Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)
Coronary Heart Disease (CHD)
About this trial
This is an interventional treatment trial for Coronary Heart Disease (CHD) focused on measuring High Cardiovascular Risk, No prior Myocardial Infarction stroke, >= 50 years of age (men), >= 55 years of age (women), lipid-lowering therapy
Eligibility Criteria
Inclusion criteria:
- Age: Adult subjects ≥ 50 (men) or ≥ 55 (women) to ˂ 80 years of age (either sex) and meeting lipid criteria
- Low-density lipoprotein cholesterol (LDL-C) ≥ 90 mg/dL (≥ 2.3 mmol/L) or non-high-density lipoprotein cholesterol (non-HDL) ≥ 120 mg/dL (≥ 3.1 mmol/L), or apolipoprotein B ≥ 80 mg/dL (≥ 1.56 µmol/L)
Evidence of at least one of the following at screening (without prior myocardial infarction or stroke):
A. Significant coronary artery disease (CAD) B. Significant atherosclerotic cerebrovascular disease C. Significant peripheral arterial disease D. Diabetes mellitus
- At least 1 high-risk feature
Exclusion criteria
- MI or stroke prior to randomization
- Coronary artery bypass grafting (CABG) ˂ 3 months prior to screening
- Estimated glomerular filtration rate (eGFR) ˂ 15 mL/min/1.73 m²
- Uncontrolled or recurrent ventricular tachycardia in the absence of an implantable-cardioverter defibrillator.
- Atrial fibrillation or atrial flutter not on anticoagulation therapy (vitamin K antagonist, heparin, low molecular weight heparin, fondaparinux,or non-Vitamin K antagonist oral anticoagulant)
- Triglycerides ≥ 500 mg/dL (5.7 mmol/L) measured up to 3 months prior to screening. The most recent results must be used.
- Last measured left-ventricular ejection fraction ˂ 30% or New York Heart Association (NYHA) Functional Class III/IV
- Planned arterial revascularization
Sites / Locations
- North Alabama Research Center LLC
- Cardiovascular Associates
- Heart Center Research LLC
- Mobile Heart Specialists PC
- Arkansas Cardiology
- Central Arkansas Veterans Healthcare System
- Cardiovascular Research Foundation of Southern California
- Westside Medical Associates of Los Angeles
- West Coast Research LLC
- Desert Oasis Healthcare Medical Group
- Covigilant Research, LLC
- Sierra Clinical Research
- Center for Clinical Trials of Sacramento Inc
- Harbor University of California Los Angeles Medical Center
- Optumcare Colorado Springs LLC
- University of Colorado Memorial Health System
- New West Physicians
- South Denver Cardiology Associates
- Cardiology Associates of Fairfield County, PC
- Excel Medical Clinical Trials
- Bay Area Cardiology
- Nature Coast Clinical Research LLC
- Daytona Heart Group
- Cardiology Research Associates
- Complete Health Research
- Cohen Medical Associates PA
- Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
- George E Platt MD
- Research Physicians Network Alliance
- Baptist Health Research Institute
- University of Florida and Shands Hospital
- Jacksonville Center for Clinical Research
- First Coast Cardiovascular Institute PA
- Gad Research Center
- Cardiovascular Research Center of South Florida
- Ocala Research Institute, Inc
- Cardiology Consultants
- Charlotte Heart Group Research Center
- Intercoastal Medical Group
- Cardiovascular Center of Sarasota
- Florida Cardiology Group
- The Florida Lipid Institute
- NSC Research
- Kootenai Heart Clinics, LLC
- Northwest Heart Clinical Research LLC
- Deaconess Clinic
- LaPorte County Institute for Clinical Research
- Midwest Cardiovascular Research Foundation
- The University of Iowa College of Public Health
- MercyOne Iowa Heart Center
- The University of Kansas Medical Center
- Saint Elizabeth Covington
- The Research Group of Lexington LLC
- Alexandria Cardiology Clinic
- Grace Research LLC
- Horizon Research Group of Opelousas LLC
- Louisiana Heart Center
- Barnum Medical Research
- Grace Research LLC
- Louisiana Heart Center
- Northern Light Eastern Maine Medical Center
- Southern Maine Health Care
- Maryland Cardiovascular Specialists
- Metropolitan Cardiovascular Consultants LLC
- TidalHealth Peninsula Regional, Inc
- Brigham and Womens Hospital
- Charles River Medical Associates
- East Mountain Medical Associates, PC
- Baystate Health Center
- Ahmed Arif Medical Research Center LLC
- Healthy Heart Cardiology
- Rajendra H Mehta, MD, PC
- Munson Medical Center
- Saint Marys Medical Center
- Minneapolis Heart Institute Foundation
- Saint Cloud Hospital
- HealthEast Medical Research Institute
- Kansas City Veterans Affairs Medical Center
- Mercy Research
- Great Falls Clinic LLP
- Bryan Heart
- Nebraska Western Iowa Health Care System
- Palm Research Center Inc
- Virtua Health, Inc.
