinik für Innere Medizin V
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Ordensklinikum Linz Barmherzige Schwestern Interne I
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
Landeskrankenhaus (SALK) Universitätsklinik für Innere Medizin III (SALK)
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Universitätsklinikum St. Pölten Klinische Abteilung für Innere Medizin I
City
St. Poelten
ZIP/Postal Code
3100
Country
Austria
Facility Name
Allgemeines Krankenhaus - Universitätskliniken Klinische Abteilung für Onkologie
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Hospital do Câncer de Barretos - Fundação Pio XII Unidade de Pesquisa Clínica
City
Barretos
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Cenantron - Clinica
City
Belo Horizonte
ZIP/Postal Code
30150-320
Country
Brazil
Facility Name
Sirio Libanes DF - Centro de Oncologia de Braslia do Sirio- Centro Intergrado de Pesquisa
City
Brasília
ZIP/Postal Code
70200-730
Country
Brazil
Facility Name
Centro de Pesquisa Hospital de Caridade de Ijuí Unidade de Pesquisa Clínica
City
Ijuí
ZIP/Postal Code
98700-000
Country
Brazil
Facility Name
Hospital Mae de Deus Oncologia
City
Porto Alegre
ZIP/Postal Code
90880-480
Country
Brazil
Facility Name
Hospital São Rafael Centro Intergrado de Pesquisa
City
Salvador
ZIP/Postal Code
41253-191
Country
Brazil
Facility Name
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncol Centro Intergrado de Pesquisa
City
Santo André
ZIP/Postal Code
09060-870
Country
Brazil
Facility Name
Hospital de Base Centro Integrado de Pesquisa
City
São José Do Rio Preto
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
ICESP - Instituto do Câncer do Estado de São Paulo Centro Integrado de Pesquisa
City
São Paulo
ZIP/Postal Code
01246-000
Country
Brazil
Facility Name
Hospital A C Camargo Unidade de Pesquisa Clinica
City
São Paulo
ZIP/Postal Code
01509-900
Country
Brazil
Facility Name
"Complex oncology center - Burgas" EOOD Department of medical oncology
City
Burgas
ZIP/Postal Code
8000
Country
Bulgaria
Facility Name
"Multiprofile hosp. for active treatmen Dr. Tota Venkova" AD Department of medical oncology
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
Facility Name
"Complex oncology center - Plovdiv" EOOD, IInd base Dpt. of Med. oncology and onc. diseases in gastroenterology
City
Plovdiv
ZIP/Postal Code
4004
Country
Bulgaria
Facility Name
"Spec. hospital for active treatment of oncology dis." EOOD Department of medical oncology and palliative care
City
Sofia
ZIP/Postal Code
1233
Country
Bulgaria
Facility Name
"Medical Center Nadezhda Clinical" EOOD Medical Oncology Department
City
Sofia
ZIP/Postal Code
1330
Country
Bulgaria
Facility Name
"UMHAT Sv. Ivan Rilski" EAD Clinic of clinical hematology, Dpt. of medical oncology
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
MHAT Serdika EOOD Department of Medical Oncology
City
Sofia
ZIP/Postal Code
1632
Country
Bulgaria
Facility Name
Spec. hospital for active treatment of oncology dis. EOOD Department of medical oncology and palliative car
City
Sofia
ZIP/Postal Code
1756
Country
Bulgaria
Facility Name
SHAT of oncology diseases Dr. Marko Antonov Markov" EOOD Department of medical oncology and palliative therapy
City
Varna
ZIP/Postal Code
9003
Country
Bulgaria
Facility Name
"Complex Ongology Center - Vratsa" EOOD Department of Medical oncology
City
Vratsa
ZIP/Postal Code
3000
Country
Bulgaria
Facility Name
Masarykuv onkologicky ustav Klinika komplexni onkologicke pece
City
Brno
ZIP/Postal Code
656 53
Country
