Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases
Cardiopulmonary Disease
About this trial
This is an interventional other trial for Cardiopulmonary Disease
Eligibility Criteria
Inclusion criteria:
- Healthy controls (no known cardiac or pulmonary disease);
- PAH/HFpEF patients with known RV failure;
- PAH/HFpEF patients with known pulmonary failure
- Newly diagnosed PAH/HFpEF patients without any evidence of profound RV or pulmonary dysfunction.
Exclusion criteria:
- Persons unable to perform light exercise
- Persons pregnant or planning to be pregnant
Sites / Locations
- Mayo Clinic in RochesterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Non-invasive assesment techniques
Efficacy of acute-oxygen therapy during exercise
We hypothesize that non-invasive indices of right ventricular RV (echocardiograph-derived strain and strain rate) and pulmonary (gas exchange-derived lung diffusion and surface area) function during light exercise will successfully identify and discern patients with known RV dysfunction pulmonary arterial hypertension and heart failure with preserved ejection fraction(PAH/HFpEF with RV failure) from those with known pulmonary dysfunction (PAH/HFpEF with pulmonary fibrosis). Additionally, we hypothesize that our assessment techniques will identify subtle derangements in RV and pulmonary function in newly diagnosed PAH and HFpEF patients, and that this may guide early and targeted therapeutic intervention.
We hypothesize that breathing hyperoxia will increase exercise capacity by reversing RV and pulmonary derangements, and that the mechanisms of action will be related to the underlying dysfunction (e.g., reducing pulse volume recording PVR, increasing RV functional reserve, increasing gas diffusion).