Neurostimulation and OCD, a MRI Study (ASLTOC)
Obsessive Compulsive Disorder
About this trial
This is an interventional other trial for Obsessive Compulsive Disorder focused on measuring Arterial Spin Labeling, Obsessive Compulsive Disorder, Magnetic Resonance Imaging, Repetitive Transcranial Magnetic Stimulation, Double blinded, Sham
Eligibility Criteria
Inclusion Criteria:
- Participants over 18 to 65
- Score at YBOCS over 15
- Diagnosis of Obsessive Compulsive Disorder acknowledged by two psychiatrists using the DSM V criteria
- Patient is able to receive and understand information about the trial, and agrees to participate in the trial
- Indication of treatment by rTMS
Exclusion Criteria:
Related to MRI and / or rTMS:
- Cardiac Stimulator or Implantable Automatic Defibrillator
- Neurosurgical Clips
- Cochlear Implant
- Intra ocular or cranial metallic foreign body
- Endoprosthesis lasting from less than four weeks
- Ostheosynthesis material lasting from less than six weeks
- Claustrophobia
Other criteria:
- Pregnancy or breast feeding
- Unstable hemodynamics, acute respiratory failure, need for constant surveillance not possible during the MRI, precarious general condition
- Patient over legal protection, care without consent
- Active psychiatric pathology other than anxious or mood disorder
- Active severe somatic disease
- History of seizures or other neurologic pathologies (Parkinson's Disease, CVA, Alzheimer's Disease, Multiple Sclerosis, Lewy Body Dementia...)
- Patient without social security
Sites / Locations
- Centre Hospitalier Guillaume Régnier
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
Sham rTMS
Active rTMS
The investigators will perform sham rTMS at 30% of the Motor Threshold, with a 1Hz frequency and 1200 pulses during one session. The target will be the right Orbito Frontal Cortex, localized using Neuronavigation. Sessions will last fifteen minutes; subjects will perform two sessions a day during five days. The coil will have a 180° rotation compared to the active coil position, thus making the magnetic field ineffective on the patient's cortex. Participants will undergo a MRI with anatomical and ASL sequences one week before and four weeks after treatment. All participants of this group will have the opportunity to undergo an active rTMS treatment right after the end of each one's participation in the study.
The investigators will perform active rTMS at 120% of the Motor Threshold, with a 1Hz frequency and 1200 pulses during one session. The target will be the right Orbito Frontal Cortex, localized using Neuronavigation. Sessions will last fifteen minutes; subjects will perform two sessions a day during five days. Participants will undergo a MRI with anatomical and ASL sequences one week before and four weeks after treatment