Ciprofloxacin Plus Metronidazole Vs Cefixime Plus Metronidazole Therapy for the Treatment of Liver Abscess (CMETRO)
Liver Abscess
About this trial
This is an interventional treatment trial for Liver Abscess
Eligibility Criteria
Inclusion Criteria:
- Irrespective of gender
- Age ≥ 18 years
- Symptomatic patients of liver abscess confirmed with radiology imaging, either by ultrasonography (USG) or computed tomographgy (CT) scan
Exclusion Criteria:
- Past history of liver abscess
- Chronic kidney disease (CKD)
- History of hypersensitivity to either Ciprofloxacin or Metronidazole or Cefixime
- Shock (blood pressure <90/60 mmHg) at presentation
- ARDS (PaO2/FiO2≤300)
- Encephalopathy (altered sensorium with GCS <15)
- Acute kidney injury (AKI, Increase in serum creatinine to ≥1.5 times from the baseline)
- Pregnancy at presentation
- Already received antibiotics for more than 48 hours prior to the admission
- Not able to take orally
- Receiving blood thinners like anti-platelets, anti-coagulation agents within 4 weeks of presentation
Sites / Locations
- Post Graduate Institute of Medical Education and Research
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Ciprofloxacin plus Metronidazole therapy
Cefixime plus Metronidazole Therapy
Will receive tablet Ciprofloxacin (500 mg BDS) and tablet Metronidazole (800 mg TDS) orally for 2 weeks. Percutaneous aspiration or drainage of the liver abscess will be done for all the participants when there is enough liquid content/pus which is amenable for aspiration or drainage. Percutaneous drainage or aspiration will be done in liver abscess with size of ≥ 5 cm and <5 cm respectively. After 2 weeks of empirical antibiotic therapy, asymptomatic patients with persistent drainage with USG showing significant drainable collection in the liver will receive another 2 weeks of extended antimicrobial therapy of same combination.
Will receive tablet Cefixime (200 mg BDS) and tablet Metronidazole (800 mg TDS) orally for 2 weeks.Percutaneous aspiration or drainage of the liver abscess will be done for all the participants when there is enough liquid content/pus which is amenable for aspiration or drainage. Percutaneous drainage or aspiration will be done in liver abscess with size of ≥ 5 cm and <5 cm respectively. After 2 weeks of empirical antibiotic therapy, asymptomatic patients with persistent drainage with USG showing significant drainable collection in the liver will receive another 2 weeks of extended antimicrobial therapy of same combination.