Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat
About this trial
This is an interventional treatment trial for Non-Alcoholic Fatty Liver Disease focused on measuring MRI, Dietitian Lifestyle intervention, Bariatric surgery, Brown adipose tissue, White adipose tissue, no alcoholic fatty liver disease, diabetes mellitus type 2, Pancreatic fat
Eligibility Criteria
Inclusion Criteria:
- BMI ≥ 25-30 kg/m2
- BMI ≥ 30 kg/m2 with Metabolic syndrome
- BMI ≥ 35 kg/m2 for morbid obesity
Exclusion Criteria:
- Other kind of hepatic diseases
- Under medications known to affect liver fat
- Waist circumference ≥ 150 cm
- Weight ≥ 250 kg
- MRI contraindications
Sites / Locations
- The Chinese University of Hong Kong, Prince of Wale HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Morbid obesity- Bariatric surgery group
Morbid obesity-Dietitian led life style intervention group
Mild obesity-Dietitian led life style intervention group
Mild obesity-Conventional care group (control)
Morbid obese subjects who will consent to bariatric surgery
Morbid obese subjects who will not consent to bariatric surgery but instead opt for dietitian led life style intervention
Mild- Moderate subjects assigned through a randomized controlled trial to the dietitian led life style intervention
Mild- Moderate subjects assigned through a randomized controlled trial to conventional care