- Healthwise Medical Associates
- Trinity Medical Western New York, PC
- WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
- Northwell Health Physician Partners Cardiology
- North Shore Diabetes and Endocrine Associates
- Northwell Health Lenox Hill Heart and Vascular
- Hudson Valley Cardiovascular Physicians PC
- Saratoga Clinical Research, LLC
- Division of Cardiovascular Research at Peconic Bay Medical Center
- Asheville Cardiology Associates
- University of North Carolina at Chapel Hill
- Novant Health Heart and Vascular Institute
- Moses H Cone Memorial Hospital
- Crossroads Clinical Research Inc
- Piedmont Medical Group Research of Rocky Mount
- PMG Research of Salisbury
- Novant Health Forsyth Medical Center
- Wake Forest University Health Sciences
- Lillestol Research LLC
- The Christ Hospital
- University Hospitals Cleveland Medical Center
- North Ohio Heart Center
- Sanjay Vora Research LLC
- North Ohio Heart Center-Sandusky
- Heart House Research Foundation
- Intend Research
- Oklahoma Heart Institute
- Oregon Health and Science University
- Capital Area Research LLC
- Geisinger Holy Spirit
- Doylestown Health Cardiology
- Lycoming Internal Medicine Inc
- Perelman Center for Advanced Medicine
- Cardiology Consultants of Philadelphia CCP
- University of Pittsburgh Medical Center
- Miriam Hospital
- Pharmacorp Clinical Trials Inc
- Piedmont Research Partners
- Tribe Clinical Research LLC DBA Mountain View Clinical Research
- Main Street Physicians Care Waterway
- The Diabetes Center
- Palmetto Clinical Research
- Monument Health Clinical Research
- Parkway Cardiology Associates
- Soltero Cardiovascular Research Center
- Southwest Family Medicine Associates
- Humble Cardiology Associates
- Texas Cardiology Associates of Houston
- Texas Institute for Kidney and Endocrine Disorders
- Texas Institute of Cardiology
- Southern Endocrinology Associates PA
- Permian Research Foundation
- South Texas Cardiovascular Consultants PLLC
- Mercury Medical Conversions LTD
- Northwest Houston Heart Center
- Alpine Research Organization
- Suffolk Multispecialty Research LLC
- Selma Medical Associates
- Multicare Institute for Research and Innovation
- Universal Research Group LLC
- Aspirus Research Institute
- Instituto de Investigaciones Clinicas Bahia Blanca
- Stat Research
- Cinme - Centro de Investigaciones Metabolicas
- Ciprec - Centro de Investigacion y Prevencion Cardiovascular
- Consultorio Medico Dr Litvak Bruno
- Centro de Especialidades Medicas - Cemedic
- Centro Medico Laura Maffei
- Cardiología Palermo
- Cedic - Centro de Investigacion Clinica
- Centro Medico Dra De Salvo
- Fundacion Respirar
- Instituto de Investigaciones Metabolicas - Idim
- Hospital Universitario Fundacion Favaloro
- Icba - Instituto Cardiovascular de Buenos Aires
- Glenny Corp SA
- Instituto de Investigaciones Clinicas Mar del Plata
- Ciad - Consultorio Integral de Atencion al Diabetico
- Dim Clinica Privada
- Instituto de Investigaciones Clinicas de San Nicolas
- Instituto de Investigaciones Clinicas Zarate
- Clinica Privada del Prado
- Clinica Fusavim Privada SRL
- Sanatorio Santa Rosa Srl
- Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
- Sanatorio Plaza
- Centro Modelo de Cardiologia
- Clinical Mayo de Urgencias Medicas Cruz Blanca SRL
- Instituto de Cardiologia de Corrientes Juana Francisca Cabral
- Instituto Medico DAMIC - Fundacion Rusculleda
- Cordis Sa
- Clinica El Castano
- Instituto Cardiovascular San Luis
- Centro de Investigaciones Clinicas del Litoral
- Canberra Hospital
- Royal Prince Alfred Hospital
- Liverpool Hospital
- Australian Clinical Research Network
- Heartcare Partners
- Bundaberg Cardiology
- Holdsworth House Medical Brisbane
- Core Research Group Pty Ltd
- Heart and Vascular Research
- Royal Adelaide Hospital
- SA Heart
- Adelaide Cardiology Practice - Leabrook Clinic
- Royal Hobart Hospital
- HeartCare Victoria - Berwick
- Monash Medical Centre
- The Cardiologists Proprietary Limited
- Barwon Health Geelong Hospital
- GenesisCare Ringwood
- Curtin University Centre of Clinical Research and Education
- HeartCare Western Australia - Joondalup
- Fiona Stanley Hospital
- Dr Heart Pty Ltd
