Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
About this trial
This is an interventional basic science trial for Glaucoma, Open-Angle
Eligibility Criteria
Inclusion criteria
Patients with primary open angle glaucoma
- Diagnosis of manifest primary open angle glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- Untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- Mean deviation in the visual field test is less than or equal 10dB (for one group) OR more than 10dB (for the other group)
Patients with normal tension glaucoma
- Diagnosis of manifest normal tension glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- No evidence of untreated IOP > 20 mmHg in the medical history
- Mean deviation in the visual field is less than or equal 10dB (for one group) OR more than 10dB (for the other group)
Patients with ocular hypertension
- Normal ophthalmic findings except presence of ocular hypertension defined as untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test
Healthy control subjects
- Normal ophthalmic findings
- IOP < 20 mmHg on least three measurements
- No evidence of increased IOP in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test
Exclusion criteria
- History of a severe medical condition as judged by the clinical investigator
- Abuse of alcoholic beverages
- Smoker
- Participation in a clinical trial in the 3 weeks preceding the study
- Exfoliation glaucoma, pigmentary glaucoma, history of acute angle closure
- Intraocular surgery within the last 6 months
- Ocular inflammation or infection within the last 3 months
- History of epilepsia
- Diabetes mellitus
- Untreated hypertension with systolic blood pressure > 160 mmHg, diastolic blood pressure > 95 mmHg
- Pregnancy
- Planned pregnancy or lactating
Sites / Locations
- Department of Clinical Pharmacology, Medical University of ViennaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
POAG MD<10dB
POAG MD>10dB
NTG MD<10dB
NTG MD>10dB
OHT
controls
patients with primary open angle glaucoma with MD in visual field less than or equal 10dB
patients with primary open angle glaucoma with MD in visual field more than 10dB
patients with normal tension glaucoma with MD in visual field less than or equal 10dB
patients with normal tension glaucoma with MD in visual field more than 10dB
patients with ocular hypertension
healthy, age and sex matched, control subjects