Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension (IOH)
Orthostatic Intolerance, Syncope, Fainting
About this trial
This is an interventional treatment trial for Orthostatic Intolerance focused on measuring Initial Orthostatic Hypotension, IOH, Physical Counter-maneuver, Refractory Period, Active Stand, Muscle Tensing, Leg Crossing, Lower Body Muscle Tensing
Eligibility Criteria
Inclusion Criteria:
- Either have initial orthostatic hypotension or are a healthy volunteer
- 18-50 years old
- Male or Female
- Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Research Testing Lab in the Teaching, Research & Wellness Building at the University of Calgary, Calgary, AB
- Able and willing to provide informed consent
Exclusion Criteria:
- Inability to stand up or perform leg exercises without assistance
- Sustained orthostatic hypotension past 3 minutes of standing
- Pregnant
Sites / Locations
- University of Calgary
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
No Intervention
Experimental
Experimental
Experimental
Experimental
Experimental
No Physical Intervention
Supine Knee Raises
Leg Crossing
Cold Pressor Test
Serial 7's Stress Test
Functional Electrical Stimulation
The participant will actively stand up from a seated position without performing any physical counter-maneuvers either prior to or following the stand.
The participant will perform 30 seconds of raising their knees to their chest while sitting down before actively standing.
The participant will actively stand and then immediately cross their legs and tense their leg muscles for 60 seconds.
The participant will submerge their hands in ice water for approximately 45 seconds.
The participant will perform a mental arithmetic stress test for 30 seconds prior to standing.
The participant will have their quadriceps passively contracted using mild electrical stimulation for approximately 30 seconds prior to standing.