- Landeskrankenhaus Feldkirch
- Medizinische Universitaet Graz
- Medizinische Universitaet Innsbruck
- Klinikum Klagenfurt am Woerthersee
- Ordensklinikum Linz Barmherzige Schwestern
- Klinik Landstrasse
- Zentrum fuer klinische Studien - Dr Hanusch GmbH
- Universitaetsklinikum Allgemeines Krankenhaus Wien
- Klinik Hietzing
- Klinik Ottakring
- Algemeen Stedelijk Ziekenhuis Aalst
- Onze Lieve Vrouw Ziekenhuis - campus Aalst
- Ziekenhuis Netwerk Antwerpen Middelheim
- Ziekenhuis Netwerk Antwerpen Stuivenberg
- Universite Catholique de Louvain Cliniques Universitaires Saint Luc
- AZ Sint Blasius
- Algemeen Ziekenhuis Sint Lucas
- Medif sprl
- Dokter Mortelmans bvba
- Jessa Ziekenhuis - Campus Virga Jesse
- Universitair Ziekenhuis Leuven - Campus Gasthuisberg
- Medilink sprl
- Centre Hospitalier Universitair Ambroise Pare
- Maria Ziekenhuis Noord-Limburg
- Testumed vzw
- Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
- Centro de Pesquisa Clinica do Brasil
- Cardresearch Cardiologia Assistencial de Pesquisa
- Fundaçao Hospitalar Sao Francisco de Assis
- Eurolatino Pesquisas Medicas
- Sociedade Hospitalar Angelina Caron
- Quanta Diagnosticos e Terapia
- Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter
- Nucleo de Pesquisa Clinica
- Núcleo de Pesquisa em Cirurgia Vascular
- Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
- Hospital Nossa Senhora da Conceicao
- AngioCor Blumenau
- Centro Especializado em Cardiologia
- Instituto de Pesquisa Clinica de Campinas
- Instituto do Coracao de Marilia
- Centro de Pesquisas Clinicas Cpclin
- Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
- IBPClin Instituto Brasil de Pesquisa Clinica
- Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
- Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
- Multiprofile Hospital for Active Treatment - Haskovo AD
- Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD
- Medical Center Medconsult OOD
- University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
- University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
- Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD
- Fifth Multiprofile Hospital for Active Treatment - Sofia EAD
- National Multiprofile Transport Hospital Tzar Boris III
- Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD
- Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD
- Medical Center Excelsior OOD
- University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
- University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD
- Diagnostic-Consultative Center Convex EOOD
- Medical Center Kalimat EOOD
- Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD
- Medical Center Orpheus OOD
- Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
- LMC Clinical Research Incorporated
- SMH Cardiology Clinical Trials Incorporated
- Dr T G Elliott Incorporated - BC Diabetes
- Winnipeg Clinic
- G A Research Associates Limited
- Commonwealth Medical Clinic
- Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
- Heart Health Institute
- LMC Clinical Research Incorporated
- LMC Clinical Research Incorporated
- Brampton Clinical Trials
- LMC Clinical Research Incorporated Thornhill
- LMC Clinical Research Incorporated
- Hamilton Health Sciences Hamilton General Hospital
- Western Centre for Public Health and Family Medicine - Western University
- My Endo Diabetes and Endocrinology Center
- LMC Clinical Research Incorporated
- Partners in Advanced Cardiac Evaluation
- SKDS Research Incorporated
- Oakville Cardiovascular Research
- Dr James Cha
- Kawartha Cardiology Clinical Trials
- Bluewater Clinical Research Group Incorporated
- Heart Health Institute Research Incorporated
- Corcare Cardiovascular Research
- Womens College Hospital
- North York Diagnostic and Cardiac Centre
- Office of Dr Louis Yao
- Ecogene-21
- Manna Research Incorporated
- Clinique Sante Cardio MC
- Institut de recherches cliniques de Montreal
- McGill University Health Centre - Montreal General Hospital
- Applied Medical Informatics Research Incorporated
- Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
- Clinique des Maladies Lipidiques de Quebec Incorporated
- MUDr Igor Karen
- Jessenia as, Nemocnice Beroun
