Liposomal Bupivacaine After Cesarean Delivery
Pain, Postoperative, Opioid Use
About this trial
This is an interventional treatment trial for Pain, Postoperative
Eligibility Criteria
Inclusion Criteria:
- Are between 18 and 45 years of age, inclusive.
- Are undergoing a planned, primary or repeat, cesarean delivery without permanent sterilization.
- Have a BMI ≤ 60.
- Are able to read and understand English.
Exclusion Criteria:
- Have pre-eclampsia with severe features.
- Has been taking medication assisted treatment for opioid addiction during this pregnancy.
- Have known sensitivity to local anesthetic.
- Have a known sensitivity to non-steroidal anti-inflammatory medications.
- Planning to have a tubal ligation after the cesarean delivery.
- Are unable to receive neuraxial analgesia and/or Duramorph, a morphine formulation that is the standard of care for intrathecal anesthesia at MVH.
- Are prisoners.
Sites / Locations
- Miami Valley Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
liposomal bupivacaine infiltration
Saline infiltration
Local infiltration of all wound layers with liposomal bupivacaine (Exparel(R)) 20 ml diluted with 70 ml of normal saline to 90 ml for patient with a BMI of 39 and under. If BMI is 40 or more the 20 ml of liposomal bupivicaine will be diluted to 150 ml by adding 130 ml of normal saline
Local infiltration of all wound layers with saline, using to match the amount. The amount of total fluid is divided into 4 and instilled with 1-2 ml at a time in between fascial layers after fascial closure. Each 1/4 will be instilled laterally (2) and on each side of the incision(2)- extra fluid is placed subcutaneously.