Combined TMS and Brief Cognitive Behavioral Therapy to Reduce Suicide
Suicide
About this trial
This is an interventional treatment trial for Suicide focused on measuring suicide prevention, Veterans
Eligibility Criteria
Inclusion Criteria:
-Suicide attempt or suicidal ideation with intent to make a suicide attempt within 48 hours of hospitalization as indicated on the hospital chart and confirmed by administration of the C-SSRS.
Exclusion Criteria:
- Primary psychotic disorder
- Bipolar disorder
- Cognitive impairment which would interfere with adequate participation in the project (MMSE < 20).
For safety, participants must meet established screening criteria safety during MRI, which is implemented as a conservative measure given the application of TMS in this population, since MRI involves magnetic fields at similar intensity to those emitted from the stimulation coil. These measures require a patient not having the following (unless MRI-safe):
- Cardiac pacemaker
- Implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord.
TMS-specific exclusions are:
- pregnancy/lactation, or planning to become pregnant during the study
- lifetime history of moderate or severe traumatic brain injury (TBI)
- Current unstable medical conditions
- Current (or past if appropriate) significant neurological disorder
- Lifetime history seizure disorder
- Primary or secondary CNS tumors
- Stroke
- Cerebral aneurysm.
- Other exclusions are conditions that would like to be worsened by TMS, such as bipolar disorder
- Place Veterans at greater risk of seizures from TMS, such as severe and uncontrolled substance use disorder
- Inability to participate in CBT
- Other conditions or circumstance that, in the opinion of the investigator team, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments
Sites / Locations
- Providence VA Medical Center, Providence, RIRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
TMS + Brief Cognitive Behavioral Therapy
Sham TMS + Brief cognitive behavioral therapy
Combined transcranial magnetic stimulation and brief cognitive behavioral therapy for suicide
Sham Transcranial magnetic stimulation and brief cognitive behavioral therapy for suicide