Czechia
Facility Name
Fakultni nemocnice Ostrava Klinika onkologicka
City
Ostrava
Country
Czechia
Facility Name
Vseobecna fakultni nemocnice Onkologicka klinika VFN a 1. LF UK
City
Praha
ZIP/Postal Code
128 08
Country
Czechia
Facility Name
Thomayerova nemocnice Onkologicka klinika 1. LF UK a TN
City
Praha
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Fakultni nemocnice Olomouc Onkologicka klinika
City
Praha
ZIP/Postal Code
77900
Country
Czechia
Facility Name
Aalborg Universitetshospital, Syd Onkologisk Afdelin
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
Regionshospitalet Herning, Hospitalsenheden Vest Onkologisk Afdeling
City
Herning
ZIP/Postal Code
7400
Country
Denmark
Facility Name
Rigshospitalet Onkologisk Klinik
City
Kobenhavn
ZIP/Postal Code
2100
Country
Denmark
Facility Name
Odense Universitetshospital Onkologisk Afdeling R
City
Odense
ZIP/Postal Code
5000
Country
Denmark
Facility Name
East Tallinn Central Hospital Center of Oncology
City
Tallinn
ZIP/Postal Code
11312
Country
Estonia
Facility Name
North Estonia Medical Centre Foundation Oncology and Haematology clinic
City
Tallinn
ZIP/Postal Code
13419
Country
Estonia
Facility Name
Tartu University Hospital, Hematology - Oncology clinic, Radiotherapy and oncological therapy
City
Tartu
ZIP/Postal Code
51014
Country
Estonia
Facility Name
Institut Sainte Catherine
City
Avignon
ZIP/Postal Code
84918
Country
France
Facility Name
CHU Jean Minjoz Service d'oncologie médicale
City
Besancon
ZIP/Postal Code
25030
Country
France
Facility Name
CHU Morvan Institut de Cancérologie et d'Hématologie
City
Brest
ZIP/Postal Code
29200
Country
France
Facility Name
Hopital Privé Jean Mermoz Service de Gastro entérologie et d'Oncologie médicale
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Hôpital Nord Franche-Comté - Site du Mittan Service d'oncologie médicale
City
Montbeliard
ZIP/Postal Code
25209
Country
France
Facility Name
Centre Antoine Lacassagne Dpt d'Oncologie Médicale
City
Nice
ZIP/Postal Code
06189
Country
France
Facility Name
Hôpital Saint-Antoine Service d'Oncologie Médicale
City
Paris
ZIP/Postal Code
75012
Country
France
Facility Name
Hôpital Européen Georges Pompidou Oncologie Hépatogastroenterologie-oncologie digestive
City
Paris
ZIP/Postal Code
75015
Country
France
Facility Name
Hopital Haut-Leveque Hepato-gastroenterologie et oncologie digestive
City
Pessac
ZIP/Postal Code
33604
Country
France
Facility Name
CHU Toulouse Rangueil Oncologie médicale digestive
City
Toulouse
ZIP/Postal Code
31059
Country
France
Facility Name
Onkologische Schwerpunktpraxis Kurfuerstendamm
City
Berlin
ZIP/Postal Code
10707
Country
Germany
Facility Name
Lübecker Onkologische Schwerpunktpraxis im Hochschulstadttei
City
Luebeck
ZIP/Postal Code
23562
Country
Germany
Facility Name
Klinikum der Universität München Campus Großhadern, Medizinische Klinik und Poliklinik III
City
Muenchen
ZIP/Postal Code
81377
Country
Germany
Facility Name
Magyar Honvedseg Egeszsegugyi Kozpont Onkologiai Osztaly
City
Budapest
ZIP/Postal Code
1062
Country
Hungary
Facility Name
Semmelweis University Radiology and Oncotherapy Clinic
City
Budapest
ZIP/Postal Code
1083
Country
Hungary
Facility Name
Del-Pesti Centrumkh-Orsz. Hematologiai es Infektologiai Int. Szent Laszlo Telephely
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Szent Imre Egyetem Oktatokorhaz Klinikai Onkologia
City
Budapest
ZIP/Postal Code
1115
Country
Hungary
Facility Name
Orszagos Onkologiai Intezet "B" Belgyogyaszati-Onkologiai O. Es Klin. Farmakologiai O.
