Treating Persistent Post-concussion Symptoms With Exercise
Brain Injuries, Traumatic, Concussion, Brain, Mild Traumatic Brain Injury
About this trial
This is an interventional treatment trial for Brain Injuries, Traumatic
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of mild traumatic brain injury (mTBI) based on the American Congress of Rehabilitation Medicine (ACRM) criteria.
- mTBI occurrence from 3 months to 5 years from study start date
- Diagnosis of persistent post-concussion symptoms based on the ICD-10 criteria.
- Cleared for physical activity based on The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) by treating physician
- at low risk for cardiopulmonary disease in accordance with the American College of Sports Medicine guidelines
- exercise intolerance (inability to exercise at pre-injury intensity/duration due to acute presentation of symptoms)
Exclusion Criteria:
- past medical history of neurological disorders (i.e., Parkinson's disease, neuromuscular disorders)
- contraindications to MRI
- cardiopulmonary disorder
- chronic musculoskeletal condition
- psychiatric disorder other than depression and/or anxiety (i.e., schizophrenia, bipolar disorder)
- cancer
- pregnancy
Sites / Locations
- University Of Calgary
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Aerobic Exercise Protocol (AEP)
Stretching Protocol (SP)
Symptom threshold will be determined at baseline and repeated every 3 weeks using the Buffalo Concussion Treadmill Test. Briefly, there will be an initial 4min warm up at 1.7mph. The protocol will start with treadmill speed se to 3.3 mph and 0.0% incline. Each subsequent minute, the incline will increase by 1.0% to a max of 15%. At 15% grade, if the participant is still able to continue, treadmill speed will increase by 0.4mph each minute. Heart rate (HR) and rating of perceived excretion (RPE Borg scale) will be measured every minute. The test will be terminated upon symptom exacerbation at which time HR and RPE will be recorded. Every 3 weeks the symptom threshold test will be repeated for all participants and exercise prescription will be adjusted accordingly.
The exercise testing for the stretching protocol to determine exercise prescription will be the same as described above.