- Medicentrum Beroun sro
- Medicus Services sro
- Amkardia sro
- CCR Brno sro
- Centrum pro zdravi sro
- Kardiologicka ambulance Brno sro
- Fakultni nemocnice Brno
- Vojenska nemocnice Brno
- prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance
- Edumed sro, Kardiologicka ambulance
- Cevni centrum Ceske Budejovice sro
- Dika centrum sro
- Clinical Trial Center Hodonin sro
- Kardio Holesov sro
- MUDr Ladislava Harrerova, kardiologicka ordinace
- Karlovarska krajska nemocnice
- Oblastni nemocnice Kladno as
- Kardio Michal Cepelak sro
- Oblastni nemocnice Kolin as
- Krajska nemocnice Liberec as
- KardioBusak sro
- Kardio Pudich s.r.o.
- Vseobecna intermi ambulance sro
- MUDr Zbynek Kosek, kardiologicka ambulance sro
- Pozdisek sro, Kardiologicka ambulance
- Benedor sro - Kardiologicka, cevni a interni ambulance
- Kardiologicka a angiologicka ambulance
- CCR Ostrava sro
- Mestska nemocnice Ostrava
- Center for Clinical Research Pardubice, sro
- Nemocnice Pardubickeho kraje as
- Kardiologie v sadech sro
- Kardiologie Cor sro
- Ordinace pro choroby srdce a cev
- Diabet2 sro
- Vseobecna fakultni nemocnice v Praze
- CCR Prague sro
- Thomayerova nemocnice
- Milan Kvapil sro
- Kardiologicke centrum MUDr Janky Skrobakove sro
- Fakultni nemocnice v Motole
- Interni a kardiologicka ordinace
- Endokrinologie Cerny Most sro
- Kardio Vaclavik sro, Interni a kardiologicka ambulance
- Vestra Clinics sro
- Nemocnice Pardubickeho kraje as, Svitavska nemocnice
- AeskuLab ks, Lipidova poradna
- Nemocnice Podlesi as
- Clinical Trials Service sro
- Interni ambulance
- Lekarsky dum Ormiga
- KIGE sro
- Aalborg Hospital
- Center for Clinical and Basic Research Aalborg
- Aarhus Universitetshospital
- Centre for Clinical and Basic Research Ballerup
- Sydvestjysk Sygehus
- Sanos Clinic
- Steno Diabetes Center
- Regionhospitalet Herning
- Hillerod Hospital
- Rigshospitalet Kobenhavn
- Amager Hospital
- Kolding Sygehus
- Regionshospitalet Silkeborg
- Svendborg Sygehus
- Center for Clinical and Basic Research Vejle
- Regionshospitalet Viborg
- Liina Viitas OU
- Center for Clinical and Basic Research Tallinn
- Dr Arvo Rosenthal LLC
- North Estonia Medical Centre Foundation
- Helsinki University Central Hospital
- GERI-MED Oy
- Pohjois-Karjalan keskussairaala
- Terveystalo Jyvaskyla
- Studycor Oy
- Satucon Oy/Kuopion tyoterveys
- University of Eastern Finland
- Oulu University Hospital
- Oulu University Hospital
- Tampere University Hospital
- Terveystalo Pulssi
- Centre Hospitalier Universitaire Amiens - Hopital Sud
- Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
- Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre
- Centre Hospitalier Sud Francilien
- Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
- Groupement Hospitalier Mutualiste
- Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
- Centre Hospitalier de Versailles - Hopital Andre Mignot
- Hopital Louis Pasteur
- Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
- Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot
- Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone
- Hopital Saint-Joseph
- Centre Hospitalier Regional Universitaire de Montpellier - Hopital Arnaud de Villeneuve
- Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
- Centre Hospitalier Universitaire de Nice - Hopital Pasteur
- Centre Hospitalier Universitaire de Nimes
- Hopital Saint Antoine
- Hopital Pitie-Salpetriere
- Hopital Europeen Georges Pompidou
- Hopital Bichat Claude Bernard
- Centre Hospitalier de Pau - Hopital Francois Mitterrand
- Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
- Clinique Saint Hilaire
- Clinique Pasteur
- Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
- Polyclinique Vauban
- Universitaets-Herzzentrum Freiburg - Bad Krozingen
- Kerckhoff-Klinik Forschungs GmbH
- Klinische Forschung Berlin GbR
- Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum
- Kardiologisch - Angiologische Praxis - Herzzentrum Bremen
- Sankt-Johannes-Hospital
- Cardiologicum Dresden und Pirna
- Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann
- Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III
- Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main
