Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
Mechanical Ventilation Complication
About this trial
This is an interventional treatment trial for Mechanical Ventilation Complication focused on measuring Diaphragm Atrophy, Ventilator Induced Diaphragm Dysfunction, Mechanical Ventilation, Volume Support Mode, Assist Control Mode, Diaphragm Thickening Fraction, Intubation, Delirium, Ventilator-Free Days
Eligibility Criteria
Inclusion Criteria:
subjects > 18 years of age that have been intubated and mechanically ventilated for < 36 hours at the time of screening will be eligible for enrollment
Exclusion Criteria:
- pregnancy
- cardiopulmonary arrest
- history of diaphragmatic paralysis or neuromuscular disease
- chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation
- neuromuscular blockade
- expectation to be liberated from ventilator in < 24 hours
- history of mechanical ventilation in the last 6 months
- presence of tracheostomy
- high cervical spine injury
Sites / Locations
- The University of Chicago Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Volume Support Mode Mechanical Ventilation
Assist Control Mode Mechanical Ventilation
Volume support mode ventilation is a spontaneous mode where a target goal volume is set on the ventilator. This ventilatory strategy is dependent on patients spontaneously breathing and triggering (or activating) the ventilator to support the breath. The ventilator adjusts the amount of pressure support to deliver with each breath (i.e. if the patient's tidal volume is greater than the set target volume, then the ventilator will decrease the amount of pressure support in the subsequent breath to try to achieve the goal volume and vice versa). The respiratory rate is not set in this mode of ventilation and is dependent on the patient. For patients randomized to this mode, the goal tidal volume will be set at 6 cc/kg of ideal body weight (IBW).
In assist control mode ventilation, the machine is programmed to deliver a set tidal volume and set respiratory rate. Patients can breathe over the set respiratory rate, but the volume of breath that they receive is fixed and delivered by the ventilator. For patients randomized to this mode, the tidal volume will be set at 6 cc/kg of ideal body weight (IBW).