Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis (CINEBIOPHTA)
Endophthalmitis
About this trial
This is an interventional treatment trial for Endophthalmitis focused on measuring intraocular concentrations of antibiotics
Eligibility Criteria
Inclusion Criteria:
- Male or female > 18 years old
- Francophone
Patients referred to emergencies by an ophthalmologist or doctor, or patients already hospitalized, with a unfavourable course 48 hours after introduction of broad spectrum probabilistic antibiotic therapy for the following situations:
- Cataract surgery
- Vitreoretinal surgery
- Intravitreal injection [anti-VEGF for the treatment of AMD, dexamethasone (Ozurdex®) for the treatment of cystoid macular edema]
- Physical signs presence of intraocular inflammation (Tyndall, hypopyon, cyclic membrane, hyalite)
- Presence of functional signs (Decreased Visual Acuity)
- Patients for whom a management re-evaluation is essential with obligation of new intraocular samples.
- Patient affiliated to social security or, failing that, to another health insurance system
Exclusion Criteria:
- Patient under guardianship or curators
- Patient deprived of liberty
- Participation refusal in the study
Sites / Locations
- Groupe Hospitalier Paris Saint Joseph
Arms of the Study
Arm 1
Experimental
intraocular antibiotic concentrations determination
In the event that the patient develops unfavourably, the ophthalmologist include the patient in the trial. The patient is reviewed at 48 hours after the introduction of probabilistic antibiotic therapy for clinical reassessment and the return of microbiological test results. Following this inclusion, the new samples will be taken when the patient passes through the operating room for the treatment of his pathology as part of the care. Ophthalmologists may have to adapt the patient's management (i.e. adjustment of antibiotic therapy) as part of their usual care routine. An anterior chamber puncture and a vitrectomy are performed. Eye fluids collected as part of the treatment are sent for analysis.