- Clin Phenomics GmbH Co KG
- Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
- Cardiologicum Hamburg
- Universitätsklinikum Heidelberg
- Ambulantes Herzzentrum Kassel
- Universitätsklinikum Leipzig
- Otto von Guericke Universität Magdeburg
- Johannes Gutenberg Universitaet Mainz
- Universitätsklinikum Mannheim
- Praxis Doktor Jens Taggeselle
- Deutsches Herzzentrum München des Freistaates Bayern
- Herz Gefaess Zentrum Nymphenburg
- Universitaetsklinikum Muenster
- Kardiologische Gemeinschaftspraxis Papenburg
- Klinikum Ernst von Bergmann gGmbH
- Universitätsklinikum Regensburg
- CardioConsil GmbH
- I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz
- Universitätsklinikum Ulm
- Nephrologisches Zentrum Villingen-Schwenningen
- Forschungszentrum Ruhr
- General Hospital of Athens Evaggelismos
- Athens Naval Hospital
- General Hospital of Athens Georgios Gennimatas
- General Hospital of Athens Ippokrateio
- General Hospital of Athens Laiko
- Alexandra Hospital
- Konstantopoulio - Agia Olga Hospital of Nea Ionia
- Hygeia Hospital
- University Hospital of Heraklion
- University Hospital of Ioannina
- University Hospital of Larissa
- Ahepa University Hospital
- General Hospital of Thessaloniki Ahepa
- Papageorgiou General Hospital of Thessaloniki
- Interbalkan Medical Center
- Lausmed Kft
- Allami Szivkorhaz Balatonfured
- Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje
- Med-Edu Bt
- Dr Lakatos Ferenc Private Cardiology Practice
- Grof Tisza Istvan Korhaz
- Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz
- Clinexpert Kft
- Obudai Egeszsegugyi Centrum Kft
- Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
- Gottsegen Gyorgy Orszagos Kardiologiai Intezet
- Bajcsy-Zsilinszky Korhaz es Rendelointezet
- Semmelweis Egyetem
- Magyar Honvedseg Egeszsegugyi Kozpont
- Uzsoki Utcai Korhaz
- Zugloi Egeszsegugyi Szolgalat
- Jahn Ferenc Del-pesti Korhaz es Rendelointezet
- Debreceni Egyetem Klinikai Kozpont
- Markhot Ferenc Oktatokorhaz es Rendelointezet
- Erzsebet Gondozohaz
- Bugat Pal Korhaz
- Pharma4 Trial Kft
- Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
- BKS Research Kft
- Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza
- Selye Janos Korhaz
- Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz
- CRU Hungary Kft
- Pecsi Tudomanyegyetem Klinikai Kozpont
- Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
- Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
- Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
- Praxispont Belvarosi Maganegeszsegugyi Kozpont
- Tolna Megyei Balassa Janos Korhaz
- Csongrad Megyei Dr Bugyi Istvan Korhaz
- Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
- Belvarosi Egeszseghaz Kft
- Hjartamidstodin
- Landspitali
- Ospedale Muscatello
- Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
- Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi
- Azienda Ospedaliero Universitaria Mater Domini
- Universita degli Studi Gabriele D Annunzio di Chieti e Pescara
- Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci
- IRCCS Ospedale San Raffaele
- Centro Cardiologico Monzino
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
- Azienda Ospedaliero Universitaria Pisana
- Presidio Ospedaliero Santa Maria delle Grazie
- Policlinico Universitario Campus Biomedico
- Azienda Ospedaliera Sant Andrea
- IRCCS Policlinico San Donato
- Azienda Ospedaliera Citta della Salute e della Scienza di Torino
- Azienda Ospedaliero Universitaria Integrata di Udine
- Inje University Busan Paik Hospital
- Dong-A University Hospital
- Chungbuk National University Hospital
- Yeungnam University Medical Center
- Keimyung University, Dongsan Hospital
- Chonnam National University Hospital
- Gachon University Gil Medical Center
- Seoul National University Bundang Hospital
- Kyung Hee University Hospital
- Korea University Anam Hospital
- Seoul National University Hospital
- Kangbuk Samsung Hospital
- Severance Hospital, Yonsei University Health System
- Asan Medical Center
- Samsung Medical Center
- The Catholic University of Korea Seoul St Marys Hospital
- Gangnam Severance Hospital
- Ajou University Hospital
- Yonsei University Wonju Severance Christian Hospital
