Evolution of the Physical Condition in Treated Cancer Patients (PROTECT-01)

Adaptated Physical Activity (APA) during treatment of cancer is one of the actual global health recommendation because of the benefits observed in several parameters evaluated in many clinical studies. A best knowledge of the physical and medical characteristics of patients, including type of cancer and type of treatment, is primordial to optimize the patient care and the effectiveness of APA programs. Descriptive, explorative and prospective study of 3 different populations: One population with locally advanced or metastatic non-small cell lung cancer treated with multiple therapeutic lines. Two different populations of early cancer patients and treated with a platinum-based regimen for colon cancer and a taxane-based chemotherapy for breast cancer.

Evaluation of the physical condition and the quality of life during the course of treatment (after 8 weeks of treatment) and at the end of the treatment's line (except for breast cancer patients)

To describe exercise tolerance, by a six-minute walk test, in patients treated for a cancer (of lung, breast or colon) after 8 weeks of treatment.

To describe objective and felt fatigue by Fonctional assessment of chronic illness therapy-fatique (41 items scale)

To describe muscular strenght by FPmax: Maximal strenght of finger flexors; (measured in Newton with a dynamometer)

To describe muscular strenght by IFP: Fatigability indexof finger flexors; (measured in Newton with a dynamometer)

To describe muscular strenght by FIEmax: Maximal isometric strenght of knee extensors; (measured in Newton with a dynamometer)

To describe muscular strenght by IFE: Fatigability index of knee extensors; (measured in Newton with a dynamometer)

Spirometry measures lung function, specifically the amount (volume) of air that can be inhaled and exhaled

To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the gait speed

To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the chair stand

To describe physical performance index by Short Physical Performance Battery which is a group of measures that combines the results of the balance tests

Inclusion Criteria: Woman with breast cancer treated with adjuvant chemotherapy (taxane) or patient with colon cancer treated with adjuvant regimen (FOLFOX) or patient with locally advanced or metastatic lung cancer Patient without contraindication to the study-specific assessments Eastern Cooperative Oncology Group ≤ 2 Age ≥ 18 years old Life expectancy > 6 months Able to speak, read and understand French Written informed consent obtained from the patient Registration in a national health care system Exclusion Criteria: Patient with psychiatric, neurologic or musculoskeletal disorders Pregnant or breastfeeding women Minor or protected adult

Mallard J, Hucteau E, Schott R, Petit T, Demarchi M, Belletier C, Ben Abdelghani M, Carinato H, Chiappa P, Fischbach C, Kalish-Weindling M, Bousiniere A, Dufour S, Favret F, Pivot X, Hureau TJ, Pagano AF. Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol. Front Oncol. 2020 Aug 7;10:1304. doi: 10.3389/fonc.2020.01304. eCollection 2020.