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Uzsoki Utcai Korhaz Onkoradiologiai Osztaly
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Debreceni Egyetem Orvos es Egeszsegtudomanyi Centrum Onkologiai Intezet
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Bekes Megyei Kozponti Korhaz
City
Gyula
ZIP/Postal Code
57000
Country
Hungary
Facility Name
Petz Aladar Megyei Oktato Korhaz Onkoradiologiai Osztaly
City
Győr
ZIP/Postal Code
9024
Country
Hungary
Facility Name
Bacs-Kiskun Megyei Korhaz Onkoradiologiai Kozpont
City
Kecskemét
ZIP/Postal Code
6000
Country
Hungary
Facility Name
Szabolcs-Szatmar-Bereg Megyei Korhazak Onkoradiologiai Osztaly
City
Nyíregyháza
ZIP/Postal Code
4400
Country
Hungary
Facility Name
Pecsi Tudomanyegyetem, Klinikai Kozpont Onkoterapias Intezet
City
Pécs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kp. Onkoterápiás Klinika
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
JNSZ Megyei Hetenyi Geza Korhaz es Rendelointezet Megyei Onkologiai Centrum
City
Szolnok
ZIP/Postal Code
5004
Country
Hungary
Facility Name
Markusovsky Egyetemi Oktatokorhaz Onkoradiologiai Osztaly
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
Zala Megyei Korhaz Onkologiai osztaly
City
Zalaegerszeg
ZIP/Postal Code
8900
Country
Hungary
Facility Name
Bon Secours Hospital
City
Cork
ZIP/Postal Code
90
Country
Ireland
Facility Name
Cork University Hospital Department of Medical Oncology
City
Cork
ZIP/Postal Code
T12 DC4A
Country
Ireland
Facility Name
The Adelaide and Meath Hospital
City
Dublin
ZIP/Postal Code
D24 NROA
Country
Ireland
Facility Name
Azienda Policlinico Universitaria - Presidio Monserrato Oncologia Medica
City
Cagliari
ZIP/Postal Code
09100
Country
Italy
Facility Name
Azienda Socio Sanitaria Territoriale di Cremona ONCOLOGIA
City
Cremona
ZIP/Postal Code
26100
Country
Italy
Facility Name
Istituto Nazionale Tumori I.R.C.C.S "Fondazione G. Pascale" Struttura Complessa di Oncologia Medica Addominale
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Istituto Oncologico Veneto IOV - IRCCS Unità Operativa Complessa Oncologia Medica 1
City
Padova
ZIP/Postal Code
35128
Country
Italy
Facility Name
A.O.U. Pisana-Ospedale Santa Chiara U.O. di Oncologia Medica 2
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Ospedale San Carlo U.O. Oncologia Medica
City
Potenza
ZIP/Postal Code
85100
Country
Italy
Facility Name
Arcispedale Santa Maria Nuova Unità di Oncologia
City
Reggio Emilia
ZIP/Postal Code
42123
Country
Italy
Facility Name
Policlinico Universitario Campus Biomedico UOC di Oncologia Medica
City
Roma
ZIP/Postal Code
00128
Country
Italy
Facility Name
Istituto Clinico Humanitas I.R.C.C.S Dipartimento di Oncologia Medica ed Ematologia
City
Rozzano (mi)
ZIP/Postal Code
20089
Country
Italy
Facility Name
IRCSS Casa Sollievo della Sofferenza Dipartimento Onco-Ematologia
City
San Giovanni Rotondo
ZIP/Postal Code
71013
Country
Italy
Facility Name
Ospedale S. Bortolo -ULSS8 Berica Distretto Est U.O. ONCOLOGIA
City
Vicenza
ZIP/Postal Code
36100
Country
Italy
Facility Name
P. Stradins Clinical University Hospital
City
Riga
ZIP/Postal Code
1002
