Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis (AFT)
Colorectal Cancer
About this trial
This is an interventional prevention trial for Colorectal Cancer
Eligibility Criteria
Inclusion Criteria:
- Adults (greater than 21 years old)
- Have had advanced tubular adenoma within the last year
Exclusion Criteria:
- Asian ethnicity (Due to common polymorphisms of enzymes involved in alcohol metabolism)
- Does not drink alcohol
- Alcohol use disorder/Alcohol Abuse
- A known genetic predisposition to colorectal cancer (FAP, Lynch syndrome)
- A history of colorectal cancer or inflammatory bowel diseases
Presence of comorbidities that might affect the circadian system
- Chronic renal failure
- Cirrhosis
- Advanced neurological conditions (e.g., Parkinson's, MS, epilepsy)
- Psychological disorders (e.g., PTSD, major depression)
- Sleep apnea
- Restless Leg Syndrome
- Inpatient Status
- Advanced cardiac failure
- Night shift workers with active shift work in the past month
- Planned shift work that will occur during the study
- Crossed more than two time zones in the previous week
- Conditions that alter or necessitate a particular eating pattern (e.g., uncontrolled diabetes, eating disorders)
- Conditions that alter the microbiota (infection or recent history of antibiotic use within three months, or use of pro/prebiotics within one month prior to recruitment)
- Regular use of medications that can potentially affect melatonin profiles (e.g., Melatonin, Metoclopramide, Psychotropic medications, Hypnotics during the four weeks prior to the study)
- Any active cancer
- Inability to sign an informed consent
Sites / Locations
- Rush University Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
"Right-time eating" / no alcohol
"Right-time eating" / with alcohol
"Delayed-eating" / no alcohol
"Delayed-eating" / with alcohol
"Right-time eating" means breakfast before 8am, lunch before 1 pm and dinner before 6pm. Subjects will be asked to stick to this eating schedule for 1 week. Subjects will be asked to not drink alcohol for 1 week. Subjects will randomly be assigned to each eating pattern during the study period.
"Right-time eating" means breakfast before 8am, lunch before 1 pm and dinner before 6pm. Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Moderate alcohol drinking means 0.3-0.5 g/kg alcohol daily, which will be not more than 2 glasses of wine depending on subject's weight. Alcohol will always be consumed in the evening with food or after food (e.g., dinner). The timing of alcohol consumption will be consistent for each individual. Subjects will be provided with red wine for the 1 alcohol intervention week. The order of conditions will be random.
"Delayed-eating" means eating each meal 3 hours later than the "Right-time eating."Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Subjects will be asked to not drink alcohol for 1 week.
"Delayed-eating" means eating each meal 3 hours later than the "Right-time eating."Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Moderate alcohol drinking means 0.3-0.5 g/kg alcohol daily, which will be not more than 2 glasses of wine depending on subject's weight. Alcohol will always be consumed in the evening with food or after food (e.g., dinner). The timing of alcohol consumption will be consistent for each individual. Subjects will be provided with red wine for the 1 alcohol intervention week. The order of conditions will be random.