Does Higher (100% Oxygen) Versus Lower (21% Oxygen) During CC+SI During CPR of Asphyxiated Newborns Improve Time to ROSC (SURV1VE-O2)
Heart; Arrest, Newborn, Birth Asphyxia, Bradycardia Neonatal
About this trial
This is an interventional treatment trial for Heart; Arrest, Newborn focused on measuring Chest Compression, Newborn, Infant, Sustained Inflation
Eligibility Criteria
Inclusion Criteria:
- Term infants requiring chest compressions in the delivery room
- Preterm infants >28 weeks' gestation requiring chest compressions in the delivery room
Exclusion Criteria:
- Infants with congenital abnormality
- Infants with congenital diaphragmatic hernia or congenital heart disease
- Infants who's parents refused to give consent to this study
Sites / Locations
- Royal Alexandra Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention (21% oxygen during CC+SI)
Intervention (100% oxygen during CC+SI)
Infants randomized into the "21% oxygen CC+SI group" will receive a SI with a PIP of 25-30 cmH2O while receiving chest compression. The SI will be delivered over a period of 20 seconds. This will be followed by PEEP of 5-8 cm water fro 1sec. The use of 20sec SI will be repeated 3 times, which results to 60sec of chest compression. At that time the clinical team will perform an assessment of the newborn's heart rate. If heart rate is >60/min continue with standard care as per local hospital policy (standard hospital practice guideline). If heart rate remains <60/min continue with CC+SI for another 20sec at which time a further assessment should be performed. If heart rate remains <60/min continue with CC+SI. During CC+SI the clinical team will only use 21% oxygen.
Infants randomized into the "100% oxygen CC+SI group" will receive a SI with a PIP of 25-30 cmH2O while receiving chest compression. The SI will be delivered over a period of 20 seconds. This will be followed by PEEP of 5-8 cm water fro 1sec. The use of 20sec SI will be repeated 3 times, which results to 60sec of chest compression. At that time the clinical team will perform an assessment of the newborn's heart rate. If heart rate is >60/min continue with standard care as per local hospital policy (standard hospital practice guideline). If heart rate remains <60/min continue with CC+SI for another 20sec at which time a further assessment should be performed. If heart rate remains <60/min continue with CC+SI. During CC+SI the clinical team will only use 100% oxygen.