Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment
Periodontal Pocket
About this trial
This is an interventional treatment trial for Periodontal Pocket
Eligibility Criteria
Inclusion Criteria:
- Patients with chronic periodontitis with CAL ≥ 5 mm.
- No history of any systemic condition.
- Patient able to follow the required instructions.
- Willing to sign an informed consent form.
- Didn't receive any antibiotic therapy and periodontal therapy in the last 2-3 months.
Exclusion Criteria:
- Patients with systemic diseases that influence the condition (ex, hypertension, diabetes, kidney diseases and transplants).
- Patients who refuse to write an informed consent form.
- Smokers.
- Taking certain medications including antibiotics, antihypertensive, anticonvulsants, immunosuppressants, or any other drug that may affect the periodontal health status.
- Pregnant and lactating women.
Sites / Locations
- College of Dentistry/ University of Baghdad
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
Lycopene
Minocycline HCL
Distilled water
Prepared by solving lycopene powder in a solvent (ethanol: propylene glycol: water in the ratio of 50:30:20). The solution was then gelled by adding 8% hydroxypropyl cellulose (HPC). The concentration of the prepared gel equals to 2%. After scaling, root planing, and polishing (SRP), the gel delivered into periodontal pocket using insulin syringes, the therapeutic dose is about 2mg/0.1 ml.
Minocycline HCL Microspheres, 1mg minocycline powder per cartridge. A locally applied antibiotic that is placed directly into the infected periodontal pocket following SCR.
Used to irrigate periodontal pockets after SRP