Country
Latvia
Facility Name
Riga East Univerity Hospital Oncology Centre of Latvia
City
Riga
ZIP/Postal Code
1079
Country
Latvia
Facility Name
Oncology Hospital, Branch of Hospital of Lithuanian Uni. of Health Sciences Kauno klinikos
City
Kaunas
ZIP/Postal Code
45434
Country
Lithuania
Facility Name
Hospital of Lithuania Univ of Health Sciences Kauno klinikos Oncology Institute
City
Kaunas
ZIP/Postal Code
LT-50161
Country
Lithuania
Facility Name
Klaipeda University hospital
City
Klaipėda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
National Cancer Institute
City
Vilnius
ZIP/Postal Code
LT-08660
Country
Lithuania
Facility Name
Rijnstate Oncologie
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Albert Schweitzer Ziekenhuis Interne Geneeskunde
City
Dordrecht
ZIP/Postal Code
3318 AT
Country
Netherlands
Facility Name
Catharina Ziekenhuis Interne Gesneeskunde/Oncologie
City
Eindhoven
ZIP/Postal Code
5623 EJ
Country
Netherlands
Facility Name
Ikazia Ziekenhuis Oncologie
City
Rotterdam
ZIP/Postal Code
3083 AN
Country
Netherlands
Facility Name
ETZ Elisabeth Interne Geneeskunde
City
Tilburg
ZIP/Postal Code
5022 GC
Country
Netherlands
Facility Name
Bernhoven Interne Geneeskunde
City
Uden
ZIP/Postal Code
5406 PT
Country
Netherlands
Facility Name
Bialostockie Centrum Onkologii im Marii Curie-Sklodowskiej Oddzial Onkologii Klinicznej im Dr Ewy Pileckiej z pododdzialem Chemioterapii Dziennej
City
Białystok
ZIP/Postal Code
15-027
Country
Poland
Facility Name
Uniwersyteckie Centrum Kliniczne Klinika Onkologii i Radioterapii
City
Gdańsk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Przychodnia Lekarska "KOMED"
City
Konin
ZIP/Postal Code
62-500
Country
Poland
Facility Name
SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii Oddzial Kliniczny Onkologii i Immunoonkologii
City
Olsztyn
ZIP/Postal Code
10-228
Country
Poland
Facility Name
Opolskie Centrum Onkologii im. Tadeusza Koszarowskiego Oddzial Onkologii Klinicznej
City
Opole
ZIP/Postal Code
45-061
Country
Poland
Facility Name
Wielkopolskie Centrum Onkologii im Marii Sklodowskiej-Curie Oddzial Chemioterapii
City
Poznań
ZIP/Postal Code
61-866
Country
Poland
Facility Name
NU-MED Centrum Diagnostyki i Terapii Onkologicznej Tomaszów Mazowiecki II Sp. z o.o., Pododdzial Chemioterapi
City
Tomaszów Mazowiecki
ZIP/Postal Code
97-200
Country
Poland
Facility Name
M. Kopernika Provincial Hospital Oddzial Chemioterapii Nowotworow
City
Łódź
ZIP/Postal Code
93-513
Country
Poland
Facility Name
Hospital Garcia de Orta Serviço de Oncologia Médica
City
Almada
ZIP/Postal Code
2805-267
Country
Portugal
Facility Name
Centro Hospitalar e Universitário de Coimbra - CHUC Unidade de Inovação e Desenvolvimento (UID)
City
Coimbra
ZIP/Postal Code
3000-075
Country
Portugal
Facility Name
Centro Hospitalar Lisboa Norte, Hospital de Santa Maria Serviço de Oncologia Médica
City
Lisboa
ZIP/Postal Code
1649-035
Country
Portugal
Facility Name
Hospital Beatriz Ângelo Serviço de oncologia medic
City
Loures
ZIP/Postal Code
2674-514
Country
Portugal
Facility Name
Instituto Português de Oncologia do Porto FG, EPE -IPO Porto Medical Oncology Dept.