- Daugavpils Regional Hospital
- Dace Teterovska Doctor Practice in Endocrinology
- Inga Jasinkevica Cardiologist Practice
- Pauls Stradins Clinical University Hospital
- Outpatient Clinic Veselibas Centrs 4
- Klinikiniai sprendimai, UAB
- Klinikiniai sprendimai, UAB
- Saules Seimos Medicinos Centras
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
- Kardiologijos ir reabilitacijos klinika, UAB
- Siauliai Republican Hospital, Public Institution
- Vilnius University Hospital Santaros Clinic Public Institution
- Clinstile SA de CV
- Unidad Biomedica Avanzada Monterrey
- Centro de Estudios Clinicos de Queretaro
- Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
- Centro de investigacion Cardiometabolica
- Scientia Investigacion Clinica Sc
- Noordwest Ziekenhuisgroep
- Ziekenhuisgroep Twente
- Emotional Brain
- Meander Medisch Centrum
- Onze Lieve Vrouwe Gasthuis
- Onze Lieve Vrouwe Gasthuis
- Academisch Medisch Centrum
- Gelre Ziekenhuis
- Rijnstate Ziekenhuis
- Rode Kruis Ziekenhuis
- Amphia ziekenhuis
- Reinier de Graaf Gasthuis
- Huisartsenpraktijk Rambharose
- Deventer Ziekenhuis
- Van Weel Bethesda Ziekenhuis
- Albert Schweitzer Ziekenhuis location Dordwijk
- Albert Schweitzer Ziekenhuis, Locatie Dordwijk
- Ziekenhuis Gelderse Vallei
- Catharina Ziekenhuis
- Treant Zorggroep, locatie Scheper ziekenhuis Emmen
- Medisch Spectrum Twente
- Admiraal de Ruyter Ziekenhuis
- Groene Hart Ziekenhuis
- Martini Ziekenhuis
- Sint Jansdal Ziekenhuis
- Zuyderland Medisch Centrum
- Elkerliek Ziekenhuis
- Tergooi
- Bethesda Diabetes Research Center
- Dijklander Ziekenhuis Hoorn
- Medisch Centrum Leeuwarden
- Leids Universitair Medisch Centrum
- Isala Diaconessenhuis
- Sint Antonius Ziekenhuis, locatie Nieuwegein
- Radboudumc
- Canisius-Wilhelmina Ziekenhuis
- Franciscus Gasthuis
- Praktijk Soerland
- Maasstad Ziekenhuis
- Ikazia Ziekenhuis
- Franciscus Vlietland
- D&A Research and Genetics
- Haga Ziekenhuis
- Ziekenhuis Rivierenland
- Elisabeth-Tweesteden Ziekenhuis
- Ziekenhuis Bernhoven
- Diakonessenhuis
- Universitair Medisch Centrum Utrecht
- VieCuri Medisch Centrum
- Zaans Medisch Centrum
- Albert Schweitzer Ziekenhuis
- Dokters van Nederhoven
- Isala Klinieken
- Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy
- American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow
- Uniwersyteckie Centrum Kliniczne
- Copernicus Podmiot Leczniczy Sp zoo
- NZOZ Srodmiescie Spzoo
- Marek Piepiorka Gabinet Kardiologiczno-Internistyczny
- Spolka Cywilna Medicina
- Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II
- Biokinetica SA
- Centrum Medyczne Pratia Katowice
- Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon
- Wojewodzki Szpital Zespolony w Kielcach
- Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
- Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo
- Krakowskie Centrum Medyczne Spzoo
- CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne
- Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie
- Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
- Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
- Instytut Centrum Zdrowia Matki Polki
- Miedziowe Centrum Zdrowia Spolka Akcyjna
- CenterMed Lublin Spzoo
- Clinical Best Solutions Sp zoo Spolka komandytowa Gabinet Lekarski
- Ko-med Centra Kliniczne Lublin II
- NZOZ Twoja Przychodnia Spzoo
- Szpital Swietej Anny w Miechowie
- Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu
- Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ
- NZOZ Specjalistyczna Przychodnia Lekarska Medikard
- Clinical Research Center Spzoo Medic-R Spolka Komandytowa
- KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy
- NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna
- Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa
- ETG Network Spzoo
- KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow
- Tomasz Blicharski Lubelskie Centrum Diagnostyczne
- Indywidualna Specjalistyczna Praktyka Lekarska
- Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna
- Medical Trials Institute Spzoo
- Prywatne Centrum Kardiologii
- Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu
- Centrum Medyczne Amed Warszawa Zoliborz
