Prediction for Coma Recovery With Comaweb (COMASCORE)
Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI)
About this trial
This is an interventional other trial for Brain Injury, Coma focused on measuring Outcome prediction, Disorders of Consciousness, Coma,, MRI, Brain injury
Eligibility Criteria
Patient Inclusion criteria
- Male or female subject of 18 years old or above
- Affiliated to a social security system excluding "Aide Médicale d'État (AME)"
- Hospitalized in an intensive care unit and requiring mechanical ventilation after TBI, aSAH or CA
- Absence of response to simple orders not explained by sedation alone at inclusion
- Patient within 7 to 45 days after onset of TBI, aSAH or CA
- Scheduled MRI within 5 days after inclusion
- Written informed consent to participate in the study must be obtained proxy/legal representative.
Patient non-inclusion criteria
- MRI unavailability between day 7 and day 45 after brain injury
- Origin of coma other than CA, TBI or aSAH
- Pre-existing serious brain disease prior to coma status
- Contra-indication to perform MRI
- Subject protected by the law (curatorship or tutorship)
Patient secondary exclusion criteria
- Consciousness recovery before MRI exam
- Contra-indication to perform MRI (appeared / discovered after inclusion)
Healthy controls Inclusion criteria
- Male or female subject from 18 to 65 years
- Affiliated to a social security system excluding "Aide Médicale d'État (AME)".
- No history of previous brain disease
- No contra-indication to perform an MRI.
- No pregnancy
- Voluntarily agrees to participate by providing written informed consent
Healthy controls Non-Inclusion criteria
1. Subject protected by the law (curatorship or tutorship)"
Sites / Locations
- Centre Hospitalier Saint-JeanRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Patient group
Test group
To assess the predictive accuracy of comaScore evaluated in the day 7 - day 45 period post brain injury to predict unfavorable outcome at 1-year after the first insult in patients admitted in ICU after CA, TBI and aSAH, that remain comatose at least 7 days after brain injury.
MRI calibration in each center : test protocol compliance, data transfer procedures and quality of the MRI sequences