City
Porto
ZIP/Postal Code
4200-072
Country
Portugal
Facility Name
Institutul Oncologic "Prof Alexandru Trestioreanu" Busuresti Sectia Oncologie Medicala I
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Spitalul Clinic "Coltea" Sectia Oncologie Medicala
City
Bucuresti
ZIP/Postal Code
030171
Country
Romania
Facility Name
Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj Napoca Oncologie Medicala
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Centrul de Oncologie Sf Nectarie Oncology Department
City
Craiova
ZIP/Postal Code
200347
Country
Romania
Facility Name
S.C Oncolab S.R.L Sectia Oncologie Medicala
City
Craiova
ZIP/Postal Code
200385
Country
Romania
Facility Name
Institutul Regional de Oncologie Iasi Clinica de Oncologie Medicala
City
Iaşi
ZIP/Postal Code
700483
Country
Romania
Facility Name
Spitalul Clinic Judetean de Urgenta Sibiu Sectia Oncologie Medicala
City
Sibiu
ZIP/Postal Code
550245
Country
Romania
Facility Name
S.C ONCOMED S.R.L Departament Oncologie Medicala
City
Timişoara
ZIP/Postal Code
300239
Country
Romania
Facility Name
Arkhangelsk Clinical Oncology Dispensary chemotherapy department
City
Arkhangel'sk
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
Clinical Oncology Dispensary No.1 Chemotherapy Department
City
Krasnodar
ZIP/Postal Code
350040
Country
Russian Federation
Facility Name
Kursk Regional Clinical Oncology Dispensary Oncology Department
City
Kursk
ZIP/Postal Code
305524
Country
Russian Federation
Facility Name
Russian Cancer Research Center n.a. NN Blokhin Clinical Pharmacology and Chemotherapy
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
University Headache Clinic Outpatient oncology clinic
City
Moscow
ZIP/Postal Code
121467
Country
Russian Federation
Facility Name
Moscow City Oncology Hospital # 62 chemotherapy department
City
Moscow
ZIP/Postal Code
143423
Country
Russian Federation
Facility Name
Omsk Clinical Oncologic Dispensary Chemotherapy
City
Omsk
ZIP/Postal Code
644046
Country
Russian Federation
Facility Name
Pyatigorsk Interdistrict Oncology Dispensary Chemotherapy department
City
Pyatigorsk
ZIP/Postal Code
357502
Country
Russian Federation
Facility Name
Rostov Research Institute of Oncology Chemotherapy department
City
Rostov-on-Don
ZIP/Postal Code
344037
Country
Russian Federation
Facility Name
Regional Clinical Oncology Dispensary
City
Ryazan'
ZIP/Postal Code
390011
Country
Russian Federation
Facility Name
Scientific Centre for Specialized Medical Care (oncological) Chemotherapy
City
Saint Petersburg
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
National Medical Research Center of Oncology N.N. Petrova
City
Saint Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Saint Petersburg City Oncology Clilnic
City
Saint Petersburg
ZIP/Postal Code
198255
Country
Russian Federation
Facility Name
Multidisciplinary clinic "Reaviz"
City
Samara
ZIP/Postal Code
443011
Country
Russian Federation
Facility Name
Oncology Dispensary No.2
City
Sochi
ZIP/Postal Code
354057
Country
Russian Federation
Facility Name
State Research Institution of Oncology of Tomsk Chemotherapy
City
Tomsk
ZIP/Postal Code
634024
Country
Russian Federation
Facility Name
SBIH of YR "Clinical oncology hospital" chemotherapy department
City
Yaroslavl
ZIP/Postal Code
150054
Country
Russian Federation
Facility Name
Narodny onkologicky ustav Oddelenie klinickej onkologie
City
Bratislava
ZIP/Postal Code
833 10
Country
Slovakia
Facility Name
Vychodoslovensky onkologicky ustav Oddelenie klinickej onkologie
City
Košice
ZIP/Postal Code
04191
Country
Slovakia
Facility Name
Hospital General Universitario Alicante Servicio de Oncología
City
Alicante
ZIP/Postal Code
03010
Country
Spain
Facility Name
