Management of Moderately Hypoxemic Thoracic Trauma (TrOMaTho)
Chest Trauma, High Flow Oxygenation
About this trial
This is an interventional prevention trial for Chest Trauma
Eligibility Criteria
Inclusion Criteria:
- Major patient (age ≥ 18 years),
- Admitted to intensive care unit for less than 48 hours for the management of chest trauma.
- Closed chest trauma, non-penetrating, with a TTSS score> or equal to 4.
- Need for conventional oxygen therapy to maintain SpO2 greater than or equal to 95%.
- Patient affiliated or beneficiary of a social security scheme
- Patient having signed a consent
Exclusion Criteria:
- Severe hypoxemia defined as a PaO2/FiO2 ratio < 200 noted before randomization
- Recommended indication for NIV: cardiogenic pulmonary oedema, decompensated COPD.
Indication to immediate oro-tracheal intubation. (will not be excluded patients requiring general anaesthesia for a surgical procedure for a peripheral surgical procedure or embolization)
- Patient with acute respiratory distress, whatever the cause.
- Hemodynamic instability marked by a fall of the PAS> 30% or a PAS <110 mmHg despite the initial resuscitation measures
- Neurological degradation with Glasgow score less than 12
- Pregnant or lactating woman
- Patient under guardianship or curatorship
- Contraindication to the use of one or both devices studied (decaying facial trauma)
Sites / Locations
- Centre Hospitalier de CornouailleRecruiting
- Angers university hospitalRecruiting
- Brest university hospitalRecruiting
- Chartres HospitalRecruiting
- HIA PercyRecruiting
- Dreux hospitalRecruiting
- Le Mans hospitalRecruiting
- Centre Hospitalier de Bretagne SudRecruiting
- La Timone Hospital (AP-HM)
- Marseille university horpitalRecruiting
- CHRU de MontpellierRecruiting
- Morlaix hospitalRecruiting
- Nantes university hospitalRecruiting
- CHRU de la Pitié-SalpétrièreRecruiting
- Kremlin Bicêtre university hospital (APHP)Recruiting
- Rennes, university HospitalRecruiting
- Tours university hospitalRecruiting
- CHBA de VannesRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Interventional group
Control group
Interventional group: All patients included in this group will receive a continuous heated and humidified high-flow (30 to 60 l/min) oxygenation with a nasal cannula for 48 hours. Initially, flow rate will be started at 50 l/min with a FiO2 at 50%. According to the protocol, flow rate and FiO2 will be titrated on SpO2 and respiratory tolerance. Weaning and failure of high-flow oxygenation are described in detail in the study protocol.
Control group: All patients included in this group will receive a low flow oxygenation (flow rate < 15 l/min) with nasal cannula (flow rate ≤ 6 l/min) or non-rebreathing mask (flow rate ≥ 7 l/min).