- Centrum Medyczne Pratia Warszawa
- Clinical Best Solutions Sp zoo Spolka komandytowa
- Instytut Psychiatrii i Neurologii
- Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie
- Medicor Plus Kardiolodzy Spzoo
- Futuremeds spolka z ograniczona odpowiedzialnoscia
- Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw
- Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska
- KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc
- Hospital Garcia de Orta, EPE
- Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro
- Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz
- Centro Hospitalar e Universitario de Coimbra EPE
- Hospital de Faro, EPE
- Hospital da Senhora da Oliveira, Guimaraes, EPE
- Associacao Protectora dos Diabeticos de Portugal
- Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano
- Hospital Casa de Saude Sao Mateus
- SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L
- Spitalul Universitar de Urgenta Bucuresti
- Spitalul Clinic Universitar de Urgenta Elias
- Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",
- Cardiomed SRL
- Consultmed SRL
- SC Cardiomed SRL
- SC Endodigest SRL
- SC Sal Med SRL
- Mediab SRL
- CMI Dr Podoleanu Cristian
- First City Clinical Hospital na E E Volosevich
- NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways
- Regional State Budget Health care Institution Altay Regional Cardiology Dispensary
- Central City Clinical Hospital 1 of the Oktyabrsky District
- State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1
- Regional Budget Healthcare Institution Cardiology Dispensary
- BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya
- FSBI Heart and Vessels Diseases complex problems Scientific Research Institution
- Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1
- Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region
- SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky
- National Medical Research Center for therapy and preventive medicine
- Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department
- SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department
- City Clinical Hospital named after Zhadkevich
- FSBI Russian Cardiology Research and Production Complex
- SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko
- LLC RC Medical
- SBHI of Novosibirsk Region City clinical hospital 1
- FSBSI Scientific Research Institute of Therapy and preventive medicine
- Budget Healthcare Institution of Omsk region Medical-sanitary unit 9
- Perm Regional Hospital for War Veterans
- State Budget Institution of Ryazan Region Regional Clinical Hospital
- SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg
- Almazov National Medical Research Centre
- Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
- Saint Petersburg State Budget Healthcare Institution City Polyclinic 109
- City polyclinic 25 Nevsky district
- Saint Petersburg SBHI City Hospital 38 named after N A Semashko
- Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital
- LLC Mart
- LLC Medinef Clinic
- Samara Regional Clinical Cardiology Dispensary
- Clinical Hospital named after S R Mirotvortsev
- Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital
- State Budgetary Health Institution City Hospital 4 of the City of Sochi
- City Polyclinic 27
- FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences
- Tyumen State Medical University
- State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center
- SBHI of Vladimirskaya region City Hospital 4 of Vladimir
- Family Medicine Clinic
- Alian, sro
- MediTask, sro
- Narodny ustav srdcovych a cievnych chorob, as
- Veria, sro
- Nemocnica s poliklinikou Brezno, no
- Medical group Kosice sro
- Cardio D and R, sro Kosice
- Kardio 1 sro
- Medi M and M sro
- Oralek, sro
- Kardiocentrum Nitra sro
- Kardiomed NZ, sro
- Medikard, sro
- Medispol, sro
- Diab sro
- Mediluk sro
- Interna SK, sro
- Areteus sro
- CardiOr, sro
- Hospital Virgen del Mar
- Hospital Universitario Reina Sofia
- Hospital Universitario Virgen de las Nieves
- Hospital Clinico Universitario Virgen de la Victoria
- Hospital Universitario Virgen Macarena
- Hospital Universitario Miguel Servet
- Hospital Universitario de Gran Canaria Doctor Negrin