Hospital Germans Trias i Pujol Unidad de Investigación clínica (UIC) ICO-Oncología medica
City
Badalona
ZIP/Postal Code
08916
Country
Spain
Facility Name
H. Valle de Hebrón Servicio de Oncología - (VHIR)
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Hospital de la Santa Creu I Sant Pau Oncología Medica
City
Barcelona
ZIP/Postal Code
08041
Country
Spain
Facility Name
Hospital Uni. Reina Sofía - Hospital Provincial Departamento de Oncología Médica
City
Córdoba
ZIP/Postal Code
14004
Country
Spain
Facility Name
INSTITUTO CATALAN DE ONCOLOGÍA - ICO Oncología Médica
City
Hospitalet de Llobregat
ZIP/Postal Code
08908
Country
Spain
Facility Name
Hospital Unviersitario Gregorio Marañon Servicio de Oncología Médica
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Universitario Ramón y Cajal, Servicio de Oncologia Médica
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
H. Clínico San Carlos Servicio de Oncología Médica
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
HOSPITAL 12 DE OCTUBRE Servicio Oncología Médica
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
H. Universitario La Paz Oncología Médica
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Universitario Marqués de Valdecilla Oncología médica
City
Santander
ZIP/Postal Code
39008
Country
Spain
Facility Name
H.Virgen Del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Hospital Quirónsalud Valencia Servicio de Oncología Médica
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Hospital Universitario Miguel Servet Servicio de Oncología
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Falu Lasarett Onkologmottagningen
City
Falun
ZIP/Postal Code
791 82
Country
Sweden
Facility Name
Lanssjukhuset Ryhov Onkologiska kliniken
City
Jönköping
ZIP/Postal Code
551 85
Country
Sweden
Facility Name
Karolinska University Hospital, Solna Studiebehandlingsenheten, B8:09
City
Solna
ZIP/Postal Code
171 64
Country
Sweden
Facility Name
Norrlands Universitetssjukhus Cancercentrum Umea
City
Umeå
ZIP/Postal Code
901 85
Country
Sweden
Facility Name
Universitetssjukhuset Orebro
City
Örebro
ZIP/Postal Code
701 85
Country
Sweden
Facility Name
Cherkasy Regional Oncological Dispensary Regional Clinical Oncological Centre
City
Cherkasy
ZIP/Postal Code
18009
Country
Ukraine
Facility Name
Dnipro Regional Oncology Dispensary
City
Dnipro
ZIP/Postal Code
49055
Country
Ukraine
Facility Name
MI "Dnipropetrovsk City Multi-field Clinical Hospital #4" Department of Oncology
City
Dnipro
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Institute of Medical Radiology of S.P. Grygoryev of AMS UKR
City
Kharkiv
ZIP/Postal Code
61024
Country
Ukraine
Facility Name
National Institute of Cancer Abdominal Oncology Department
City
Kyiv
ZIP/Postal Code
03022
Country
Ukraine
Facility Name
Kyiv City Clinical Oncology Centre Chemotherapy Department #2
City
Kyiv
ZIP/Postal Code
03115
Country
Ukraine
Facility Name
Municipal Institution of Kyiv Regional Council "Kyiv Regional Clinical Hospital", proctology department
City
Kyiv
ZIP/Postal Code
04107
Country
Ukraine
Facility Name
Lviv Regional Oncology Center Chemotherapy department
City
Lviv
ZIP/Postal Code
79031
Country
Ukraine
Facility Name
Odesa Regional Oncology Dispensary Day patient Department
City
Odesa
ZIP/Postal Code
65010
Country
Ukraine
Facility Name
Podillia Regional Oncology Centre Chemotherapy Department
City
Vinnytsya
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
Regional Clinical Oncological Dispensary Department of Oncology
City
Zaporozhye
ZIP/Postal Code
69000
Country
Ukraine
Facility Name
Aberdeen Royal Infirmary Oncology Department
City
Aberdeen
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Facility Name
