L-Carnitine as an Adjuvant Treatment in Acute Phosphide Poisoning (LC)
Toxicity
About this trial
This is an interventional treatment trial for Toxicity focused on measuring phosphide; poisoning; L-carnitine; oxidative stress
Eligibility Criteria
Inclusion Criteria:
- Patients (male or female, aged 12 years or older) with symptomatic acute phosphide poisoning (deliberate or accidental), with diagnosis made on the basis of:
The typical clinical manifestations due to and following shortly after a single exposure to phosphide.
Reliable identification of the compound based on the container brought by patient attendants or a subsequent confirmation by silver nitrate test for phosphine detection in stomach contents.
Exclusion Criteria:
- Patients less than 12 years of age Pregnant and lactating women Patients with ingestion or exposure to other substances in addition to phosphide.
Patients with other major medical conditions (e.g. cardiovascular disease, renal or hepatic failure).
Patients presenting more than 6 hours of having consumed the phosphide compound (late presenters).
Patients treated for acute phosphide poisoning in any medical center before admission
Sites / Locations
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Non L-Carnitine
L-Carnitine
Subjects in this arm will receive standard treatment only (without LC). It consists of patient resuscitation, gastric decontamination (with sodium bicarbonate, and activated charcoal [1 g/Kg, orally] in the first 6 hours after onset of poisoning), adequate hydration and supportive treatment
Subjects in this arm will receive standard treatment in addition to LC IV, as a dose of 1 g/8 hours