Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Hypertrophic Scar
About this trial
This is an interventional treatment trial for Hypertrophic Scar focused on measuring platelet rich plasma (PRP), hypertrophic scar, burn scar, tissue repair, vancouver scar scale (VSS), patient and observer scar assessment scale (POSAS)
Eligibility Criteria
Inclusion Criteria:
- Hypertrophic burn scar present on trunk or abdomen
Exclusion Criteria:
- Initial burn injury less than 1 year old
- History of chemical or electrical burn
- Genetic or acquired conditions that severely affect systemic wound healing or collagen formation (vasculitis, diabetes, Ehlers-Danlos syndrome, radiation therapy to the scar site or use of immunosuppressive medications within the last year, active cancer)
Sites / Locations
- Vanderbilt University Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
PRP injection right half
PRP injection left half
The scar to be treated will first be wiped with an alcohol swab, then measured and marked out with a marking pen such that the entirety of the scar will fit into a symmetric ellipse that is drawn, and the ellipse is filled entirely with the scar tissue. A ruler will be used to measure the scar in its greatest horizontal span, and the midway point will be marked with a vertical line. A coin flip will determine if the PRP injection (the experimental half) will be on the right half of the scar (as opposed to the left half). The half of the scar that will not receive PRP will be the control half. After finishing the VSS and POSAS, the area inside the control half of the ellipse will then be subdivided with a marking pen into 1cm x 1cm square boxes, with the plan of injecting 1mL normal saline into each 1 square cm box at 0 months, 1 month, 4 months, and 6 months. Punch biopsies from each scar will be will be obtained at both six months and one year from enrollment.
The scar to be treated will first be wiped with an alcohol swab, then measured and marked out with a marking pen such that the entirety of the scar will fit into a symmetric ellipse that is drawn, and the ellipse is filled entirely with the scar tissue. A ruler will be used to measure the scar in its greatest horizontal span, and the midway point will be marked with a vertical line. A coin flip will determine if the PRP injection (the experimental half) will be on the right half of the scar (as opposed to the left half). The half of the scar that will not receive PRP will be the control half. After finishing the VSS and POSAS, the area inside the experimental half of the ellipse will then be subdivided with a marking pen into 1cm x 1cm square boxes, with the plan of injecting 1mL PRP into each 1 square cm box at 0 months, 1 month, 4 months, and 6 months. Punch biopsies from each scar will be will be obtained at both six months and one year from enrollment.