- Hospital Clinico Universitario de Valladolid
- Hospital Universitari Germans Trias i Pujol
- Equip Atencio Primaria Sardenya
- Hospital Clinic i Provincial de Barcelona
- Hospital Universitari Sant Joan de Reus
- Hospital Universitari i Politecnic La Fe
- Hospital Clinico Universitario de Valencia
- Complexo Hospitalario Universitario A Coruña
- Hospital Clinico Universitario de Santiago
- Hospital Alvaro Cunqueiro
- Hospital Universitario Virgen de la Arrixaca
- Complejo Hospitalario de Navarra
- Hospital Universitario de La Princesa
- Fundacion Jimenez Diaz
- Hospital Clinico San Carlos
- Hospital Universitario 12 de Octubre
- Hospital Universitario La Paz
- Hospital Universitario Infanta Sofia
- Sodra Alvsborgs sjukhus
- Falu Lasarett
- Carlanderska
- Sahlgrenska Universitetssjukhus
- Obackakliniken i Harnosand
- PharmaSite Helsingborg
- Lanssjukhuset Ryhov
- Centralsjukhuset Karlstad
- Skaraborgs sjukhus Lidkoping
- Clemenstorgets Hjartmottagning
- PharmaSite Malmo
- Ostersunds sjukhus
- Akardo MedSite
- Norrlands Universitetssjukhus
- Hallands sjukhus Varberg
- Hualien Tzu Chi Hospital
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- Kaohsiung Chang Gung Memorial Hospital
- Mackay Memorial Hospital Tamsui Branch
- Chung Shan Medical University Hospital
- Taichung Veterans General Hospital
- National Cheng Kung University Hospital
- National Taiwan University Hospital
- Taipei Veterans General Hospital
- Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
- Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council
- Communal Healthcare Institution Kharkiv City Clinical Hospital No27
- Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant
- Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council
- Oleksandrivska Clinical Hospital of Kyiv
- Kyiv City Clinical Hospital 1
- Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi
- Kyiv City Clinical Emergency Medical Care Hospital
- National Scientific Center "M.D. Strazhesko Institute of Cardiology"
- State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr
- State Institution National Scientific Center Acad Strazhesko Institute of Cardiology
- Medical Centre CONSILIUM Medical
- Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery
- Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University
- Private Small Enterprise, Medical Center Pulse
- Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council
- Aberdeen Royal Infirmary
- Barnsley Hospital
- Royal United Hospital
- Royal Victoria Hospital
- Ulster Hospital
- Ormeau Health Centre
- Bollington Medical Centre
- Royal Bournemouth Hospital
- West Walk Surgery
- University Hospitals of Derby and Burton NHS Foundation Trust
- Ashgate Medical Practice
- Cleveleys Group Practice
- Lakeside Healthcare
- Medinova Northamptonshire Dedicated Research Site
- MeDiNova Warwickshire Quality Research Site
- Pound Hill Medical Group
- Ninewells Hospital
- Glasgow Royal Infirmary
- Hull Royal Infirmary
- Highlands Clinical Research Facility, Raigmore Hospital
- Sherbourne Medical Centre
- Royal Liverpool University Hospital
- Barts Health NHS Trust
- Royal Free London NHS Foundation Trust
- Guys Hospital
- Wythenshawe Hospital
- Medinova North London Dedicated Research Centre
- Nottingham City Hospital
- George Eliot Hospital
- Medinova South London Dedicated Research Centre
- Mounts Bay Medical Hub
- The Health Centre Yaxley
- The Adam Practice
- Medinova East London Dedicated Research Centre
- Ashfield Primary Care Centre
- Scunthorpe General Hospital
- Medinova Limited
- Eaton Socon Health Centre
- Lakeside Healthcare Stamford
- Lister Hospital
- Singleton Hospital
- The Breckland Alliance
- Torbay Hospital
- Pinderfields Hospital
- Sheepcot Medical Practice
- Sandwell General Hospital
- Whitby Group Practice
- MeDiNova West London Quality Research Site
- Worcestershire Royal Hospital
- Yeovil District Hospital
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Experimental
Placebo
Evolocumab 140 mg Q2W
Participants will receive placebo subcutaneous injection once every 2 weeks (Q2W).
Participants will receive 140 mg evolocumab by subcutaneous injection Q2W.