Innervation of Vascularized Iliac Transplant Avoids Resorption in Jaw Bone Reconstruction (INVITATION)
Bone Resorption, Nerve
About this trial
This is an interventional treatment trial for Bone Resorption focused on measuring Jaw reconstruction, Innervation, Bone resorption
Eligibility Criteria
Inclusion Criteria:
- Patients between the age of 17 to 65 years (to avoid possible postmenopause osteoporosis), irrespective of gender.
- Post resection segmental defect of mandible between 5-9 cm long.
- Acceptable systemic conditions like nonmenopausal-related osteoporosis, Diabetes mellitus, in controlled normal range.
- Patients agreeing to sign the informed consent form.
Exclusion Criteria:
- Advanced malignant tumors.
- Poor general condition, who can not tolerate vascularized bone flap reconstruction.
- History of drugs affecting bone metabolism, like bisphosphonates, calcium agents or others.
Sites / Locations
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRecruiting
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Innervation
Non-innervation
Patients with segmental defects of mandible sized 5 to 12 cm long will be reconstructed using microsurgical iliac or fibula bone flaps. In simultaneous innervated group, neurorrhaphy between the ilioinguinal nerve or fibula flap nerve with inferior alveolar nerve or great auricular nerve will be performed. Intervention: Procedure: Innervation
Patients with segmental defects of mandible sized 5 to 12 cm long will be reconstructed using microsurgical iliac or fibular bone flaps. In traditional noninnervated group, neurorrhaphy will not be performed. Intervention: Procedure: Non-innervation