Remote Ischemic Conditioning in Traumatic Brain Injury (MOTION)
Traumatic Brain Injury, Brain Injuries, Brain Trauma
About this trial
This is an interventional treatment trial for Traumatic Brain Injury focused on measuring Remote Ischemic Conditioning, Traumatic Brain Injury
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 17years.
- Diagnosis of traumatic brain injury.
- Glasgow Coma Scale (GCS) ≤13
- Intra-cranial hemorrhage (ICH) on initial brain CT scan
Exclusion Criteria:
- Patients with traumatic brain injury >24 hours
- Transferred from other centers
- Declined to participate in the study
Sites / Locations
- Banner University Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Remote Ischemic Conditioning
No Remote Ischemic Conditioning
Remote ischemic conditioning will be performed using a standard manual blood pressure cuff. The pressure in the blood pressure cuff will be maintained at 30 mm of Hg higher than the patient's systolic blood pressure. 4 cycles of ischemic conditioning will be performed each day for a period of 7 days. Each cycle consists of 5 min of controlled upper limb ischemia (cuff up) followed by 5 min of reperfusion (cuff down). The total duration of the treatment cycle will be 40 min. The study protocol is based on our published literature in traumatic brain injury. Blood samples will be collected at 0 hours (before randomization). Then the first 4 cycles of RIC (done consecutively) will be performed, blood samples will be taken at 6 hours post randomization and then at 24 hours post randomization. RIC cycles will then be performed on a daily basis followed by taking a blood sample once daily during the patients' length of stay up to a maximum of 7 days
Blood samples will be collected at 0 hours (before randomization). Blood samples will then be collected at 6 hours post randomization and 24 hours post randomization. These patients will not receive daily RIC therapy but will only have their blood drawn once daily during the patients' length of stay up to a maximum of 7 days.