Functional Electrical Stimulation Cycling for Managing Mobility Disability in People With Multiple Sclerosis
Multiple Sclerosis
About this trial
This is an interventional treatment trial for Multiple Sclerosis focused on measuring exercise, multiple sclerosis, mobility
Eligibility Criteria
Inclusion Criteria:
- diagnosis of multiple sclerosis
- relapse free in the past 30 days
- stable course of disease-modifying therapies over the past 6 months
- ability to communicate in English
- willing to come to the University of Ottawa to complete testing and training sessions
- EDSS score 5.0 - 7.0
- asymptomatic based on a physical activity pre-participation screening tool
Exclusion Criteria:
- presence of any contraindication to FES including epilepsy, a pacemaker, implanted defibrillator, unstable fracture, or pregnancy
- diagnosis of other neurological condition(s)
- participation in FES cycling exercise or other mobility-based exercise rehabilitation program within the past 6 months
- current use of dalfampridine within the past month
Sites / Locations
- University of OttawaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
FES Cycling Exercise
Passive Leg Cycling
FES cycling will involve systematic, transcutaneous electrical stimulation of the leg muscles to produce leg-cycling movement. The intensity and duration of training will be prescribed based on guidelines for aerobic exercise training for persons with MS and from the American College of Sports Medicine, and will progressively increase across 24 weeks. Participants will be encouraged to actively cycle at a minimum cadence of ~40-50 rpm, at 40-60% VO2peak for between 10-50 minutes. The intensity of stimulation will be adjusted per leg muscle group based on sensory tolerance with the goal of maintaining pedaling action and target heart rate over the entire session. At each session, we will record the distance traveled, energy expended, power output, resistance, heart rate and rating of perceived exertion (RPE).
Passive leg cycling will involve movement of the participant's legs by the cycle ergometer motor without electrical stimulation. The duration of training will follow the same schedule as the FES cycling condition and the same data will be recorded at each session. The passive cycling condition will include the same exposure with the training facility, the exercise equipment (i.e. RT300 cycles), and the research staff (i.e. social contact and attention) as with the FES cycling condition.