Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production (KETO-GUT)

This is an interventional treatment trial for Renal Failure Read More

Inclusion Criteria:

• CKD stage 4-5 with estimated glomerular filtration rate < 30 ml/min/1,73m2
• No dialysis
• No history of kidney transplantation
• Non-diabetic (fasting glucose <1.26 g / L, or no insulin or oral antidiabetic therapy)
• BMI between 18 and 30 kg / m2
• Patient followed in the nephrology department of Professor FOUQUE at the Lyon Sud hospital
• For women of childbearing age, at least one method of contraception recognized as effective
• Patient who gave consent to open participation and signed the consent to participate in the study

Exclusion Criteria:

• Patient with progressive inflammatory, infectious, cardiovascular or neoplastic disease
• Patient refusing a dietary follow-up
• Patient having a planned transplant or dialysis project in the next 6 months.
• Patient having a colectomy, resection of the small intestine or cholecystectomy
• Patient who has received antibiotics, prebiotics, probiotics in the last 3 months.
• Patient treated with more than 2 g of calcium per day
• Patient using laxatives (more than 2 per day)
• Patient having:
• Uncontrolled metabolic acidosis (bicarbonatemia <18 mM)
• Hyperparathyroidism (PTH greater than 5 times the upper limit of normal)
• Hypercalcemia (Calcium> 2.55 mmol / L) or hypophosphoremia <0.70 mmol / L
• Anemia (hemoglobinemia <80g / L)
• Undernutrition criteria: albumin <38 g / L or prealbumin <0.3 g / L
• Known hypersensitivity to any of the substances or excipients of Ketosteril
• Subject in exclusion period of a previous study
• Patient not affiliated to social security
• Patient under guardianship or in the interests of justice
• Patient who is pregnant, breastfeeding or likely to become pregnant during the study