The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
About this trial
This is an interventional treatment trial for Polycystic Ovary Syndrome
Eligibility Criteria
Inclusion Criteria:
- Infertile women with polycystic ovary syndrome based on Rotterdam criterion
- 20<Age<38
- BMI<30
- Non recurrent miscarriage
- Non endocrine, hematologic and autoimmune disorders
- Non chromosomal and genetic abnormalities
- Non uterine anomalies, surgical history, endometriosis, adenomyosis, hydrosalpinx, uterine fibroids
- Non azoospermia
Exclusion Criteria:
1. Patient's tendency for withdrawal
Sites / Locations
- Royan Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
No Intervention
No Intervention
Minimal ovarian stimulation with rec-FSH
Minimal ovarian stimulation with HMG
Mild ovarian stimulation with rec-FSH
Mild ovarian stimulation with HMG
The group of minimal ovarian stimulation that will receive 100 mg clomiphene citrate every day from Day 3 to Day 7 of the menstrual cycle and then will be treated with 150 International Unit (IU) Gonal-f (Follitropin alfa, Merck Serono, Germany) after the seventh day.
The group of minimal ovarian stimulation that will receive 100 mg clomiphene citrate every day from Day 3 to Day 7 of the menstrual cycle and then will be treated with 150 IU Merional (Highly Purified Menotropin، IBSA، Switzerland) after the seventh day.
The group of mild ovarian stimulation that will receive 150 IU Gonal-f (Follitropin alfa, Merck Serono, Germany) daily from Day 3 of the menstrual cycle.
The group of mild ovarian stimulation that will receive 150 IU Merional (Highly Purified Menotropin، IBSA، Switzerland) daily from Day 3 of the menstrual cycle.