University Hospitals Bristol Bristol Haematology & Oncology Centre
City
Bristol
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
St James's University Hospital
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Leicester Royal Infirmary The HOPE Clinical Trials Unit
City
Leicester
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
Royal Marsden Hospital Department of Medicine
City
London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Facility Name
Hammersmith Hospital Gary Weston Centre
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Facility Name
Sarah Cannon Research Institute UK Clinical Trials
City
London
ZIP/Postal Code
W1G 6AD
Country
United Kingdom
Facility Name
Imperial Healthcare NHS Trust Charing Cross Hospital
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Facility Name
Christie Hospital NHS Foundation Trust GI & Endocrine
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Glan Clwyd Hospital North Wales Cancer Treatment Centre
City
Rhyl
ZIP/Postal Code
LL18 5UJ
Country
United Kingdom
Facility Name
Royal Marsden Hospital Department of Medicine
City
Sutton
ZIP/Postal Code
SM2 5PT
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Qualified scientific and medical researchers can request access to anonymized patient-level and study-level clinical trial data. Access can be requested for all interventional clinical studies: used for Marketing Authorization (MA) of medicines and new indications approved after 1 January 2014 in the European Economic Area (EEA) or the United States (US). where Servier is the Marketing Authorization Holder (MAH). The date of the first MA of the new medicine (or the new indication) in one of the EEA Member States will be considered for this scope. In addition, access can be requested for all interventional clinical studies in patients: sponsored by Servier with a first patient enrolled as of 1 January 2004 onwards for New Chemical Entity or New Biological Entity (new pharmaceutical form excluded) for which development has been terminated before any Marketing authorization (MA) approval.
IPD Sharing Time Frame
After Marketing Authorisation in EEA or US if the study is used for the approval.
IPD Sharing Access Criteria
Researchers should register on Servier Data Portal and fill in the research proposal form. This form in four parts should be fully documented. The Research Proposal Form will not be reviewed until all mandatory fields are completed.
IPD Sharing URL
https://clinicaltrials.servier.com/
Links:
URL
https://clinicaltrials.servier.com/wp-content/uploads/CL3-095005-006-laysummary-2022.02.10.pdf
Description
First Lay Summary
URL
https://clinicaltrials.servier.com/wp-content/uploads/CL3-095005-006-anonymisedsynopsis-2021.12.17.pdf
Description
First Results Summary
Available IPD and Supporting Information:
Available IPD/Information Type
Individual Participant Data Set
Available IPD/Information URL
https://clinicaltrials.servier.com/
Available IPD/Information Type
Study Protocol
Available IPD/Information URL
https://clinicaltrials.servier.com/
Available IPD/Information Type
Statistical Analysis Plan
Available IPD/Information URL
https://clinicaltrials.servier.com/
Available IPD/Information Type
Informed Consent Form
Available IPD/Information URL
https://clinicaltrials.servier.com/
Available IPD/Information Type
Clinical Study Report
Available IPD/Information URL
https://clinicaltrials.servier.com/
Available IPD/Information Type
study-level clinical trial data
Available IPD/Information URL
https://clinicaltrials.servier.com/

Learn more about this trial

Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.

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