Influence of Enamel Matrix Derivative (Emdogain®) on Palate Wound Healing.
Palatal Wound
About this trial
This is an interventional treatment trial for Palatal Wound focused on measuring Wound Healing, Enamel Matrix Derivative, Palatal
Eligibility Criteria
Inclusion Criteria:
- Patients with at least 18 years of age, systemically healthy, with good oral hygiene, assessed by plaque index and gingival index of less than 25% (O'Leary et al., 1972);
- Patients with no morphological or pathological changes in the donor palatine region;
- Patients who present an indication of exodontia and with ridge preservation indication for future implantation of implants;
- The tooth included in the study, as well as the adjacent teeth, do not present a loss of periodontal insertion;
- Patients who agreed to and signed the formal consent to participate in the study after receiving an explanation of risks and benefits from an individual who was not a member of the present study (Resolution no. 118 - May, 2012, and Ethics and Code of Professional Conduct in Dentistry - 118/12).
Exclusion Criteria:
- Patients with systemic problems (cardiovascular, blood dyscrasias, immunodeficiency, and diabetes, among others) that will contraindicate the surgical procedure;
- Patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;
- Smokers patients;
- Pregnant or lactating patients;
- Patients who had had periodontal surgery on the study area;
- Patients who present opportunistic oral lesions mainly colonized the palate region;
Sites / Locations
- Manuela Maria Viana MiguelRecruiting
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Experimental
Control Group - Free Gingival Graft
Test Group - Free Gingival Graft + EMD
With the aim to ridge preservation after condemned tooth extraction, the socket will be sealed with a free gingival graft removed from the palate. The tooth will be extracted through the use of appropriate instruments in order to obtain a minimally traumatic exodontia. After the exodontia, curettage and irrigation of the dental socket will be performed. The free gingival graft will be removed from the donor palatal area with a circular incision of 8 mm and 2 mm thickness. After free gingival graft removal from palate, it will be adjusted to the entrance of the socket and sutured. Patient randomized to the Control Group will not receive any kind of treatment in the palatal region.
With the aim to ridge preservation after condemned tooth extraction, the socket will be sealed with a free gingival graft removed from the palate. The tooth will be extracted through the use of appropriate instruments in order to obtain a minimally traumatic exodontia. After the exodontia, curettage and irrigation of the dental socket will be performed. The free gingival graft will be removed from the donor palatal area with a circular incision of 8 mm and 2 mm thickness. After free gingival graft removal from palate, it will be adjusted to the entrance of the socket and sutured. EMD will be applied immediately after the graft removal surgical procedure on the palatal donor area, leaving it in contact with the wound for 5 min. In sequence, it will be covered with an individualized acetate plate that will extend throughout the palatal area and be in position for 2 hours after the procedure