G-EO Gait Rehabilitation Training in Progressive Multiple Sclerosis
Progressive Multiple Sclerosis
About this trial
This is an interventional treatment trial for Progressive Multiple Sclerosis focused on measuring Robotics, Gait Training
Eligibility Criteria
Inclusion Criteria:
- 18-64 years
- Confirmed diagnosis of Primary or Secondary Progressive Multiple Sclerosis (this will be confirmed by the referring physician)
- EDSS 4.0-7.522
- Stable course of disease-modifying therapy over the past 6 months
- Asymptomatic (i.e., no underlying cardiovascular disease)
- Physician approval for exercise
- Willingness to visit the IU Health Neurosciences Center for testing and training
Exclusion Criteria:
- Pregnancy
- Current use of dalfampridine (Ampyra®)
- Conventional physical therapy or G-EO training within the past 6 months
- Height <1m or >2m
- Body weight >150 kg
- Contraindications to G-EO gait training (e.g., bone instability)
Sites / Locations
- Neurorehabilitation and Robotics at IU Health Neuroscience Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Conventional Physical Therapy
End-Effector Robotic Training
Conventional physical therapy (CPT): CPT sessions will involve a 3-5 minute warm-up, stretching, progressive strength training exercises, and gait and balance training.40-43 Additional strategies for home exercises, energy conservation, fall prevention, and appropriate assistive devices (i.e., orthotics) will be provided.
G-EO training: Using the G-EO System, participants will be secured with the appropriate sized harness and attached to an overhead body-weight support system, with feet secured to pressure sensitive footplates. Each session will begin with a 3-5 minute warm-up in the continuous passive mode (cadence ~40-45 steps/minute). The participant will then be transitioned into the adaptive training phase for practicing repetitive floor walking and stair climbing for up to 30 minutes. During this phase, the force produced by the robot is modulated to support the effort of the patient in producing a typical walking pattern.